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8 research outcomes, page 1 of 1
  • publication . Article . 2009
    Open Access
    Authors:
    Du, Yi-Chieh Nancy; Klimstra, David S.; Varmus, Harold;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Mechanisms of Metastasis ... (5P01CA094060-07), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Tumor maintenance and dev... (1U01CA105492-01), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    It is unclear whether the cellular origin of various forms of pancreatic cancer involves transformation or transdifferentiation of different target cells or whether tumors arise from common precursors, with tumor types determined by the specific genetic alterations. Pre...

  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Masanori Okaniwa; ZHAN YAO;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of Metastasis ... (5P01CA094060-07), NIH | Orexin/Hypocretin Recepto... (7P50AA017072-07)

    Inhibitors of the mTOR kinase are in clinical trials for the treatment of cancer; here, mutations in mTOR that can lead to drug resistance are investigated and the results are used to design a new class of mTOR inhibitors that can overcome this resistance. Inhibitors of...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Harihar Basnet; Lin Tian; Karuna Ganesh; Yun-Han Huang; Danilo G Macalinao; Edi Brogi; Lydia WS Finley; Joan Massagué;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Investigating L1CAM-depen... (1K08CA230213-01), NIH | Mechanisms of Metastasis ... (5P01CA094060-07), NIH | Mechanisms of Escape from... (5F30CA203238-03), NIH | Cancer Chemotherapy Train... (5T32CA009207-29)

    Metastasis-initiating cells dynamically adapt to the distinct microenvironments of different organs, but these early adaptations are poorly understood due to the limited sensitivity of in situ transcriptomics. We developed fluorouracil-labeled RNA sequencing (Flura-seq)...

  • publication . Article . 2016
    Open Access English
    Authors:
    Elizabeth M. Kass; Pei Xin Lim; Hildur R. Helgadottir; Mary Ellen Moynahan; Maria Jasin;
    Publisher: Nature Publishing Group
    Project: NIH | Mechanisms of Metastasis ... (5P01CA094060-07), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Double-Strand Break Repai... (5K99CA184122-02), NIH | HOMOLOGY-DIRECTED DNA REP... (5R01CA185660-04)

    Mutations in homology-directed repair genes like BRCA2 are linked to breast cancer susceptibility. Here the authors generate mice with an inducible DNA break-reporter system and see high levels of homology-directed repair in proliferative mammary tissue and a general re...

  • publication . Article . Other literature type . 2013
    Open Access
    Authors:
    Lockwood, William W.; Chandel, Sahiba K.; Stewart, Greg L.; Erdjument-Bromage, Hediye; Beverly, Levi J.;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Mechanisms of Metastasis ... (5P01CA094060-07), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Molecular Targets COBRE (8P20GM103482-10), NIH | Mechanisms and Modulators... (5P01CA129243-07)

    Identification of novel proteins that can potentially contribute to carcinogenesis is a requisite venture. Herein, we report the first biochemical characterization of the novel F-box and WD40 containing protein, FBXW4. We have identified interacting protein partners and...

  • publication . Preprint . 2020
    Open Access English
    Authors:
    Maria Tello-Lafoz; Katja Srpan; Jing Hu; Yevgeniy Romin; Annalisa Calò; Katharine C. Hsu; Joan Massagué; Morgan Huse; Ekrem Emrah Er;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Mechanisms of Metastasis ... (5P01CA094060-07), NIH | Synaptic Control of Cytot... (5R01AI087644-08), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | KIR and HLA in cis and tr... (5R01AI125651-03), NIH | Clinical and Translationa... (5UL1TR002003-02)

    <jats:title>ABSTRACT</jats:title><jats:p>Immune cells identify cancer cells by recognizing characteristic biochemical features indicative of oncogenic transformation. Cancer cells have characteristic mechanical features, as well, but whether these biophysical properties...

  • publication . Article . 2019
    Open Access English
    Authors:
    SANG BAE LEE; Bina Desai;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of Metastasis ... (5P01CA094060-07), NIH | Studies in Mice to Improv... (1R43CA150448-01), NIH | The Ureb-1 ubiquitin liga... (5R01CA131126-05), NIH | The role of Id proteins i... (5R01CA101644-09)

    Graphical Abstract

  • publication . Preprint . 2019
    Open Access
    Authors:
    Ganesh, Karuna; Wu, Chao; O’Rourke, Kevin P.; Adileh, Mohammad; Szeglin, Bryan C.; Wasserman, Isaac; Marco, Michael R.; Shady, Maha; Zheng, Youyun; Karthaus, Wouter R.; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Defining the Role of ERG ... (5R01CA193837-02), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of Metastasis ... (5P01CA094060-07), NIH | Modeling metastatic color... (5F30CA200110-02), NIH | Understanding Resistance ... (4R01CA155169-05), NIH | Investigating L1CAM-depen... (1K08CA230213-01), NIH | Cancer Chemotherapy Train... (5T32CA009207-29), NIH | Translational Research in... (5T32CA160001-03), NIH | CANCER EDUCATION PROGRAM (2R25CA020449-14),...

    <jats:title>Abstract</jats:title><jats:p>Rectal cancer (RC) is a challenging disease to treat that requires chemotherapy, radiation, and surgery to optimize outcomes for individual patients. No accurate model of RC exists to answer fundamental research questions relevan...

8 research outcomes, page 1 of 1
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