Filters (3 )
Download Results
12 research outcomes, page 1 of 2
  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Darren R. Veach; Joseph Osborne; Daniel E. Spratt;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Immuno-PET With Anti-PSMA... (1R21CA153177-01A1), NIH | Molecular Imaging: Traini... (1R25CA096945-01), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10), NIH | Image Analysis and Biosta... (5P50CA086438-08), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    Background We applied a non-linear immunokinetic model to quantitatively compare absolute antibody uptake and turnover in subcutaneous LNCaP human prostate cancer (PCa) xenografts of two radiolabeled forms of the humanized anti-prostate-specific membrane antigen (PSMA) ...

  • publication . Other literature type . Article . 2011
    Open Access
    Authors:
    Tianhua Guo; Charlotte Ariyan; James P. Allison;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Administrative Core (5P50CA140146-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | PI 3-KINASE AND KIT RECEP... (5R01HL055748-03), NIH | A Mouse Model for Human G... (5R01CA102774-04), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1), NIH | Molecular Mechanisms in G... (7R01CA102613-12)

    Imatinib mesylate targets mutated KIT oncoproteins in gastrointestinal stromal tumor (GIST) and produces a clinical response in 80% of patients. The mechanism is believed to depend predominantly on the inhibition of KIT-driven signals for tumor-cell survival and prolife...

  • publication . Article . Other literature type . 2013
    Open Access
    Authors:
    Joseph A O'Donoghue; Sean Carlin;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Tumor Hypoxia Imaging - L... (1P01CA115675-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    Background: Hypoxia within solid tumors confers radiation resistance and a poorer prognosis. 124I-iodoazomycin galactopyranoside (124I-IAZGP) has shown promise as a hypoxia radiotracer in animal models. We performed a clinical study to evaluate the safety, biodistributi...

  • publication . Article . 2012
    Open Access
    Authors:
    Jason Lewis; Jason P. Holland; Samuel Rice;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Molecular Imaging: Traini... (1R25CA096945-01), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    A non-invasive technology that quantitatively measures the activity of oncogenic signaling pathways could broadly impact cancer diagnosis and treatment using targeted therapies. Here we describe the development of 89Zr-desferrioxamine transferrin (89Zr-Tf), a novel posi...

  • publication . Article . 2009
    Open Access
    Authors:
    Du, Yi-Chieh Nancy; Klimstra, David S.; Varmus, Harold;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Mechanisms of Metastasis ... (5P01CA094060-07), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Tumor maintenance and dev... (1U01CA105492-01), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    It is unclear whether the cellular origin of various forms of pancreatic cancer involves transformation or transdifferentiation of different target cells or whether tumors arise from common precursors, with tumor types determined by the specific genetic alterations. Pre...

  • publication . Article . Other literature type . 2016
    Open Access Russian
    Authors:
    Ke Xu; Elliott Brea;
    Project: NIH | The Roles of Microglia an... (1F31CA167863-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Novel Nano-Constructs to ... (1R21CA128406-01), NIH | Improving therapy of glio... (5R01CA166078-04), NIH | MONOCLONAL ANTIBODY THERA... (5P01CA033049-13), NIH | Biology of Alpha Particle... (2R01CA055349-16A2), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    Single-wall carbon nanotubes present unique opportunities for drug delivery, but have not advanced into the clinic. Differential nanotube accretion and clearance from critical organs have been observed, but the mechanism not fully elucidated. The liver has a complex cel...

  • publication . Article . Other literature type . 2010
    Open Access
    Authors:
    Marta Barreto; Nagahide Takahashi; nicolas ramoz; Joseph D Buxbaum;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    Background SLC25A12 , a susceptibility gene for autism spectrum disorders that is mutated in a neurodevelopmental syndrome, encodes a mitochondrial aspartate-glutamate carrier (aspartate-glutamate carrier isoform 1 [AGC1]). AGC1 is an important component of the malate/a...

  • publication . Article . 2020
    Open Access
    Authors:
    Vivier, Delphine; Fung, Kimberly; Rodriguez, Cindy; Adumeau, Pierre; Ulaner, Gary A.; Lewis, Jason S.; Sharma, Sai Kiran; Zeglis, Brian M.;
    Publisher: Ivyspring International Publisher
    Project: NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1), NIH | Pretargeted Clinical Imag... (1U01CA221046-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | The Clinical PET Imaging ... (5R01CA204167-02)

    Rationale: The overwhelming majority of radioimmunoconjugates are produced via random conjugation methods predicated on attaching bifunctional chelators to the lysines of antibodies. However, this approach inevitably produces poorly defined and heterogeneous immunoconju...

  • publication . Other literature type . Article . 2013
    Open Access
    Authors:
    Thorek, Daniel LJ; Ogirala, Anuja; Beattie, Bradley J; Grimm, Jan;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Cerenkov-emission based n... (5R01EB014944-04), NIH | Molecular Imaging: Traini... (5R25CA096945-07), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    In the era of personalized medicine there is an urgent need for in vivo techniques able to sensitively detect and quantify molecular activities. Sensitive imaging of gamma rays is widely used, but radioactive decay is a physical constant and signal is independent of bio...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Adumeau P; Ke, Carnazza; Christian Brand; Sd, Carlin; Reiner T; Bj, Agnew; Js, Lewis; Bm, Zeglis;
    Publisher: Ivyspring International Publisher
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Pretargeted Radioimmunoth... (4R00CA178205-02), NIH | Basic and Translational R... (5G12MD007599-29), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    The complementary nature of positron emission tomography (PET) and near-infrared fluorescence (NIRF) imaging makes the development of strategies for the multimodal PET/NIRF imaging of cancer a very enticing prospect. Indeed, in the context of colorectal cancer, a single...

12 research outcomes, page 1 of 2
Last index information