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6 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Jungmin Choi; Daniel Zelterman;
    Publisher: Elsevier BV
    Project: NIH | A model for predicting re... (5R01CA208403-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of Response an... (1F32CA210516-01A1), NIH | COMPREHENSIVE CANCER CENT... (2P30CA016359-15), NIH | Mechanisms and Modulators... (5P01CA129243-07), NIH | Targeting the Immune Syst... (5R01CA195720-03), NIH | Yale SPORE in Lung Cancer... (3P50CA196530-02S1)

    Abstract Background Although EGFR mutant tumors exhibit low response rates to immune checkpoint blockade overall, some EGFR mutant tumors do respond to these therapies; however, there is a lack of understanding of the characteristics of EGFR mutant lung tumors responsiv...

  • publication . Article . Other literature type . 2013
    Open Access
    Authors:
    Lockwood, William W.; Chandel, Sahiba K.; Stewart, Greg L.; Erdjument-Bromage, Hediye; Beverly, Levi J.;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Mechanisms of Metastasis ... (5P01CA094060-07), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Molecular Targets COBRE (8P20GM103482-10), NIH | Mechanisms and Modulators... (5P01CA129243-07)

    Identification of novel proteins that can potentially contribute to carcinogenesis is a requisite venture. Herein, we report the first biochemical characterization of the novel F-box and WD40 containing protein, FBXW4. We have identified interacting protein partners and...

  • publication . Article . 2016
    Open Access English
    Authors:
    Chen, Qing; Boire, Adrienne; Jin, Xin; Valiente, Manuel; Er, Ekrem Emrah; Lopez-Soto, Alejandro; Jacob, Leni; Patwa, Ruzeen; Shah, Hardik; Xu, Ke; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Role of the Perivascular ... (5U54CA163167-04), NIH | Mechanisms and Modulators... (5P01CA129243-07)

    SUMMARY Brain metastasis represents a substantial source of morbidity and mortality in various cancers, and is characterized by high resistance to chemotherapy. Here we define the role of the most abundant cell type in the brain, the astrocyte, in promoting brain metast...

  • publication . Article . 2019
    Open Access
    Authors:
    Suzawa, Ken; Offin, Michael; Schoenfeld, Adam J.; Plodkowski, Andrew J.; Odintsov, Igor; Lu, Daniel; Lockwood, William W.; Arcila, Maria E.; Rudin, Charles M.; Drilon, Alexander; ...
    Publisher: American Society of Clinical Oncology (ASCO)
    Project: NIH | Mechanisms and Modulators... (5P01CA129243-07), NIH | Cancer Chemotherapy Train... (5T32CA009207-29), NIH | MOUSE GENETICS (2P30CA008748-43)
  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Shen, Ronglai; Seshan, Venkatraman E.;
    Publisher: Oxford University Press (OUP)
    Project: NIH | Statistical Strategies fo... (5R01CA163251-03), NIH | Defining a novel subtype ... (1R21CA195365-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms and Modulators... (5P01CA129243-07)

    Allele-specific copy number analysis (ASCN) from next generation sequencing (NGS) data can greatly extend the utility of NGS beyond the identification of mutations to precisely annotate the genome for the detection of homozygous/heterozygous deletions, copy-neutral loss...

  • publication . Preprint . Other literature type . Article . 2019
    Open Access English
    Authors:
    Christopher H. Hulton; Emily A. Costa; Nisargbhai S. Shah; Alvaro Quintanal-Villalonga; Glenn Heller; Elisa de Stanchina; Charles M. Rudin; John T. Poirier;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Coordinating center for t... (5U24CA213274-02), NIH | Mechanisms and Modulators... (5P01CA129243-07), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | CORE GRANT FOR VISION RES... (5P30EY012196-20), NIH | Identification and valida... (5U01CA199215-02)

    Patient-derived xenografts (PDXs) are high-fidelity in vivo tumor models that accurately reflect many key aspects of human cancer. In contrast to cancer cell lines or genetically engineered mouse models, the utility of PDXs has been limited by the inability to perform t...

6 research outcomes, page 1 of 1
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