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5 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Danussi, Carla; Bose, Promita; Parthasarathy, Prasanna T.; Silberman, Pedro C.; Van Arnam, John S.; Vitucci, Mark; Tang, Oliver Y.; Heguy, Adriana; Wang, Yuxiang; Chan, Timothy A.; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), CIHR , NIH | Cancer Center Support (CO... (3P30CA016672-41S4), NIH | Credentialing murine mode... (5R01CA204136-02)

    ATRX inactivation frequently occurs in glioma. Here, the authors explore the role of ATRX inactivation in oncogenesis, highlighting ATRX deficiency driven epigenomic changes that influence the expression of genes crucial to the oncogenic phenotype.

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Emiliano Calvo; Sarina Piha-Paul; Sherene Loi; Victor Moreno;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | ERBB2 TARGETED ANTITUMOR ... (5R01CA080195-04), NIH | Cancer Center Support (CO... (3P30CA016672-41S4), NIH | Understanding Long Tail D... (5R01CA204749-03), NIH | Informatics to enable rou... (5U01CA180964-02), NIH | Cancer Chemotherapy Train... (5T32CA009207-29), NIH | SPORE in Breast Cancer (3P50CA098131-15S1), NIH | Center for Clinical and T... (4UL1TR000371-10), NIH | USC COMPREHENSIVE CANCER ... (3P30CA014089-17S1)

    Somatic mutations of ERBB2 and ERBB3 (which encode HER2 and HER3, respectively) are found in a wide range of cancers. Preclinical modelling suggests that a subset of these mutations lead to constitutive HER2 activation, but most remain biologically uncharacterized. Here...

  • publication . Article . 2018
    Open Access English
    Authors:
    M. Catherine Pietanza; Saiama N. Waqar; Lee M. Krug; Afshin Dowlati; Christine L. Hann; Alberto Chiappori; Taofeek K. Owonikoko; Kaitlin M. Woo; Robert J. Cardnell; Junya Fujimoto; ...
    Publisher: American Society of Clinical Oncology
    Project: NIH | The Johns Hopkins Transla... (3UM1CA186691-03S3), NIH | Therapeutic strategies fo... (5R01CA207295-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Center Support (CO... (3P30CA016672-41S4), NIH | UNIVERSITY OF TEXAS--SPOR... (3P50CA070907-02S1)

    <jats:sec><jats:title>Purpose</jats:title><jats:p> Both temozolomide (TMZ) and poly (ADP-ribose) polymerase (PARP) inhibitors are active in small-cell lung cancer (SCLC). This phase II, randomized, double-blind study evaluated whether addition of the PARP inhibitor veli...

  • publication . Article . 2018
    Open Access English
    Authors:
    Lehrer, Michael; Bhadra, Anindya; Aithala, Sathvik; Ravikumar, Visweswaran; Zheng, Youyun; Dogan, Basak; Bonaccio, Emerlinda; Burnside, Elizabeth S.; Morris, Elizabeth; Sutton, Elizabeth; ...
    Publisher: Impact Journals LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Synthesizing Image-derive... (1R37CA214955-01A1), NIH | Cancer Center Support (CO... (3P30CA016672-41S4)

    Background Imaging features derived from MRI scans can be used for not only breast cancer detection and measuring disease extent, but can also determine gene expression and patient outcomes. The relationships between imaging features, gene/protein expression, and respon...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Kasthuri Kannan; Rachna Shah; Jie Yang; Erik Sulman;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Cancer Center Support (CO... (3P30CA016672-41S4), NIH | MOUSE GENETICS (2P30CA008748-43)

    Mutational inactivation of ATRX (α-thalassemia mental retardation X-linked) represents a defining molecular alteration in large subsets of malignant glioma. Yet the pathogenic consequences of ATRX deficiency remain unclear, as do tractable mechanisms for its therapeutic...

5 research outcomes, page 1 of 1
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