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13 research outcomes, page 1 of 2
  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Yaohua Xue; Luciano Martelotto; Timour Baslan; Alberto Vides; Martha Solomon; Trang Thi Mai; Neelam Chaudhary; Greg J Riely; Bob T Li; Kerry Scott; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Elucidating the regulatio... (5K08CA191082-02)

    The principles governing evolution of tumors exposed to targeted therapy are poorly understood. Here we modeled the selection and propagation of BRAF amplification (BRAFamp) in patient-derived tumor xenografts (PDX) treated with a direct ERK inhibitor, alone or in combi...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Elias Rodriguez-Fos; Anton Henssen; David Torrents; Ian C MacArthur; Richard Koche; Stephen Philip Jackson; Santiago Gonzalez Rosado;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | Clinical and Translationa... (3UL1TR000457-08S1), WT , NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Administrative Core (5P50CA140146-04)

    Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, including lethal rhabdoid tumors. Using assembly...

  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Andres Lopez-Albaitero; Hong Xu; Hongfen Guo; Linlin Wang; Zhihao Wu; Hoa Tran; Sarat Chandarlapaty; Maurizio Scaltriti; Yelena Janjigian; Elisa de Stanchina; ...
    Publisher: Informa UK Limited
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Head and Neck Training Pr... (5T32CA009685-23), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04)

    ABSTRACT T-cell-based therapies have emerged as one of the most clinically effective ways to target solid and non-solid tumors. HER2 is responsible for the oncogenesis and treatment resistance of several human solid tumors. As a member of the HER family of tyrosine kina...

  • publication . Other literature type . Preprint . 2019
    Open Access
    Authors:
    Kim, Jun Hyun; Penson, Alexander; Taylor, Barry S.; Petrini, John H.J.;
    Publisher: bioRxiv
    Project: NIH | Targeting AKT-Mutant Huma... (1R01CA207244-01), NIH | Understanding Long Tail D... (5R01CA204749-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04)

    <jats:title>Abstract</jats:title><jats:p>We derived a mouse model in which a mutant form of Nbs1 (Nbs1<jats:sup>mid8</jats:sup>) exhibits severely impaired binding to the Mre11-Rad50 core of the Mre11 complex. The<jats:italic>Nbs1</jats:italic><jats:sup><jats:italic>mid...

  • publication . Article . 2017
    Open Access
    Authors:
    Elliott Brea; Patrizia Mondello;
    Publisher: American Society of Hematology
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04)

    <jats:title>Abstract</jats:title> <jats:p>Oncogenic co-operation between c-Myc and activated phosphoinositide 3-kinase (PI3K) signaling pathways is crucial in lymphomagenesis, providing an opportunity for developing mechanism-based therapy to disrupt this co-operative s...

  • publication . Preprint . 2019
    Open Access
    Authors:
    Ganesh, Karuna; Wu, Chao; O’Rourke, Kevin P.; Adileh, Mohammad; Szeglin, Bryan C.; Wasserman, Isaac; Marco, Michael R.; Shady, Maha; Zheng, Youyun; Karthaus, Wouter R.; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Defining the Role of ERG ... (5R01CA193837-02), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of Metastasis ... (5P01CA094060-07), NIH | Modeling metastatic color... (5F30CA200110-02), NIH | Understanding Resistance ... (4R01CA155169-05), NIH | Investigating L1CAM-depen... (1K08CA230213-01), NIH | Cancer Chemotherapy Train... (5T32CA009207-29), NIH | Translational Research in... (5T32CA160001-03), NIH | CANCER EDUCATION PROGRAM (2R25CA020449-14),...

    <jats:title>Abstract</jats:title><jats:p>Rectal cancer (RC) is a challenging disease to treat that requires chemotherapy, radiation, and surgery to optimize outcomes for individual patients. No accurate model of RC exists to answer fundamental research questions relevan...

  • publication . Other literature type . Article . 2017 . Embargo End Date: 01 Jun 2017
    Open Access
    Authors:
    Kevin P O'Rourke; Evangelia Loizou; Geulah Livshits; Emma M Schatoff; Timour Baslan; Eusebio Manchado; Janelle Simon; Paul B Romesser; Benjamin Leach; Teng Han; ...
    Publisher: Nature Publishing Group
    Project: NIH | A scalable platform for t... (1R01CA195787-01), SNSF | GENETICS AND EPIGENETICS ... (P2BEP3_152100), NIH | Modeling metastatic color... (5F30CA200110-02), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Defining the genetic requ... (5K22CA181280-02), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    Colorectal cancer (CRC) is a leading cause of death in the developed world, yet facile preclinical models that mimic the natural stages of CRC progression are lacking. Through the orthotopic engraftment of colon organoids we describe a broadly usable immunocompetent CRC...

  • publication . Article . 2019
    Open Access
    Authors:
    Matthew A. Loberg; Rebecca K. Bell; Leslie O. Goodwin; Elizabeth Eudy; Linde A. Miles; Jennifer M. SanMiguel; Kira Young; David E. Bergstrom; Ross L. Levine; Rebekka K. Schneider; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aging-induced Alterations... (1R56DK112947-01A1), NIH | (PQB5) Epigenetic Drivers... (5R21CA184851-02), NIH | Developing Effective Appr... (1R01DK118072-01), NIH | Synergistic role of signa... (1R35CA197594-01A1), NIH | "Developmental Genetics" (5T32HD007065-27), NIH | Administrative Core (2P30AG038070-06), NIH | Cancer Center Support (CO... (3P30CA034196-26S1), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04)

    textabstractClonal hematopoiesis (CH) is a common aging-associated condition with increased risk of hematologic malignancy. Knowledge of the mechanisms driving evolution from CH to overt malignancy has been hampered by a lack of in vivo models that orthogonally activate...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Craig M. Bielski; Ahmet Zehir; Alexander V. Penson; Mark T. A. Donoghue; Walid Chatila; Joshua Armenia; Matthew T. Chang; Alison M. Schram; Philip Jonsson; Chaitanya Bandlamudi; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Understanding Long Tail D... (5R01CA204749-03), NIH | Targeting AKT-Mutant Huma... (1R01CA207244-01), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04)

    Ploidy abnormalities are a hallmark of human cancers, but their impact on the evolution and outcomes of cancers is unknown. Here, we identified whole-genome doubling (WGD) in the tumors of nearly 30% of 9,692 prospectively sequenced advanced cancer patients. WGD varied ...

  • publication . Article . 2018
    Open Access
    Authors:
    Craig McCarthy;
    Publisher: Frontiers Media SA
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04)

    Patient-derived xenograft (PDX) models have recently emerged as a highly desirable platform in oncology and are expected to substantially broaden the way in vivo studies are designed and executed and to reshape drug discovery programs. However, acquisition of patient-de...

13 research outcomes, page 1 of 2
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