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7 research outcomes, page 1 of 1
  • publication . Preprint . Other literature type . 2017
    Open Access
    Authors:
    Azizi, Elham; Carr, Ambrose J.; Plitas, George; Cornish, Andrew E.; Konopacki, Catherine; Prabhakaran, Sandhya; Nainys, Juozas; Wu, Kenmin; Kiseliovas, Vaidotas; Setty, Manu; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Integrative Cancer Genomi... (5R01CA164729-03), NIH | Self Peptides Bound to MH... (5R37AI034206-18), NIH | Single cell mapping of de... (7DP1HD084071-04)

    <jats:title>SUMMARY</jats:title><jats:p>Knowledge of immune cell phenotypes in the tumor microenvironment is essential for understanding mechanisms of cancer progression and immunotherapy response. We created an immune map of breast cancer using single-cell RNA-seq data...

  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Levine, Andrew G.; Hemmers, Saskia; Baptista, Antonio P.; Schizas, Michail; Faire, Mehlika B.; Moltedo, Bruno; Konopacki, Catherine; Schmidt-Supprian, Marc; Germain, Ronald N.; Treuting, Piper M.; ...
    Publisher: Rockefeller University Press
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MOLECULAR ANALYSIS OF THE... (1F32GM013039-01), NIH | Self Peptides Bound to MH... (5R37AI034206-18)

    Levine et al. investigate the extent to which regulatory T cells with either a monoclonal T cell receptor (TCR) or random TCR repertoire in place of their developmentally selected specificities maintain TCR-dependent gene expression and immunosuppressive function.

  • publication . Article . 2019
    Open Access English
    Authors:
    Amy Sun; Sergei B. Koralov;
    Publisher: Elsevier
    Project: NIH | Regulation of Nfil3 in in... (1R01AI130043-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Self Peptides Bound to MH... (5R37AI034206-18), NIH | ELUCIDATION OF IMMUNOGLOB... (5R01AI072194-04), NIH | The natural killer cell r... (1R01AI100874-01), NIH | Delineating The Differenc... (1R21AI137752-01A1), NIH | RNA-directed targeting of... (5R01AI124186-02)

    In Brief Yen et al. demonstrate that CHD4, a component of the NuRD remodeling complex, is essential for early B cell development, represses p53 expression in mature B cells, and influences the recruitment of AID to DNA during class switch recombination.

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Xiying Fan; Bruno Moltedo; Alejandra Mendoza; Alexey N. Davydov; Mehlika B. Faire; Linas Mazutis; Roshan Sharma; Dana Pe’er; Dmitriy M. Chudakov; Alexander Y. Rudensky;
    Publisher: Rockefeller University Press
    Project: NIH | Self Peptides Bound to MH... (5R37AI034206-18), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Function of Regulatory T ... (5F30AI122721-02)

    Fan et al. have identified a population of recirculating Treg cells with greater suppressive ability and a unique tissue distribution. Using single-cell RNA-seq, they place these Treg cells at the apex of the Treg developmental trajectory and show that similar cells may...

  • publication . Article . 2016
    Open Access English
    Authors:
    Chinen, Takatoshi; Kannan, Arun K.; Levine, Andrew G; Fan, Xiying; Klein, Ulf; Zheng, Ye; Gasteiger, Georg; Feng, Yongqiang; Fontenot, Jason D.; Rudensky, Alexander Y.;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | Self Peptides Bound to MH... (5R37AI034206-18)

    Regulatory T (Treg) cells, expressing abundant amounts of the IL-2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells. This feature implied a key role for a simple network based on IL-2 consumption by Treg cells in their suppressor function. However, co...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Stanislav Dikiy; Rachel Niec;
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Self Peptides Bound to MH... (5R37AI034206-18)

    Adaptive immune responses are tailored to different types of pathogens through differentiation of naive CD4 T cells into functionally distinct subsets of effector T cells (T helper 1 (TH1), TH2, and TH17) defined by expression of the key transcription factors T-bet, GAT...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Green, Jesse A.; Arpaia, Nicholas; Schizas, Michail; Dobrin, Anton; Rudensky, Alexander Y.;
    Publisher: The Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Self Peptides Bound to MH... (5R37AI034206-18)

    The involvement of effector T cells and regulatory T (T reg) cells in opposing and promoting solid organ carcinogenesis, respectively, is viewed as a shifting balance between a breach versus establishment of tolerance to tumor or self-antigens. We considered that tumor-...

7 research outcomes, page 1 of 1
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