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  • publication . Article . 2019
    Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association.
    Open Access English
    Authors:
    Gini F. Fleming; B.D. Green; Kyle Hernandez; Kathleen R. Bowie; Caroline R. Kim; Mayra A. Betancourt-Ponce; Eva Tonsing-Carter; Ryan V. Harkless; Sarat Chandarlapaty; Diana C. West-Szymanski; ...
    doi: 10.1186/s13058-019-1164-6
    pmc: PMC6651939
    pmid: 31340854
    Publisher: BMC
    Project: NIH | Investigate the role of T... (1R01CA196648-01A1), NIH | Therapeutic approaches to... (1R01CA204999-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Glucocorticoid receptor-m... (5R01CA089208-08), NIH | Cancer Center Support Gra... (3P30CA014599-36S1)

    Background Non-ER nuclear receptor activity can alter estrogen receptor (ER) chromatin association and resultant ER-mediated transcription. Consistent with GR modulation of ER activity, high tumor glucocorticoid receptor (GR) expression correlates with improved relapse-...

1 research outcomes, page 1 of 1