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2 research outcomes, page 1 of 1
  • publication . Article . 2017
    RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury
    Open Access
    Authors:
    Alexander Wintges; Ulrich Kalinke; Hendrik Poeck; Hendrik Poeck; Gabriel Eisenkolb; Gabriel Eisenkolb; Stefan Lienenklaus; Melissa D. Docampo; Marcel R.M. van den Brink; Sebastien Monette; ...
    doi: 10.1126/scitranslmed.aag2513
    pmc: PMC5604790
    pmid: 28424327
    View all 4 identifiers
    Publisher: American Association for the Advancement of Science (AAAS)
    Project: EC | CBM-INNATE (322865), NIH | Strategies to Enhance Lym... (5R01AI080455-02), NIH | Mucosal Immunity and Micr... (9R01AI100288-06A1), NIH | Strategies to enhance imm... (5R01HL069929-12), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | IL-22 in Thymic Regenerat... (5R01AI101406-02)

    The molecular pathways that regulate the tissue repair function of type I interferon (IFN-I) during acute tissue damage are poorly understood. We describe a protective role for IFN-I and the RIG-I/MAVS signaling pathway during acute tissue damage in mice. Mice lacking m...

  • publication . Other literature type . Article . 2015
    Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration
    Open Access
    Authors:
    Maria Laura Martin; Enrico Velardi; Margaret O'Connor; Kevin P. O’Rourke; Shuichiro Takashima; Lukas E. Dow; Gillian Lawrence; Odette M. Smith; Edward E. S. Nieuwenhuis; Yuan-Hung Lo; ...
    doi: 10.1038/nature16460
    handle: 1765/84635
    pmc: PMC4720437
    View all 4 identifiers
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Strategies to Enhance Lym... (5R01AI080455-02), NIH | Investigating the role of... (1K99CA176376-01), NIH | Regulation of the intesti... (5R01HL125571-03), EC | STROMA (289720), NIH | Strategies to enhance imm... (5R01HL069929-12), NIH | Mucosal Immunity and Micr... (9R01AI100288-06A1), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | IL-22 in Thymic Regenerat... (5R01AI101406-02), NIH | IL-22 in epithelial regen... (1K08HL115355-01)

    Epithelial regeneration is critical for barrier maintenance and organ function after intestinal injury. The intestinal stem cell (ISC) niche provides Wnt, Notch, and epidermal growth factor (EGF) signals supporting Lgr5+ crypt base columnar ISCs for normal epithelial ma...

2 research outcomes, page 1 of 1