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13 research outcomes, page 1 of 2
  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Alison P. Klein; Brian M. Wolpin; Harvey A. Risch; Rachael Z. Stolzenberg-Solomon; Evelina Mocci; Mingfeng Zhang; Federico Canzian; Erica J. Childs; Jason W. Hoskins; Ashley Jermusyk; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Womens Health Study: Cont... (1R01HL080467-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Vitamin D, Related Genes ... (2R01CA098661-06A2), NIH | Experimental Pathology (5P30CA016087-32), NIH | Pancreatic Cancer Genetic... (5R01CA097075-05), NIH | TRIAL OF ASPIRIN AND VITA... (5R01HL043851-08), NIH | PANCREATIC CANCER CASE CO... (3R01CA059706-01A1S1), NIH | Cancer Epidemiology Cohor... (5UM1CA167552-02), NIH | CALIFORNIA COORDINATED CA... (1U58DP003862-01), NIH | The Womens Health Study: ... (1RC1HL099355-01),...

    In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ...

  • publication . Article . 2014
    Open Access
    Authors:
    Jolanta Lissowska; Carlotta Sacerdote; Fredrick Schumacher; Christine Friedenreich; Maxine Chen; Sara Olson; Veronica Setiawan; Marta Crous-Bou; Irene Orlow;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | ESTROGEN, DIET, GENETICS ... (5R01CA083918-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | GENETIC SUSCEPTIBILITY TO... (5R01CA082838-04), NIH | Genome-Wide Association S... (5R01CA134958-02), NIH | Genetic Variation in Estr... (5R03CA128008-02), NIH | Molecular Epidemiology of... (1R01CA105212-01A1), NIH | Training Program in Cance... (5T32CA009001-38), NIH | DIET, HORMONES AND RISK O... (3P01CA087969-03S1), CIHR , NIH | RESEARCH IN CANCER EPIDEM... (3R35CA039779-09S1),...

    Endometrial cancer (EC) contributes substantially to total burden of cancer morbidity and mortality in the United States. Family history is a known risk factor for EC, thus genetic factors may play a role in EC pathogenesis. Three previous genome-wide association studie...

  • publication . Article . 2019
    Open Access English
    Authors:
    Kim, S.; Wang, M.; Tyrer, J. P.; Jensen, A.; Wiensch, A.; Liu, G.; Lee, A. W.; Ness, R. B.; Salvatore, M.; Tworoger, S. S.; ...
    Project: NIH | ESTROGEN, DIET, GENETICS ... (5R01CA083918-04), NIH | PCOS, Type II diabetes an... (5K22CA193860-03), NIH | Training Grant in Genomic... (5T32ES013678-05), NIH | Steroid Hormone Genes and... (5R01CA112523-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | SURVEILLANCE, EPIDEMIOLOG... (N01CN067001-000), NIH | MOLECULAR EPIDEMIOLOGY OF... (5R01CA076016-04), NIH | Long Term Multidisciplina... (5UM1CA186107-05), NIH | RISK FACTORS AND PROGNOST... (1R01CA061107-01), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01PC067010-000),...

    As a follow-up to genome-wide association analysis of common variants associated with ovarian carcinoma (cancer), this study considers seven well-known ovarian cancer risk factors and their interactions with 28 genome-wide significant common genetic variants. The intera...

  • publication . Article . 2013
    Open Access English
    Authors:
    Jolanta Lissowska; Carlotta Sacerdote; Fredrick Schumacher; Christine Friedenreich; Sara Olson; Veronica Setiawan; Jirong Long; Marta Crous-Bou; Amanda Spurdle; Alison Margaret Dunning; ...
    Publisher: Springer Berlin Heidelberg
    Project: NIH | Epidemiology of Ovarian C... (5R01CA087538-02), NIH | ESTROGEN, DIET, GENETICS ... (5R01CA083918-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Molecular Epidemiology of... (1R01CA105212-01A1), NIH | CALIFORNIA TEACHERS STUDY (5R01CA077398-09), NIH | Genome-Wide Association S... (5R01CA134958-02), NIH | GENES AND THE ESTROGEN EF... (1R01CA091019-01A1), NIH | GENETIC SUSCEPTIBILITY TO... (5R01CA082838-04), NIH | MOLECULAR EPIDEMIOLOGIC S... (1R01CA090899-01), NHMRC | Molecular Epidemiology of... (339435),...

    Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women. Women with a family history of EC have an increased risk for the disease, suggestin...

  • publication . Preprint . Other literature type . Article . 2019
    Open Access English
    Authors:
    Gareth Evans; Marco Montagna; William Newman; Paolo Peterlongo;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | SURVEILLANCE EPIDEMIOLOGY... (N01CN025403-000), NIH | CANCER CENTER SUPPORT GRA... (3P30CA051008-16S1), NIH | Fine-mapping of 8q24 and ... (5R01CA132839-03), EC | IHCAP (310018), NIH | NRG ONCOLOGY NETWORK GROU... (3U10CA180868-02S2), AKA | Finnish Centre of Excelle... (251314), NIH | SPORE in Breast Cancer (5P50CA058223-12), NIH | The Mitochondrial Genome ... (5R01CA149429-05), NHMRC | Epidemiology of Chronic D... (209057), NIH | MOUSE GENETICS (2P30CA008748-43),...

    Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype1,2,3. To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carrier...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Figlioli, Gisella; Bogliolo, Massimo; Catucci, Irene; Caleca, Laura; Lasheras, Sandra Viz; Pujol, Roser; Kiiski, Johanna I; Muranen, Taru A; Barnes, Daniel; Dennis, Joe; ...
    Publisher: HAL CCSD
    Project: EC | BIORISE (669026), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Center Support Gra... (3P30CA068485-21S4), NIH | Genetic Susceptibility An... (1Z01ES049033-10), NIH | Understanding Ethnic Diff... (5U01CA164973-04), NHMRC | Epidemiology of Chronic D... (209057), NIH | Automated Density Measure... (5R01CA177150-03), NIH | Risk and penetrance of mu... (5R01CA192393-02), NIH | Innovative Infrastructure... (5U01CA199277-02), EC | EUROFANCOLEN (305421),...

    Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a br...

  • publication . Article . 2015
    Open Access English
    Authors:
    Jolanta Lissowska; Giske Ursin; Christine Friedenreich; Fredrick Schumacher; Sara Olson; Veronica Setiawan; Peter Kraft;
    Publisher: Public Library of Science
    Project: NIH | Epidemiology of Ovarian C... (5R01CA087538-02), NIH | ENDOMETRIAL CANCER AND PO... (1R01CA075977-01), NIH | A Whole Genome Admixture ... (3R01CA063464-09S1), NIH | Role of Genetic and Lifes... (1R01CA098346-01A1), NIH | CALIFORNIA TEACHERS STUDY (5R01CA077398-09), NIH | Genome-Wide Association S... (5R01CA134958-02), NIH | ESTROGEN, DIET, GENETICS ... (5R01CA083918-04), NIH | BREAST CANCER AND THE BIR... (N01HD023166-008), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01CN067009-004), NIH | GENES AND THE ESTROGEN EF... (1R01CA091019-01A1),...

    Genome-wide association studies (GWAS) have identified common variants that predispose individuals to a higher body mass index (BMI), an independent risk factor for endometrial cancer. Composite genotype risk scores (GRS) based on the joint effect of published BMI risk ...

  • publication . Article . 2016
    Open Access English
    Authors:
    Michael Hoffmeister; Richard Hayes; Bette Caan; Fredrick Schumacher; Tabitha Harrison; Stephanie Bien; Sébastien KÜRY; Mark Jenkins; Hermann Brenner;
    Publisher: Public Library of Science
    Project: NIH | Cancer Prevention Trainin... (5R25CA094880-12), NIH | Hormones and Colon Cancer... (5R01CA076366-07), NIH | Ontario Registry for Stud... (3U01CA074783-09S2), NIH | Cancer Epidemiology Cohor... (5UM1CA167552-02), NIH | A Whole Genome Admixture ... (3R01CA063464-09S1), NIH | EPIDEMIOLOGIC STUDIES OF ... (5P01CA033619-05), NIH | DIET, HORMONES AND RISK O... (3P01CA087969-03S1), NIH | AROMATIC AMINES AND COLON... (5R01CA060987-03), NIH | NUTRITIONAL AND BIOCHEMIC... (5R01CA042182-09), NIH | AUSTRALASIAN COLORECTAL C... (5U01CA097735-05),...

    Genome-wide association studies (GWAS) have identified many common single nucleotide polymorphisms (SNPs) associated with colorectal cancer risk. These SNPs may tag correlated variants with biological importance. Fine-mapping around GWAS loci can facilitate detection of...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Jiang, Xia; Finucane, Hilary K; Schumacher, Fredrick R; Schmit, Stephanie L; Tyrer, Jonathan; Han, Younghun; Michailidou, Kyriaki; Lesseur, Corina; Kuchenbaecker, Karoline B; Dennis, Joe; ...
    Publisher: Nature Publishing Group
    Project: NIH | The Vanderbilt Institute ... (6UL1TR000445-11), NIH | Discovery and verificatio... (5R01CA189184-04), NHMRC | Markers of androgen actio... (450104), NIH | The Mitochondrial Genome ... (5R01CA149429-05), NIH | Cancer Risk Reduction and... (2R37CA070867-12), NIH | Genes contributing for ni... (5R01DA017932-07), NIH | Consortium Study to Ident... (5R01CA148667-05), NIH | Career Development (Ingle... (5P50CA116201-08), NIH | Breast &prostate cancer &... (1U01CA098216-01), NIH | Characterizing Genetic Su... (5U01CA098710-06),...

    Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of Europ...

  • publication . Article . 2017
    Open Access English
    Authors:
    Colin B Begg; Megan S Rice; Emily C Zabor; Shelley S Tworoger;
    Publisher: Nature Publishing Group
    Project: NIH | Statistical Strategies fo... (5R01CA163251-03), NIH | DIET, HORMONES AND RISK O... (3P01CA087969-03S1), NIH | MOUSE GENETICS (2P30CA008748-43)

    Background: The somatic molecular profiles of basal-like breast cancers and high-grade serous ovarian cancers share many similarities, leading to the hypothesis that they have similar aetiologies, in which case they should occur together in the same patient more often t...

13 research outcomes, page 1 of 2
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