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4 research outcomes, page 1 of 1
  • publication . Preprint . 2018
    Open Access
    Authors:
    Chen, Shi; Wiewiora, Rafal P.; Meng, Fanwang; Babault, Nicolas; Ma, Anqi; Yu, Wenyu; Qian, Kun; Hu, Hao; Zou, Hua; Wang, Junyi; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NSERC , NIH | Discovery of Selective In... (5R01GM122749-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanism and Inhibition ... (5R01GM126154-02), NIH | The role of reorganizatio... (5R01GM121505-02), EC | ULTRA-DD (115766), WT , NIH | Targeting Lysine Methyltr... (5R01CA218600-02), NIH | Epigenetic Therapy and Pr... (5R01HD088626-02), NIH | Profile substrates and in... (1R01GM096056-01)

    <jats:title>Abstract</jats:title><jats:p>Elucidating conformational heterogeneity of proteins is essential for understanding protein functions and developing exogenous ligands for chemical perturbation. While structural biology methods can provide atomic details of stat...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Shi Chen; Rafal P Wiewiora; Fanwang Meng; Nicolas Babault; Anqi Ma; Wenyu Yu; Kun Qian; Hao Hu; Hua Zou; Junyi Wang; ...
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | Mechanism and Inhibition ... (5R01GM126154-02), NIH | The role of reorganizatio... (5R01GM121505-02), NIH | MOUSE GENETICS (2P30CA008748-43), NSERC , EC | ULTRA-DD (115766), NIH | Discovery of Selective In... (5R01GM122749-02), NIH | Profile substrates and in... (1R01GM096056-01), WT , NIH | Interrogating Functions o... (1R01GM120570-01)

    Elucidating the conformational heterogeneity of proteins is essential for understanding protein function and developing exogenous ligands. With the rapid development of experimental and computational methods, it is of great interest to integrate these approaches to illu...

  • publication . Article . 2014
    Open Access English
    Authors:
    Gil Blum; Glorymar Ibáñez; Xiangjun Rao; David Shum; Constantin Radu; Hakim Djaballah; Judd C. Rice; Minkui Luo;
    Publisher: American Chemical Society
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Enzyme-engineering Approa... (1DP2OD007335-01), NIH | Molecular mechanisms of g... (1R01GM075094-01A2), NIH | Developing High Throughpu... (1R21NS071520-01A1), NIH | Profile substrates and in... (1R01GM096056-01)

    SETD8/SET8/Pr-SET7/KMT5A is the sole protein lysine methyltransferase (PKMT) known to monomethylate lysine 20 of histone H4 in vivo. SETD8’s methyltransferase activity has been implicated in many essential cellular processes including DNA replication, DNA damage respons...

  • publication . Other literature type . Preprint . Article . 2019
    Open Access
    Authors:
    Xiao-Chuan Cai; Tuo Zhang; Eui-jun Kim; Ming Jiang; Ke Wang; Junyi Wang; Shi Chen; Nawei Zhang; Hong Wu; Fengling Li; ...
    Publisher: eLife Sciences Publications, Ltd
    Project: NSERC , NIH | Protein Arginine Methylat... (1R01CA213293-01), EC | ULTRA-DD (115766), NIH | Statistical Evaluation an... (1R21CA214845-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), WT , NIH | Interrogating Functions o... (1R01GM120570-01), NIH | Protein Arginine Methylat... (1R01CA236356-01), NIH | Profile substrates and in... (1R01GM096056-01)

    CARM1 is a cancer-relevant protein arginine methyltransferase that regulates many aspects of transcription. Its pharmacological inhibition is a promising anti-cancer strategy. Here SKI-73 (6a in this work) is presented as a CARM1 chemical probe with pro-drug properties....

4 research outcomes, page 1 of 1
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