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7 research outcomes, page 1 of 1
  • publication . Article . 2015
    Open Access English
    Authors:
    Jolanta Lissowska; Carlotta Sacerdote; FULVIO RICCERI; Christine Friedenreich; Sara Olson; Veronica Setiawan; Amanda Spurdle; Anne Zeleniuch-Jacquotte; Elisabete Weiderpass;
    Publisher: Nature Publishing Group
    Project: NIH | GENETIC SUSCEPTIBILITY TO... (5R01CA082838-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | SURVEILLANCE, EPIDEMIOLOG... (N01CN067001-000), NIH | Vitamin D, Related Genes ... (2R01CA098661-06A2), NIH | Soyfood, gene polymorphis... (5R01CA092585-05), NIH | EPIDEMIOLOGIC STUDIES OF ... (5P01CA033619-05), NIH | DISTRIBUTION OF BODY FAT ... (3R01CA039742-11S1), NIH | Experimental Pathology (5P30CA016087-32), NIH | COLLABORATIVE STUDY OF OV... (5R01CA058598-05), NIH | CASE-CONTROL STUDY OF POS... (5R01CA048774-04),...

    Background: Nulliparity is an endometrial cancer risk factor, but whether or not this association is due to infertility is unclear. Although there are many underlying infertility causes, few studies have assessed risk relations by specific causes. Methods: We conducted ...

  • publication . Preprint . Article . Other literature type . 2017
    Open Access
    Authors:
    Jelinic, Petar; Ricca, Jacob; Oudenhove, Elke Van; Olvera, Narciso; Merghoub, Taha; Levine, Douglas A.; Zamarin, Dmitriy;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Experimental Pathology (5P30CA016087-32), NIH | MOUSE GENETICS (2P30CA008748-43)

    <jats:title>Abstract</jats:title><jats:p>Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a highly aggressive monogenic cancer driven by <jats:italic>SMARCA4</jats:italic> mutations. Here, we report responses to anti-PD1 immunotherapy in four patients a...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Kasthuri Kannan; David Capper; David T. W. Jones; Igor Dolgalev; Dimitris Placantonakis; Sarah LeBoeuf; Jeffrey Wisoff; Matija Snuderl; Matthias Karajannis; sharon gardner; ...
    Publisher: Nature Publishing Group
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Experimental Pathology (5P30CA016087-32), NIH | Sandy Recovery Ventana Me... (1S10OD018338-01)

    Pineoblastoma is a highly aggressive and rare childhood brain cancer, and the genetic drivers of sporadic pineoblastoma are unknown. Here, the authors genomically interrogated pediatric and adult pineoblastomas and found novel variants including recurrent homozygous del...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Alison P. Klein; Brian M. Wolpin; Harvey A. Risch; Rachael Z. Stolzenberg-Solomon; Evelina Mocci; Mingfeng Zhang; Federico Canzian; Erica J. Childs; Jason W. Hoskins; Ashley Jermusyk; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Womens Health Study: Cont... (1R01HL080467-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Vitamin D, Related Genes ... (2R01CA098661-06A2), NIH | Experimental Pathology (5P30CA016087-32), NIH | Pancreatic Cancer Genetic... (5R01CA097075-05), NIH | TRIAL OF ASPIRIN AND VITA... (5R01HL043851-08), NIH | PANCREATIC CANCER CASE CO... (3R01CA059706-01A1S1), NIH | Cancer Epidemiology Cohor... (5UM1CA167552-02), NIH | CALIFORNIA COORDINATED CA... (1U58DP003862-01), NIH | The Womens Health Study: ... (1RC1HL099355-01),...

    In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Yu Matsuzawa-Ishimoto; Yusuke Shono; Luis E. Gomez; Vanessa M. Hubbard-Lucey; Michael Cammer; Jessica Neil; M. Zahidunnabi Dewan; Sophia R. Lieberman; Amina Lazrak; Jill M. Marinis; ...
    Publisher: The Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Experimental Pathology (5P30CA016087-32), NIH | Role of Nod2 in preventin... (5R01DK103788-03), NIH | Strategies to enhance imm... (5R01HL069929-12), NIH | Strategies to Enhance Lym... (5R01AI080455-02), NIH | Redefining the role of au... (5R01AI121244-03), NIH | Characterization of a com... (5R01DK093668-08), NIH | IL-22 in Thymic Regenerat... (5R01AI101406-02), NIH | The role of autophagy gen... (1R01HL123340-01A1), NIH | Mucosal Immunity and Micr... (9R01AI100288-06A1)

    Matsuzawa-Ishimoto et al. show that autophagy gene ATG16L1, which is associated with inflammatory diseases of the gastrointestinal tract, is essential for preventing necroptotic cell death and loss of Paneth cells in the intestinal epithelium.

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Dajun Sang; Sudarshan Pinglay; Rafal P Wiewiora; Myvizhi E Selvan; Hua Jane Lou; John D Chodera; Benjamin E Turk; Zeynep H Gümüş; Liam J Holt;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | Experimental Pathology (5P30CA016087-32), NIH | The role of reorganizatio... (5R01GM121505-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Modeling human phosphoryl... (1R01GM104047-01A1)

    <jats:p>Protein kinases are crucial to coordinate cellular decisions and therefore their activities are strictly regulated. Previously we used ancestral reconstruction to determine how CMGC group kinase specificity evolved (Howard et al., 2014). In the present study, we...

  • publication . Preprint . 2020
    Open Access
    Authors:
    Ngo, Bryan; Kim, Eugenie; Osorio-Vasquez, Victoria; Doll, Sophia; Bustraan, Sophia; Luengo, Alba; Davidson, Shawn M.; Ali, Ahmed; Ferraro, Gino D.; Kang, Diane; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Understanding the role of... (5R21CA198028-02), NIH | Core--Bioengineering (1P01CA080124-01A1), NIH | Transport of Large Molecu... (5R01CA098706-08), NIH | Characterizing the role o... (5K22CA175228-02), NIH | The role of chromosomal i... (1DP5OD026395-01), NIH | Experimental Pathology (5P30CA016087-32), NIH | Regulation of glucose met... (1R01CA168653-01A1), EC | MSmed (686547), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Integrative Biology of Tu... (5R01CA085140-07),...

    <jats:title>Abstract</jats:title><jats:p>A hallmark of metastasis is the adaptation of tumor cells to new environments. Although it is well established that the metabolic milieu of the brain is severely deprived of nutrients, particularly the amino acids serine and its ...

7 research outcomes, page 1 of 1
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