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5 research outcomes, page 1 of 1
  • publication . Preprint . 2018
    Open Access English
    Authors:
    Sol Shenker; Eric Lai;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | BEN factors are conserved... (5R01NS074037-02), NIH | Non-canonical miRNA bioge... (2R01GM083300-06), NIH | MOUSE GENETICS (2P30CA008748-43)

    <jats:title>Abstract</jats:title><jats:p>The recent beyond-exponential growth in diverse collections of deep sequencing datasets creates enormous opportunities for discovery, concomitant with new challenges for displaying and interpreting these data. Notably, the availa...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Vedanayagam, Jeffrey; Chatila, Walid K.; Aksoy, Bülent Arman; Majumdar, Sonali; Skanderup, Anders Jacobsen; Demir, Emek; Schultz, Nikolaus; Sander, Chris; Lai, Eric C.;
    Publisher: Nature Publishing Group UK
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Non-canonical miRNA bioge... (2R01GM083300-06), NIH | MSKCC Center for Translat... (5U24CA143840-04), NIH | Molecular and genetic ana... (5R01HL135564-03)

    Somatic mutations in the RNase IIIb domain of DICER1 arise in cancer and disrupt the cleavage of 5' pre-miRNA arms. Here, we characterize an unstudied, recurrent, mutation (S1344L) in the DICER1 RNase IIIa domain in tumors from The Cancer Genome Atlas (TCGA) project and...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Samie Jaffrey; Eric Lai; Shu Kondo;
    Publisher: Nature Publishing Group
    Project: NSF | Role of nucleoside modifi... (1412379), NIH | Intercellular Communicati... (1R01GM072562-01A2), NSF | Molecular mechanism of Lg... (1052333), NIH | Non-canonical miRNA bioge... (2R01GM083300-06), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | BEN factors are conserved... (5R01NS074037-02), NIH | Mechanism and regulation ... (2R01NS083833-06), NIH | mRNA methylation: A novel... (5R01DA037150-03)

    N 6-methyladenosine (m6A) is a conserved RNA modification that has recently emerged as an important regulator of messenger RNA processing and activity. Here, the authors provide evidence that m6A pathway facilitates female-specific splicing of Sxl, regulating sex determ...

  • publication . Article . Preprint . 2020
    Open Access
    Authors:
    Garaulet, Daniel L.; Zhang, Binglong; Wei, Lu; Li, Elena; Lai, Eric C.;
    Publisher: Elsevier BV
    Project: NIH | Non-canonical miRNA bioge... (2R01GM083300-06), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanism and regulation ... (2R01NS083833-06)

    <jats:title>Summary</jats:title><jats:p>How are diverse regulatory strategies integrated to impose appropriately patterned gene expression that underlie <jats:italic>in vivo</jats:italic> phenotypes? Here, we reveal how coordinated miRNA regulation and neural-specific a...

  • publication . Article . 2017
    Open Access English
    Authors:
    Eric Lai; Jiayu Wen;
    Publisher: BMC
    Project: NIH | Non-canonical miRNA bioge... (2R01GM083300-06), NIH | MOLECULAR ANALYSIS OF THE... (1F32GM013039-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanism and regulation ... (2R01NS083833-06)

    Background Drosophila melanogaster has one of best-described transcriptomes of any multicellular organism. Nevertheless, the paucity of 3′-sequencing data in this species precludes comprehensive assessment of alternative polyadenylation (APA), which is subject to broad ...

5 research outcomes, page 1 of 1
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