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3 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Sabio, Erich; Chan, Timothy A.;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Elucidating genetics of r... (1R01CA205426-01A1), NIH | Towards Precision Immuno-... (1R35CA232097-01)

    Editorial summary Immune checkpoint blockade therapy can elicit robust and durable responses in a variety of cancer types. While many patients do not respond, recent reports highlight a distinct group of patients whose tumors undergo rapid growth, leading to progressive...

  • publication . Article . 2019
    Open Access
    Authors:
    Wang, Jingming; Linxweiler, Maximilian; Yang, Wei; Chan, Timothy A.; Morris, Luc G.T.;
    Publisher: Impact Journals, LLC
    Project: NIH | Identifying and targeting... (1R01DE027738-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Elucidating genetics of r... (1R01CA205426-01A1), NIH | Functionalizing recurrent... (1K08DE024774-01)

    The mutagenic effects of tobacco smoking increase the risk of the development of cancers of the lung, head and neck, and other anatomic sites. In a comparison of squamous cell carcinomas of the lung and the head and neck, we find that the immunomodulatory effects of smo...

  • publication . Article . 2019
    Open Access English
    Authors:
    Wang, Weimin; Green, Michael; Choi, Jae Eun; Gijón, Miguel; Kennedy, Paul D.; Johnson, Jeffrey K.; Liao, Peng; Lang, Xueting; Kryczek, Ilona; Sell, Amanda; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Novel immunosupressive ma... (5R01CA123088-05), NIH | Human Tregs in Ovarian Ca... (5R01CA099985-02), NIH | University of Michigan Co... (3P30CA046592-23S1), NIH | Elucidating genetics of r... (1R01CA205426-01A1), NIH | Towards Precision Immuno-... (1R35CA232097-01), NIH | Memory T Cells in the Tum... (5R01CA152470-02), NIH | Human-Enzyme Mediated, Sy... (1R01CA189623-01), NIH | MDSCs in Ovarian Cancer (5R01CA193136-02)

    Summary Cancer immunotherapy restores and/or enhances effector function of CD8+ T cells in the tumor microenvironment1,2. CD8+ T cells activated by cancer immunotherapy execute tumor clearance mainly by inducing cell death through perforin-granzyme- and Fas/Fas ligand-p...

3 research outcomes, page 1 of 1
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