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5 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Peter Tonge; Joe Matarlo;
    Publisher: American Chemical Society (ACS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Predoctoral Training in P... (1T32GM073546-01A1), NIH | Mechanism of Slow Onset E... (5R01GM102864-04), NIH | Rational Design of Adenyl... (5R01GM100477-08)

    A stereoselective synthesis has been developed to provide all four side-chain stereoisomers of difluoroindanediol 2, the mixture of which was previously identified as an inhibitor of the o-succinylbenzoate-CoA synthetase MenE in bacterial menaquinone biosynthesis, havin...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Christopher E. Evans; Yuanyuan Si; Joe S. Matarlo; Yue Yin; Jarrod B. French; Peter J. Tonge; Derek S. Tan;
    Publisher: American Chemical Society (ACS)
    Project: NIH | Mechanism of Slow Onset E... (5R01GM102864-04), NIH | Predoctoral Training in P... (1T32GM073546-01A1), NIH | Mechanisms that govern as... (1R35GM124898-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Rational Design of Adenyl... (5R01GM100477-08), NIH | Enhancement of user acces... (Y1GM0080-13-0-1)

    Graphical Abstract

  • publication . Preprint . 2020
    Open Access
    Authors:
    Forbes, Lauren; Cifani, Paolo; Minuesa, Gerard; Chen, Celine; Takao, Sumiko; Kharas, Michael G; Koche, Richard P.; Kentsis, Alex;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aberrant signaling in acu... (5R01CA204396-03), NIH | Predoctoral Training in P... (1T32GM073546-01A1)

    <jats:sec><jats:title>Highlights</jats:title><jats:list list-type="bullet"><jats:list-item><jats:p>Cell-penetrant peptidomimetic inhibitor selectively blocks oncogenic MYB:CBP/P300 activity in diverse leukemias but not normal blood cells</jats:p></jats:list-item><jats:l...

  • publication . Preprint . Article . 2017
    Open Access English
    Authors:
    Kavitha Ramaswamy; Lauren Forbes; Gerard Minuesa; Tatyana Gindin; Fiona Brown; Michael G. Kharas; Andrei V. Krivtsov; Scott A. Armstrong; Eric Still; Elisa de Stanchina; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Characterizing MSI2 in le... (5R01CA193842-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Phosphoproteomic signatur... (5R21CA188881-02), NIH | Aberrant signaling in acu... (5R01CA204396-03), NIH | Uncovering the role for M... (5R01DK101989-03), NIH | Epigenetic mechanisms of ... (1K08CA191091-01A1), NIH | Predoctoral Training in P... (1T32GM073546-01A1)

    Aberrant gene expression is a hallmark of acute leukemias. MYB-driven transcriptional coactivation with CREB-binding protein (CBP)/P300 is required for acute lymphoblastic and myeloid leukemias, including refractory MLL-rearranged leukemias. Using structure-guided molec...

  • publication . Other literature type . Preprint . Article . 2018
    Open Access
    Authors:
    Paul Greengard; George Liao; Peng Xu;
    Publisher: Proceedings of the National Academy of Sciences
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Predoctoral Training in P... (1T32GM073546-01A1), NIH | MECHANISMS FOR SELECTIVE ... (1R01AG047781-01), NIH | Substrate Feedback Mechan... (1RF1AG057593-01), NIH | Mechanism and Synergy of ... (5R01NS096275-03)

    Significance γ-Secretase cleaves multiple transmembrane proteins, but little is known about how it controls its substrate specificity. γ-Secretase activating protein (GSAP) has been reported to differentially activate γ-secretase for APP and Notch cleavages. The mechani...

5 research outcomes, page 1 of 1
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