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9 research outcomes, page 1 of 1
  • publication . Preprint . 2018
    Open Access
    Authors:
    Ibrahim El-Hamamy;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Mouse models to discover ... (5R01CA159859-07), NIH | Engrailed genes and cereb... (5R37MH085726-09), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Developmental studies to ... (5R01CA192176-02), NIH | Signaling pathways that r... (1R01NS092096-01), NIH | Medulloblastoma and Metas... (5R01CA148699-02), CIHR

    <jats:title>Summary</jats:title><jats:p>The study of the origin and development of cerebellar tumours has been hampered by the complexity and heterogeneity of cerebellar cells that change over the course of development. We used single-cell transcriptomics to study &gt;6...

  • publication . Article . 2017
    Open Access English
    Authors:
    Wojcinski, Alexandre; Lawton, Andrew K.; Bayin, N Sumru.; Lao, Zhimin; Stephen, Daniel N.; Joyner, Alexandra L.;
    Project: NIH | Role of granule neuron pr... (5F32NS086163-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Signaling pathways that r... (1R01NS092096-01)

    Regeneration of several organs involves adaptive reprogramming of progenitors, however, the intrinsic capacity of the developing brain to replenish lost cells remains largely unknown. In this study, we discovered that the developing cerebellum has unappreciated progenit...

  • publication . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Yang, Zhaohui; Joyner, Alexandra L.;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Signaling pathways that r... (1R01NS092096-01)

    <jats:title>ABSTRACT</jats:title><jats:p>The cerebellum (CB) undergoes major rapid growth during the third trimester and early neonatal stage in humans, making it vulnerable to injuries in pre-term babies. Experiments in mice have revealed a remarkable ability of the ne...

  • publication . Preprint . Article . 2018
    Open Access English
    Authors:
    Engstrom, T. A.; Zhang, Teng; Lawton, A. K.; Joyner, A. L.; Schwarz, J. M.;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Signaling pathways that r... (1R01NS092096-01), NIH | Role of granule neuron pr... (5F32NS086163-02), NIH | Engrailed genes and cereb... (5R37MH085726-09)

    Comment: version accepted by Physical Review X

  • publication . Preprint . Other literature type . Article . 2018
    Open Access English
    Authors:
    Andrew K Lawton; Tyler Engstrom; Daniel Rohrbach; Masaaki Omura; Daniel H Turnbull; Jonathan Mamou; Teng Zhang; J M Schwarz; Alexandra L Joyner;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Ultrasound Scattering Mod... (1R21EB016117-01), NIH | Signaling pathways that r... (1R01NS092096-01), NIH | Engrailed genes and cereb... (5R37MH085726-09), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Role of granule neuron pr... (5F32NS086163-02), NSF | Near the onset of rigidit... (1507938)

    [u'The human brain has a characteristic pattern of ridges and grooves that make up its folded shape. Folds in the outer layer of the brain, known as the cortex, increase the surface area and make more space for cells to connect and form complex circuitries. Different mo...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Willett, Ryan T; Bayin, N Sumru; Lee, Andrew S; Krishnamurthy, Anjana; Wojcinski, Alexandre; Lao, Zhimin; Stephen, Daniel; Rosello-Diez, Alberto; Dauber-Decker, Katherine L; Orvis, Grant D; ...
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | Engrailed genes and cereb... (5R37MH085726-09), NIH | Signaling pathways that r... (1R01NS092096-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Roles of engrailed protei... (5F32NS080422-03)

    <jats:p>For neural systems to function effectively, the numbers of each cell type must be proportioned properly during development. We found that conditional knockout of the mouse homeobox genes En1 and En2 in the excitatory cerebellar nuclei neurons (eCN) leads to redu...

  • publication . Article . Preprint . Other literature type . 2018
    Open Access
    Authors:
    Bayin, N Sumru; Wojcinski, Alexandre; Mourton, Aurelien; Saito, Hiromitsu; Suzuki, Noboru; Joyner, Alexandra L;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | Signaling pathways that r... (1R01NS092096-01), NIH | Engrailed genes and cereb... (5R37MH085726-09), NIH | MOUSE GENETICS (2P30CA008748-43)

    Outside of the neurogenic niches of the brain, postmitotic neurons have not been found to undergo efficient regeneration. We demonstrate that mouse Purkinje cells (PCs), which are born at midgestation and are crucial for development and function of cerebellar circuits, ...

  • publication . Preprint . Other literature type . Article . 2019
    Open Access
    Authors:
    Elham Ahmadzadeh; N. Sumru Bayin; Xinli Qu; Aditi Singh; Linda Madisen; Daniel Stephen; Hongkui Zeng; Alexandra L. Joyner; Alberto Rosello-Diez;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Signaling pathways that r... (1R01NS092096-01), NIH | A novel genetic approach ... (5R21HD083860-02)

    <jats:title>Abstract</jats:title><jats:p>Thanks to many advances in genetic manipulation, mouse models have become very powerful in their ability to interrogate biological processes. In order to precisely target expression of a gene of interest to particular cell types,...

  • publication . Preprint . Article . Other literature type . 2018
    Open Access English
    Authors:
    Wojcinski, Alexandre; Morabito, Morgane; Lawton, Andrew K.; Stephen, Daniel N.; Joyner, Alexandra L.;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Role of granule neuron pr... (5F32NS086163-02), NIH | Signaling pathways that r... (1R01NS092096-01), NIH | Engrailed genes and cereb... (5R37MH085726-09)

    <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The cerebellum is a foliated posterior brain structure involved in coordination of motor movements and cognition. The cerebellum undergoes rapid growth postnataly due to Sonic Hedgehog...

9 research outcomes, page 1 of 1
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