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6 research outcomes, page 1 of 1
  • publication . Article . 2019
    Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association.
    Open Access English
    Authors:
    Gini F. Fleming; B.D. Green; Kyle Hernandez; Kathleen R. Bowie; Caroline R. Kim; Mayra A. Betancourt-Ponce; Eva Tonsing-Carter; Ryan V. Harkless; Sarat Chandarlapaty; Diana C. West-Szymanski; ...
    doi: 10.1186/s13058-019-1164-6
    pmc: PMC6651939
    pmid: 31340854
    Publisher: BMC
    Project: NIH | Investigate the role of T... (1R01CA196648-01A1), NIH | Therapeutic approaches to... (1R01CA204999-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Glucocorticoid receptor-m... (5R01CA089208-08), NIH | Cancer Center Support Gra... (3P30CA014599-36S1)

    Background Non-ER nuclear receptor activity can alter estrogen receptor (ER) chromatin association and resultant ER-mediated transcription. Consistent with GR modulation of ER activity, high tumor glucocorticoid receptor (GR) expression correlates with improved relapse-...

  • publication . Article . Other literature type . 2016
    Clonal relationships between lobular carcinoma in situ and other breast malignancies
    Open Access
    Authors:
    Michail Schizas; Dilip Giri; Colin B. Begg; Venkatraman E. Seshan; Victor P. Andrade; Tari A. King; Audrey Mauguen; Irina Ostrovnaya; Russell Towers; Rita A. Sakr; ...
    doi: 10.1186/s13058-016-0727-z
    pmc: PMC4918003
    pmid: 27334989
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Statistical Strategies fo... (5R01CA163251-03)

    Background Recent evidence suggests that lobular carcinoma in situ (LCIS) can be a clonal precursor of invasive breast cancers of both the ductal and lobular phenotypes. We sought to confirm these findings with an extensive study of fresh frozen breast specimens from wo...

  • publication . Article . Other literature type . 2019
    Limited role of DWI with apparent diffusion coefficient mapping in breast lesions presenting as non-mass enhancement on dynamic contrast-enhanced MRI.
    Open Access English
    Authors:
    Daly Avendano; Daly Avendano; Pascal A. T. Baltzer; Katja Pinker; Katja Pinker; Doris Leithner; Danny F. Martinez; Paola Clauser; Panagiotis Kapetas; Sunitha B. Thakur; ...
    doi: 10.1186/s13058-019-1208-y
    pmc: PMC6894318
    pmid: 31801635
    Publisher: BioMed Central
    Project: EC | MURAB (688188), NIH | MOUSE GENETICS (2P30CA008748-43), EC | CANCER SCAN (828978), EC | HYPMED (667211)

    <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Available data proving the value of DWI for breast cancer diagnosis is mainly for enhancing masses; DWI may be less sensitive and specific in non-mass enhancement (NME) lesions. The ...

  • publication . Article . 2016
    Systemic therapy for breast cancer and risk of subsequent contralateral breast cancer in the WECARE Study
    Open Access
    Authors:
    Esther M. John; Esther M. John; Leslie Bernstein; Lene Mellemkjær; Jonine L. Bernstein; Patrick Concannon; Meghan Woods; Kathleen E. Malone; Anne S. Reiner; Rikke Langballe; ...
    doi: 10.1186/s13058-016-0726-0
    pmc: PMC4940926
    pmid: 27400983
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Breast Cancer, Radiation ... (5R01CA114236-02), NIH | BREAST CANCER, RADIATION ... (5U01CA083178-02), NIH | Interaction of Radiation,... (5R01CA097397-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Genome-Wide Association S... (5R01CA129639-05)

    Background Treatment with tamoxifen or chemotherapy reduces the risk of contralateral breast cancer (CBC). However, it is uncertain how long the protection lasts and whether the protective effect is modified by patient, tumor, or treatment characteristics. Methods The p...

  • publication . Article . Other literature type . 2019
    Radiomic signatures with contrast-enhanced magnetic resonance imaging for the assessment of breast cancer receptor status and molecular subtypes: initial results.
    Open Access English
    Authors:
    Blanca Bernard-Davila; Maxine S. Jochelson; Danny F. Martinez; Joao V. Horvat; Katja Pinker; Elizabeth A. Morris; Sunitha B. Thakur; Maria Adele Marino; Maria Adele Marino; Doris Leithner; ...
    doi: 10.1186/s13058-019-1187-z
    pmc: PMC6739929
    pmid: 31514736
    Publisher: BioMed Central
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), EC | HYPMED (667211)

    <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>To evaluate the diagnostic performance of radiomic signatures extracted from contrast-enhanced magnetic resonance imaging (CE-MRI) for the assessment of breast cancer receptor statu...

  • publication . Article . 2010
    Differential interleukin-6/Stat3 signaling as a function of cellular context mediates Ras-induced transformation
    Open Access English
    Authors:
    Katrina Podsypanina; Kenneth Leslie; Hao Ho; Lionel B. Ivashkiv; Marjan Berishaj; Jacqueline Bromberg; Sizhi P. Gao;
    doi: 10.1186/bcr2725
    pmc: PMC3096973
    pmid: 20929542
    Publisher: Springer Nature
    Project: NIH | Role of Stat3 in Breast C... (5R01CA087637-03), NIH | MOUSE GENETICS (2P30CA008748-43)

    Introduction Tyrosine phosphorylated signal transducer and activator of transcription 3 (pStat3) is expressed in numerous cancers and is required for mediating tumorigenesis. Autocrine and paracrine interleukin (IL)-6 signaling is the principal mechanism by which Stat3 ...

6 research outcomes, page 1 of 1