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5 research outcomes, page 1 of 1
  • publication . Preprint . Article . 2017
    Open Access English
    Authors:
    Kavitha Ramaswamy; Lauren Forbes; Gerard Minuesa; Tatyana Gindin; Fiona Brown; Michael G. Kharas; Andrei V. Krivtsov; Scott A. Armstrong; Eric Still; Elisa de Stanchina; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Characterizing MSI2 in le... (5R01CA193842-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Phosphoproteomic signatur... (5R21CA188881-02), NIH | Aberrant signaling in acu... (5R01CA204396-03), NIH | Uncovering the role for M... (5R01DK101989-03), NIH | Epigenetic mechanisms of ... (1K08CA191091-01A1), NIH | Predoctoral Training in P... (1T32GM073546-01A1)

    Aberrant gene expression is a hallmark of acute leukemias. MYB-driven transcriptional coactivation with CREB-binding protein (CBP)/P300 is required for acute lymphoblastic and myeloid leukemias, including refractory MLL-rearranged leukemias. Using structure-guided molec...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Samie Jaffrey; Ly Vu;
    Publisher: Elsevier BV
    Project: NIH | Uncovering the role for M... (5R01DK101989-03), NIH | Identification of therape... (1R01CA225231-01), NIH | Characterizing MSI2 in le... (5R01CA193842-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Control of cap-independen... (5R01CA186702-03), NIH | Shapeshifters in Cancer: ... (1DP2CA239065-01), NIH | The role of DNA methylati... (1R01HL145283-01), NIH | Molecular and genetic ana... (5R01HL135564-03), NIH | Translational Regulation ... (1K99CA229993-01)

    In Brief Cheng et al. uncover RNA methylation as a guardian in hematopoietic stem cell (HSC) fate decisions. m6A maintains hematopoietic stem cell symmetric commitment and identity. This study may provide a general mechanism for how RNA methylation controls cellular fat...

  • publication . Article . 2016
    Open Access English
    Authors:
    Christopher Lengner; Benjamin Durham; Ly Vu;
    Publisher: Nature Publishing Group
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Uncovering the role for M... (5R01DK101989-03), NIH | Characterizing MSI2 in le... (1R01CA193842-01)

    Several studies have recently demonstrated the role of the MSI2 RNA binding protein in normal and malignant haematopoietc stem cells. In this study, the authors show that MSI2 is required for maintaining myelodysplastic syndrome stem cells in mice and that MSI2 expressi...

  • publication . Article . 2017
    Open Access English
    Authors:
    Vu, Ly P.; Pickering, Brian F.; Cheng, Yuanming; Zaccara, Sara; Nguyen, Diu; Minuesa, Gerard; Chou, Timothy; Chow, Arthur; Saletore, Yogesh; MacKay, Matthew; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Uncovering the role for M... (5R01DK101989-03), NIH | CANCER PHARMACOLOGY (5T32CA062948-09), NIH | Characterizing MSI2 in le... (1R01CA193842-01), NIH | Control of cap-independen... (5R01CA186702-03)

    N6-methyladenosine (m6A) is an abundant nucleotide modification in mRNA that is required for the differentiation of mouse embryonic stem cells. However, it remains unknown whether m6A controls differentiation of normal and/or malignant myeloid hematopoietic cells. Here ...

  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Marcus Järås; Cem Meydan; Sagar Chhangawala; Ly Vu; Leandro Cerchietti; Javier Perales-Patón;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Characterizing MSI2 in le... (1R01CA193842-01), NIH | ECOG Specimen Banking (3U24CA114737-05S1), NIH | ECOG-ACRIN INTEGRATED LEU... (5U10CA180827-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Uncovering the role for M... (5R01DK101989-03)

    Michael Kharas and colleagues characterize the MSI2 protein interactome in leukemia cells and subsequently perform a functional screen identifying 24 genes required for leukemia in vivo. They focus on the RNA-binding protein SYNCRIP, showing that it regulates Hoxa9 and ...

5 research outcomes, page 1 of 1
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