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5 research outcomes, page 1 of 1
  • publication . Doctoral thesis . 2012
    Open Access English
    Authors:
    Ruggiero, Alessandro;
    Publisher: Erasmus University Rotterdam
    Project: NIH | Molecular Imaging: Traini... (1R25CA096945-01), NIH | MOUSE GENETICS (2P30CA008748-43)

    textabstractThe blurring of the boundaries between the disciplines of engineering and the biological sciences has revolutionized medicine. Medicine is still a science of decisionmaking under uncertainty. However, during the past 30 years, this uncertainty gradually dimi...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Naga Vara Kishore Pillarsetty; Jason Lewis;
    Publisher: American Chemical Society (ACS)
    Project: NIH | Characterization of human... (2R42CA128362-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Bioorthogonal Strategies ... (1K25EB016673-01), NIH | Molecular Imaging: Traini... (1R25CA096945-01), NIH | Pretargeted Radioimmunoth... (4R00CA178205-02), NIH | Developing an Anti-sialyl... (5F32CA180452-03)

    A first-of-its-kind 18F pretargeted PET imaging approach based on the bioorthogonal inverse electron demand Diels–Alder (IEDDA) reaction between tetrazine (Tz) and trans-cyclooctene (TCO) is presented. As proof-of-principle, a TCO-bearing immunoconjugate of the anti-CA1...

  • publication . Other literature type . Article . 2014
    Open Access
    Authors:
    Kenneth Pitter;
    Publisher: American Chemical Society (ACS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Molecular Imaging: Traini... (1R25CA096945-01), NIH | MRI-Photoacoustic-Raman N... (1R01EB017748-01A1)

    The current difficulty in visualizing the true extent of malignant brain tumors during surgical resection represents one of the major reasons for the poor prognosis of brain tumor patients. Here, we evaluated the ability of a hand-held Raman scanner, guided by surface-e...

  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Darren R. Veach; Joseph Osborne; Daniel E. Spratt;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Immuno-PET With Anti-PSMA... (1R21CA153177-01A1), NIH | Molecular Imaging: Traini... (1R25CA096945-01), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10), NIH | Image Analysis and Biosta... (5P50CA086438-08), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    Background We applied a non-linear immunokinetic model to quantitatively compare absolute antibody uptake and turnover in subcutaneous LNCaP human prostate cancer (PCa) xenografts of two radiolabeled forms of the humanized anti-prostate-specific membrane antigen (PSMA) ...

  • publication . Article . 2012
    Open Access
    Authors:
    Jason Lewis; Jason P. Holland; Samuel Rice;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Molecular Imaging: Traini... (1R25CA096945-01), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    A non-invasive technology that quantitatively measures the activity of oncogenic signaling pathways could broadly impact cancer diagnosis and treatment using targeted therapies. Here we describe the development of 89Zr-desferrioxamine transferrin (89Zr-Tf), a novel posi...

5 research outcomes, page 1 of 1
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