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3 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2015
    Open Access
    Authors:
    Maria Laura Martin; Enrico Velardi; Margaret O'Connor; Kevin P. O’Rourke; Shuichiro Takashima; Lukas E. Dow; Gillian Lawrence; Odette M. Smith; Edward E. S. Nieuwenhuis; Yuan-Hung Lo; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Strategies to Enhance Lym... (5R01AI080455-02), NIH | Investigating the role of... (1K99CA176376-01), NIH | Regulation of the intesti... (5R01HL125571-03), EC | STROMA (289720), NIH | Strategies to enhance imm... (5R01HL069929-12), NIH | Mucosal Immunity and Micr... (9R01AI100288-06A1), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | IL-22 in Thymic Regenerat... (5R01AI101406-02), NIH | IL-22 in epithelial regen... (1K08HL115355-01)

    Epithelial regeneration is critical for barrier maintenance and organ function after intestinal injury. The intestinal stem cell (ISC) niche provides Wnt, Notch, and epidermal growth factor (EGF) signals supporting Lgr5+ crypt base columnar ISCs for normal epithelial ma...

  • publication . Article . 2017
    Open Access
    Authors:
    Alexander Wintges; Ulrich Kalinke; Hendrik Poeck; Hendrik Poeck; Gabriel Eisenkolb; Gabriel Eisenkolb; Stefan Lienenklaus; Melissa D. Docampo; Marcel R.M. van den Brink; Sebastien Monette; ...
    Publisher: American Association for the Advancement of Science (AAAS)
    Project: EC | CBM-INNATE (322865), NIH | Strategies to Enhance Lym... (5R01AI080455-02), NIH | Mucosal Immunity and Micr... (9R01AI100288-06A1), NIH | Strategies to enhance imm... (5R01HL069929-12), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | IL-22 in Thymic Regenerat... (5R01AI101406-02)

    The molecular pathways that regulate the tissue repair function of type I interferon (IFN-I) during acute tissue damage are poorly understood. We describe a protective role for IFN-I and the RIG-I/MAVS signaling pathway during acute tissue damage in mice. Mice lacking m...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Marcel R.M. van den Brink; Andrea Z. Tuckett; Richard J. O'Reilly; Johannes L. Zakrzewski; Raymond H. Thornton;
    Publisher: BioMed Central
    Project: NIH | Mucosal Immunity and Micr... (9R01AI100288-06A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | The role of autophagy gen... (1R01HL123340-01A1), NIH | Strategies to enhance thy... (1K08CA160659-01), EC | THYMISTEM (602587), NIH | Strategies to enhance imm... (5R01HL069929-12), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | IL-22 in Thymic Regenerat... (5R01AI101406-02)

    Background Even though hematopoietic stem cell transplantation can be curative in patients with severe combined immunodeficiency, there is a need for additional strategies boosting T cell immunity in individuals suffering from genetic disorders of lymphoid development. ...

3 research outcomes, page 1 of 1