- publication . Other literature type . Article . 2019Open AccessAuthors:Jordi Rodon; Heiko Maacke; Martijn P. Lolkema; Mike Thomas; Joe Stephenson; Aditya Bardia; Martin Schuler; Mrinal M. Gounder; Cristiana Sessa; Yongjian Sun; ...pmc: PMC6964137pmid: 31395751Publisher: Alphamed PressProject: NIH | MOUSE GENETICS (2P30CA008748-43)
Abstract Background This multicenter, open‐label, phase Ib study investigated the safety and efficacy of binimetinib (MEK inhibitor) in combination with buparlisib (phosphatidylinositol 3‐kinase [PI3K] inhibitor) in patients with advanced solid tumors with RAS/RAF alter...
- publication . Article . Other literature type . 2019Open AccessAuthors:D. Tregnago; Sara Pilotto; Giulia Sartori; Massimo Lanza; I. Trestini; Miriam Casali; A. Gkountakos; Michele Milella; Lee W. Jones; Lee W. Jones; ...pmc: PMC7066706pmid: 32162811Publisher: WileyProject: NIH | MOUSE GENETICS (2P30CA008748-43)
Abstract Lung cancer remains the leading cause of cancer‐related death worldwide. Affected patients frequently experience debilitating disease‐related symptoms, including dyspnea, cough, fatigue, anxiety, depression, insomnia, and pain, despite the progresses achieved i...
- publication . Article . 2019Open AccessAuthors:Colin Hessel; Michael J. Morris; Joel Picus; Darren R. Feldman; Daniel J. George; Toni K. Choueiri; Susan Halabi; Christian Scheffold; Shaker R. Dakhil; Olwen Hahn; ...pmc: PMC6853096pmid: 31399500Publisher: WileyProject: NIH | Network Lead Academic Par... (3U10CA180791-04S1), NIH | Washington University/ Si... (5U10CA180833-05), NIH | OSU as Network Lead Acade... (1U10CA180850-01), NIH | Statistics and Data Cente... (5U10CA180882-02), NIH | Alliance for Clinical Tri... (3U10CA180821-02S2), NIH | NCI National Clinical Tri... (5U10CA180857-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | NCTN Lead Academic Partic... (5U10CA180867-04)
Abstract Cabozantinib treatment prolonged progression‐free survival (PFS) and improved objective response rate (ORR) compared with sunitinib in patients with advanced renal cell carcinoma (RCC) of intermediate or poor risk by International Metastatic Renal Cell Carcinom...
- publication . Article . Other literature type . 2019Open Access EnglishAuthors:Daly Avendano; Maria Adele Marino; Pedro Zapata; Christopher C. Riedl; Katja Pinker; Katja Pinker;pmc: PMC7011661pmid: 32043792Publisher: John Wiley & Sons, Inc.Project: NIH | MOUSE GENETICS (2P30CA008748-43)
This review provides a comprehensive overview of the available imaging modalities for lymph node assessment in patients diagnosed with primary breast cancer.
- publication . Review . Article . Other literature type . 2016Open Access EnglishAuthors:Aminah Jatoi; Mario E. Lacouture; Patrizia Racca; Yoshimitsu Kobayashi; Janja Ocvirk; Ralf Hofheinz; Jun Zhang; Yoshito Komatsu; Silke Guenther; Gaël Deplanque;pmid: 27449521pmc: PMC5153350Project: NIH | MOUSE GENETICS (2P30CA008748-43)
Skin reactions are the most common adverse events attributable to epidermal growth factor receptor (EGFR) inhibitors. This review leads to the recommendation of prophylactic—rather than reactive—management of skin reactions for all patients receiving EGFR inhibitors bec...
- publication . Other literature type . Article . 2018Open AccessAuthors:Hae Kwang Lee; Yeon Hee Park; Juhee Cho; Jeong Eon Lee; Danbee Kang; Danbee Kang; Young Hyuck Im; Eun Kyung Choi; Eliseo Guallar; Eliseo Guallar; ...pmc: PMC6519756pmid: 30120165Publisher: Alphamed PressProject: NIH | MOUSE GENETICS (2P30CA008748-43)
Chemotherapy‐induced alopecia is (CIA) considered temporary; however, some patients report persistent alopecia several years after chemotherapy. Long‐term prospective data on the incidence and impact of permanent CIA is scarce. This article reports the results of a stud...
- publication . Article . 2018Open Access EnglishAuthors:M. Sitiki Copur; Craig A. Bunnell; Hyman B. Muss; Arti Hurria; Jennifer Le-Rademacher; Gretchen Kimmick; Bhuvaneswari Ramaswamy; Harvey J. Cohen; Stuart M. Lichtman; Myra F. Barginear; ...pmc: PMC6516126pmid: 30409792Publisher: John Wiley & Sons, Inc.Project: NIH | OSU as Network Lead Acade... (1U10CA180850-01), NIH | Delaware/Christiana Care ... (5UG1CA189819-05), NIH | NCI National Clinical Tri... (5U10CA180857-02), NIH | Naional Cancer Institute,... (5U10CA180790-03), NIH | Alliance NCORP Research B... (5UG1CA189823-04), NIH | Network Lead Academic Par... (3U10CA180791-04S1), NIH | North Shore-LIJ Health Sy... (5UG1CA189850-05), NIH | NCTN Lead Academic Partic... (5U10CA180867-04), NIH | NCTN Lead Academic Partic... (5U10CA180838-05), NIH | MOUSE GENETICS (2P30CA008748-43)
Abstract Purpose. A few previous studies report a direct relationship between older age and chemotherapy‐induced neuropathy. This study further evaluated this adverse event's age‐based risk. Methods. CALGB 40101 investigated adjuvant paclitaxel (80 mg/m2 once per week o...
- publication . Other literature type . Article . 2016Open AccessAuthors:Anthony F. Yu; Martin Fleisher; Sujata Patil; Shawn C. Pun; Clifford A. Hudis; Chau T. Dang; Carlos R. Manrique; Jennifer E. Liu; Richard M. Steingart; Elton Mara; ...pmc: PMC4828117pmid: 26984450Publisher: Alphamed PressProject: NIH | MOUSE GENETICS (2P30CA008748-43)
Introduction. Myocardial strain imaging and blood biomarkers have been proposed as adjuncts to left ventricular ejection fraction (LVEF) monitoring for the early detection of cardiotoxicity during cancer therapy. We report the results of a preplanned cardiac safety anal...
- publication . Article . Other literature type . 2016Open AccessAuthors:Jonas Sokolof; Kate Fife; Rainer Kunstfeld; Rogerio I. Neves; Reinhard Dummer; Aleksandar Sekulic; Scott Ernst; Ketty Peris; Axel Hauschild; Nicole Basset-Seguin; ...Publisher: WileyProject: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Genetic Epidermiology of ... (1R01CA083115-01A2)
Vismodegib and sonidegib are Hedgehog pathway inhibitors (HPIs) approved for treatment of patients with advanced basal cell carcinoma. The adverse events (AEs) associated with these therapies can impact clinical outcomes as a result of decreased quality of life and trea...
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