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11 research outcomes, page 1 of 2
  • publication . Article . 2017
    Open Access English
    Authors:
    Cho, Christina; Hsu, Meier; Barba, Pere; Maloy, Molly A.; Avecilla, Scott T.; Barker, Juliet N.; Castro-Malaspina, Hugo; Giralt, Sergio A.; Jakubowski, Ann A.; Koehne, Guenther; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14)

    Altres ajuts: This research was supported in part by National Institutes of Health award number P01 CA23766 and NIH/NCI Cancer Center Support Grant P30 CA008748. The content is solely the responsibility of the authors and does not necessarily represent the official view...

  • publication . Other literature type . Preprint . 2019
    Open Access
    Authors:
    Sejal Morjaria; Allen W. Zhang; Sohn Kim; Jonathan U. Peled; Simone Becattini; Eric R. Littmann; Eric. G. Pamer; Miguel-Angel Perales; Michael C. Abt;
    Publisher: bioRxiv
    Project: NIH | Systems Biology of Microb... (5U01AI124275-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | Endothelial cells regulat... (1R01CA228358-01), NIH | Immune-Microbiota Interac... (4R00AI125786-03), NIH | Mathematical ecology mode... (1R01AI137269-01A1)

    <jats:title>Background</jats:title><jats:p>Monocytes are an essential cellular component of the innate immune system that support the host’s effectivenss to combat a range of infectious pathogens. Hemopoietic cell transplantation (HCT) results in transient monocyte depl...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Ron Gejman; ming li; Jonathan Coleman;
    Publisher: Springer Nature
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | Biology of Alpha Particle... (2R01CA055349-16A2), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | Immunoediting in Human Ca... (5F30CA200327-04), NIH | Core_Training (2P41GM103504-06), NIH | MSKCC Center for Translat... (5U24CA143840-04), NIH | Urologic Oncology Researc... (5T32CA082088-13)

    Background Tumor-infiltrating immune cells have been linked to prognosis and response to immunotherapy; however, the levels of distinct immune cell subsets and the signals that draw them into a tumor, such as the expression of antigen presenting machinery genes, remain ...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Noah Shroyer; Jarrod Dudakov; Marco Calafiore; Enrico Velardi; Michal Mokry; Maria Laura Martin; Ya-Yuan Fu;
    Project: NIH | Strategies to enhance imm... (5R01HL069929-12), EC | STROMA (289720), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | IL-22 in Thymic Regenerat... (5R01AI101406-02), NIH | Investigating the role of... (1K99CA176376-01), NIH | Strategies to Enhance Lym... (5R01AI080455-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Regulation of the intesti... (5R01HL125571-03), NIH | IL-22 in epithelial regen... (1K08HL115355-01), NIH | Mucosal Immunity and Micr... (9R01AI100288-06A1)

    Epithelial regeneration is critical for barrier maintenance and organ function after intestinal injury. The intestinal stem cell (ISC) niche provides Wnt, Notch, and epidermal growth factor (EGF) signals supporting Lgr5+ crypt base columnar ISCs for normal epithelial ma...

  • publication . Preprint . Article . Other literature type . 2019
    Open Access
    Authors:
    Morjaria, Sejal; Schluter, Jonas; Taylor, Bradford P.; Littmann, Eric R.; Carter, Rebecca A.; Fontana, Emily; Peled, Jonathan U.; van den Brink, Marcel R.M.; Xavier, Joao B.; Taur, Ying;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Systems Biology of Microb... (5U01AI124275-03), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | Endothelial cells regulat... (1R01CA228358-01)

    Dramatic microbiota changes and loss of commensal anaerobic bacteria are associated with adverse outcomes in hematopoietic cell transplantation (HCT) recipients. In this study, we demonstrate these dynamic changes at high resolution through daily stool sampling and asse...

  • publication . Article . 2017
    Open Access English
    Authors:
    Julius C. Fischer; Michael Bscheider; Gabriel Eisenkolb; Chia-Ching Lin; Alexander Wintges; Vera Otten; Caroline A. Lindemans; Simon Heidegger; Martina Rudelius; Sébastien Monette; ...
    Project: NIH | Strategies to enhance imm... (5R01HL069929-12), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | IL-22 in Thymic Regenerat... (5R01AI101406-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Strategies to Enhance Lym... (5R01AI080455-02), EC | CBM-INNATE (322865), NIH | Mucosal Immunity and Micr... (9R01AI100288-06A1)

    The molecular pathways that regulate the tissue repair function of type I interferon (IFN-I) during acute tissue damage are poorly understood. We describe a protective role for IFN-I and the RIG-I/MAVS signaling pathway during acute tissue damage in mice. Mice lacking m...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Florent Malard; Jakob R Passweg;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14)

    Background Graft-versus-host disease (GVHD) is one of the leading causes of non-relapse mortality and morbidity after allogeneic hematopoietic stem cell transplantation (allo-HCT). Methods We evaluated the outcomes of two well-established strategies used for GVHD preven...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Andrea Z. Tuckett; Raymond H. Thornton; Richard J. O’Reilly; Marcel R. M. van den Brink; Johannes L. Zakrzewski;
    Publisher: BioMed Central
    Project: EC | THYMISTEM (602587), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Strategies to enhance imm... (5R01HL069929-12), NIH | IL-22 in Thymic Regenerat... (5R01AI101406-02), NIH | Mucosal Immunity and Micr... (9R01AI100288-06A1), NIH | Strategies to enhance thy... (1K08CA160659-01), NIH | The role of autophagy gen... (1R01HL123340-01A1)

    Background Even though hematopoietic stem cell transplantation can be curative in patients with severe combined immunodeficiency, there is a need for additional strategies boosting T cell immunity in individuals suffering from genetic disorders of lymphoid development. ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Keith, James W.; Pamer, Eric G.;
    Publisher: Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Innate Immune Defense aga... (5R01AI095706-03), NIH | Systems Biology of Microb... (5U01AI124275-03), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | TNF Mediated Immune Defen... (5R01AI042135-09)

    The emergence of antibiotic-resistant bacterial pathogens is an all-too-common consequence of antibiotic use. Although antibiotic resistance among virulent bacterial pathogens is a growing concern, the highest levels of antibiotic resistance occur among less pathogenic ...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Ron S Gejman; Aaron Y Chang; Heather F Jones; Krysta DiKun; Abraham Ari Hakimi; Andrea Schietinger; David A Scheinberg;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | Biology of Alpha Particle... (2R01CA055349-16A2), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | Immunoediting in Human Ca... (5F30CA200327-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Spatiotemporal regulation... (1DP2CA225212-01)

    [u'T cells are specialized agents of the immune system that can detect and attack tumors. They spot their target by identifying small pieces of proteins \u2013 or antigens \u2013 at the surface of diseased cells. In particular, they can recognize the new and abnormal an...

11 research outcomes, page 1 of 2
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