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4 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Yu Matsuzawa-Ishimoto; Yusuke Shono; Luis E. Gomez; Vanessa M. Hubbard-Lucey; Michael Cammer; Jessica Neil; M. Zahidunnabi Dewan; Sophia R. Lieberman; Amina Lazrak; Jill M. Marinis; ...
    Publisher: The Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Experimental Pathology (5P30CA016087-32), NIH | Role of Nod2 in preventin... (5R01DK103788-03), NIH | Strategies to enhance imm... (5R01HL069929-12), NIH | Strategies to Enhance Lym... (5R01AI080455-02), NIH | Redefining the role of au... (5R01AI121244-03), NIH | Characterization of a com... (5R01DK093668-08), NIH | IL-22 in Thymic Regenerat... (5R01AI101406-02), NIH | The role of autophagy gen... (1R01HL123340-01A1), NIH | Mucosal Immunity and Micr... (9R01AI100288-06A1)

    Matsuzawa-Ishimoto et al. show that autophagy gene ATG16L1, which is associated with inflammatory diseases of the gastrointestinal tract, is essential for preventing necroptotic cell death and loss of Paneth cells in the intestinal epithelium.

  • publication . Article . 2017
    Open Access English
    Authors:
    Julius C. Fischer; Michael Bscheider; Gabriel Eisenkolb; Chia-Ching Lin; Alexander Wintges; Vera Otten; Caroline A. Lindemans; Simon Heidegger; Martina Rudelius; Sébastien Monette; ...
    Project: NIH | Strategies to enhance imm... (5R01HL069929-12), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | IL-22 in Thymic Regenerat... (5R01AI101406-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Strategies to Enhance Lym... (5R01AI080455-02), EC | CBM-INNATE (322865), NIH | Mucosal Immunity and Micr... (9R01AI100288-06A1)

    The molecular pathways that regulate the tissue repair function of type I interferon (IFN-I) during acute tissue damage are poorly understood. We describe a protective role for IFN-I and the RIG-I/MAVS signaling pathway during acute tissue damage in mice. Mice lacking m...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Andrea Z. Tuckett; Raymond H. Thornton; Richard J. O’Reilly; Marcel R. M. van den Brink; Johannes L. Zakrzewski;
    Publisher: BioMed Central
    Project: EC | THYMISTEM (602587), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Strategies to enhance imm... (5R01HL069929-12), NIH | IL-22 in Thymic Regenerat... (5R01AI101406-02), NIH | Mucosal Immunity and Micr... (9R01AI100288-06A1), NIH | Strategies to enhance thy... (1K08CA160659-01), NIH | The role of autophagy gen... (1R01HL123340-01A1)

    Background Even though hematopoietic stem cell transplantation can be curative in patients with severe combined immunodeficiency, there is a need for additional strategies boosting T cell immunity in individuals suffering from genetic disorders of lymphoid development. ...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Noah Shroyer; Jarrod Dudakov; Marco Calafiore; Enrico Velardi; Michal Mokry; Maria Laura Martin; Ya-Yuan Fu;
    Project: NIH | Strategies to enhance imm... (5R01HL069929-12), EC | STROMA (289720), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | IL-22 in Thymic Regenerat... (5R01AI101406-02), NIH | Investigating the role of... (1K99CA176376-01), NIH | Strategies to Enhance Lym... (5R01AI080455-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Regulation of the intesti... (5R01HL125571-03), NIH | IL-22 in epithelial regen... (1K08HL115355-01), NIH | Mucosal Immunity and Micr... (9R01AI100288-06A1)

    Epithelial regeneration is critical for barrier maintenance and organ function after intestinal injury. The intestinal stem cell (ISC) niche provides Wnt, Notch, and epidermal growth factor (EGF) signals supporting Lgr5+ crypt base columnar ISCs for normal epithelial ma...

4 research outcomes, page 1 of 1
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