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  • publication . Article . Other literature type . 2017
    Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium.
    Open Access
    Authors:
    Sophia R. Lieberman; Vanessa M. Hubbard-Lucey; Jill M. Marinis; Ken Cadwell; M. Zahidunnabi Dewan; Chen Liu; Luis E. Gomez; Philip A. Harris; Marcel R.M. van den Brink; Marcel R.M. van den Brink; ...
    doi: 10.1084/jem.20170558
    pmc: PMC5716041
    pmid: 29089374
    Publisher: Rockefeller University Press
    Project: NIH | Characterization of a com... (5R01DK093668-08), NIH | Strategies to Enhance Lym... (5R01AI080455-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | The role of autophagy gen... (1R01HL123340-01A1), NIH | Strategies to enhance imm... (5R01HL069929-12), NIH | Role of Nod2 in preventin... (5R01DK103788-03), NIH | Mucosal Immunity and Micr... (9R01AI100288-06A1), NIH | Experimental Pathology (5P30CA016087-32), NIH | IL-22 in Thymic Regenerat... (5R01AI101406-02), NIH | Redefining the role of au... (5R01AI121244-03)

    Matsuzawa-Ishimoto et al. show that autophagy gene ATG16L1, which is associated with inflammatory diseases of the gastrointestinal tract, is essential for preventing necroptotic cell death and loss of Paneth cells in the intestinal epithelium.

1 research outcomes, page 1 of 1