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  • publication . Other literature type . Article . 2011
    Open Access
    Authors:
    Eric C. Sorenson; Hebroon Obaid; Jedd D. Wolchok; Tianhua Guo; Ferdinand Rossi; Jianda Yuan; Shan Zeng; Rachel Popow; Lee M. Ocuin; James P. Allison; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Administrative Core (5P50CA140146-04), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | A Mouse Model for Human G... (5R01CA102774-04), NIH | PI 3-KINASE AND KIT RECEP... (5R01HL055748-03), NIH | Molecular Mechanisms in G... (7R01CA102613-12)

    Imatinib mesylate targets mutated KIT oncoproteins in gastrointestinal stromal tumor (GIST) and produces a clinical response in 80% of patients. The mechanism is believed to depend predominantly on the inhibition of KIT-driven signals for tumor-cell survival and prolife...

1 research outcomes, page 1 of 1