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3 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Christopher Lima; Shaun Olsen; Michaelyn C. Lux; Zachary Hann;
    Publisher: Proceedings of the National Academy of Sciences
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Rational Design of Adenyl... (5R01GM100477-08), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Structural studies of RNA... (1R35GM118080-01), NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), NIH | Structural and Functional... (5R01GM079196-07), NIH | Structural Studies of SUM... (5R01GM065872-12)

    Significance Posttranslational protein modification by ubiquitin (Ub) regulates aspects of biology, including protein turnover and the cell cycle. Proteins and enzymes that promote Ub conjugation are therapeutic targets because they are sometimes dysregulated in cancer,...

  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Laurent Cappadocia; Christopher D. Lima;
    Publisher: American Chemical Society (ACS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01), NIH | Structural Studies of SUM... (5R01GM065872-12)

    Ubiquitin-like proteins (Ubl’s) are conjugated to target proteins or lipids to regulate their activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin, conjugation is achieved through a cascade of activities that are catalyzed ...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Christopher Lima; Frederick C. Streich Jr.;
    Project: NIH | Structural Studies of SUM... (5R01GM065872-12), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01), NIH | Pixel Array Detector for ... (1S10RR029205-01)

    Post-translational protein modification by ubiquitin (Ub) and ubiquitin-like (Ubl) proteins such as small ubiquitin-like modifier (SUMO) regulates processes including protein homeostasis, the DNA damage response, and the cell cycle. Proliferating cell nuclear antigen (P...

3 research outcomes, page 1 of 1
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