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PublicationsOpen AccessStrategies to enhance immune recon...MOUSE GENETICSThe role of autophagy gene Atg16L1...
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2 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2017
    Intrathymic injection of hematopoietic progenitor cells establishes functional T cell development in a mouse model of severe combined immunodeficiency
    Open Access English
    Authors:
    Marcel R.M. van den Brink; Andrea Z. Tuckett; Richard J. O'Reilly; Johannes L. Zakrzewski; Raymond H. Thornton;
    doi: 10.1186/s13045-017-0478-z
    pmc: PMC5432974
    pmid: 28511686
    Publisher: BioMed Central
    Project: NIH | Mucosal Immunity and Micr... (9R01AI100288-06A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | The role of autophagy gen... (1R01HL123340-01A1), NIH | Strategies to enhance thy... (1K08CA160659-01), EC | THYMISTEM (602587), NIH | Strategies to enhance imm... (5R01HL069929-12), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | IL-22 in Thymic Regenerat... (5R01AI101406-02)

    Background Even though hematopoietic stem cell transplantation can be curative in patients with severe combined immunodeficiency, there is a need for additional strategies boosting T cell immunity in individuals suffering from genetic disorders of lymphoid development. ...

  • publication . Article . Other literature type . 2017
    Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium.
    Open Access
    Authors:
    Sophia R. Lieberman; Vanessa M. Hubbard-Lucey; Jill M. Marinis; Ken Cadwell; M. Zahidunnabi Dewan; Chen Liu; Luis E. Gomez; Philip A. Harris; Marcel R.M. van den Brink; Marcel R.M. van den Brink; ...
    doi: 10.1084/jem.20170558
    pmc: PMC5716041
    pmid: 29089374
    Publisher: Rockefeller University Press
    Project: NIH | Characterization of a com... (5R01DK093668-08), NIH | Strategies to Enhance Lym... (5R01AI080455-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | The role of autophagy gen... (1R01HL123340-01A1), NIH | Strategies to enhance imm... (5R01HL069929-12), NIH | Role of Nod2 in preventin... (5R01DK103788-03), NIH | Mucosal Immunity and Micr... (9R01AI100288-06A1), NIH | Experimental Pathology (5P30CA016087-32), NIH | IL-22 in Thymic Regenerat... (5R01AI101406-02), NIH | Redefining the role of au... (5R01AI121244-03)

    Matsuzawa-Ishimoto et al. show that autophagy gene ATG16L1, which is associated with inflammatory diseases of the gastrointestinal tract, is essential for preventing necroptotic cell death and loss of Paneth cells in the intestinal epithelium.

2 research outcomes, page 1 of 1