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5 research outcomes, page 1 of 1
  • publication . Article . 2016
    Open Access English
    Authors:
    Hespe, Geoffrey E.; Kataru, Raghu P.; Savetsky, Ira L.; García Nores, Gabriela D.; Torrisi, Jeremy S.; Nitti, Matthew D.; Gardenier, Jason C.; Zhou, Jie; Yu, Jessie Z.; Jones, Lee W.; ...
    Publisher: John Wiley and Sons Inc.
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of fibrosis an... (4R01HL111130-05)

    Key points Obesity results in perilymphatic inflammation and lymphatic dysfunction.Lymphatic dysfunction in obesity is characterized by decreased lymphatic vessel density, decreased collecting lymphatic vessel pumping frequency, decreased lymphatic trafficking of immune...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    García Nores, G D; Cuzzone, D A; Albano, N J; Hespe, G E; Kataru, R P; Torrisi, J S; Gardenier, J C; Savetsky, I L; Aschen, S Z; Nitti, M D; ...
    Publisher: Springer Nature
    Project: NIH | SURGICAL ONCOLOGY RESEARC... (5T32CA009501-22), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of fibrosis an... (4R01HL111130-05)

    Background/Objectives: High-fat diet (HFD)-induced obesity has significant negative effects on lymphatic function, but it remains unclear whether this is a direct effect of HFD or secondary to adipose tissue deposition. Methods: We compared the effects of HFD on obesity...

  • publication . Other literature type . Article . 2015
    Open Access
    Authors:
    Geoffrey Hespe; Ira Savetsky; Daniel Cuzzone; Raghu Kataru;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of fibrosis an... (4R01HL111130-05)

    Obesity is a major risk factor for inflammatory dermatologic diseases, including atopic dermatitis and psoriasis. In addition, recent studies have shown that obesity impairs lymphatic function. As the lymphatic system is a critical regulator of inflammatory reactions, w...

  • publication . Article . Other literature type . 2020
    Open Access
    Authors:
    Wiser, Itay; Mehrara, Babak J.; Coriddi, Michelle; Kenworthy, Elizabeth; Cavalli, Michele; Encarnacion, Elizabeth; Dayan, Joseph H.;
    Publisher: MDPI AG
    Project: NIH | Restoration of lymphatic ... (5R21CA194882-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of fibrosis an... (4R01HL111130-05)

    0.001). L-Dex scores were highly sensitive and had a high positive predictive value for diagnosing lymphedema in patients with a volume excess of 10% or more. ICG was highly sensitive in identifying lymphedema. Lymphoscintigraphy had an overall low sensitivity and speci...

  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Jung-Ju Huang; Jason C. Gardenier; Geoffrey E. Hespe; Gabriela D. García Nores; Raghu P. Kataru; Catherine L. Ly; Inés Martínez-Corral; Sagrario Ortega; Babak J. Mehrara;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Restoration of lymphatic ... (5R21CA194882-02), NIH | Mechanisms of fibrosis an... (4R01HL111130-05), NIH | SURGICAL ONCOLOGY RESEARC... (5T32CA009501-22)

    Introduction Secondary lymphedema is a common complication of cancer treatment and recent studies have demonstrated that lymph node transplantation (LNT) can decrease swelling, as well as the incidence of infections. However, although these results are exciting, the mec...

5 research outcomes, page 1 of 1
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