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1,223 research outcomes, page 1 of 123
  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Jason Lewis; Nerissa Viola; Linden Wyatt; Mirkka P Sarparanta;
    Publisher: American Chemical Society (ACS)
    Project: NIH | pHLIP-based agents for pr... (1F32CA186721-01A1), NIH | Shared Instrument: Focus ... (1S10RR020892-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | PET Imaging of Cancer wit... (5R01CA138468-04), NIH | The Ivis Spectrum CT for ... (1S10OD016207-01), AKA | New radiolabeled molecula... (278056)

    pH (low) insertion peptides (pHLIP peptides) target acidic extracellular environments in vivo due to pH-dependent cellular membrane insertion. Two variants (Var3 and Var7) and wild-type (WT) pHLIP peptides have shown promise for in vivo imaging of breast cancer. Two pos...

  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Li, Qiongge; Ferraro, Gino Del; Pasquini, Luca; Peck, Kyung K.; Makse, Hernán A.; Holodny, Andrei I.;
    Publisher: MIT Press
    Project: NIH | Developmental Core (5U54CA132378-03), NIH | MOUSE GENETICS (2P30CA008748-43), NSF | CRCNS: Targeted Stimulati... (1515022), NIH | Planning and Evaluation (5U54CA137788-03), NIH | Supplement: Network Metho... (3R01EB022720-03S1)

    Functional magnetic resonance imaging (fMRI) is widely used in clinical applications to highlight brain areas involved in specific cognitive processes. Brain impairments, such as tumors, suppress the fMRI activation of the anatomical areas they invade and, thus, brain-d...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Murray, Katie S.; Liu, Nick W.; Russo, Paul;
    Publisher: Elsevier
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)
  • publication . Article . 2017
    Open Access
    Authors:
    Remus, Barbara S.; Goldgur, Yehuda; Shuman, Stewart;
    Publisher: Oxford University Press (OUP)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | VACCINIA VIRUS MRNA TRANS... (2R01GM042498-10), NIH | NE-CAT Center for Advance... (4P41GM103403-14)

    Abstract Fungal tRNA ligase (Trl1) is an essential enzyme that repairs RNA breaks with 2′,3′-cyclic-PO4 and 5′-OH ends inflicted during tRNA splicing and non-canonical mRNA splicing in the fungal unfolded protein response. Trl1 is composed of C-terminal cyclic phosphodi...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Shuji Ogino; Brendan Guercio; Donna Niedzwiecki;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Multidisciplinary Trainin... (5T32HL125232-02), NIH | NCTN Lead Academic Partic... (5U10CA180867-04), NIH | Alliance for Clinical Tri... (3U10CA180821-02S2), NIH | Network Lead Academic Par... (3U10CA180791-04S1), NIH | Accelerating Transdiscipl... (5R35CA197735-04), NIH | Statistics and Data Cente... (5U10CA180882-02), NIH | CANCER AND LEUKEMIA GROUP... (5U10CA060138-04), NIH | Southeast Clinical Oncolo... (5UG1CA189858-02), NIH | Role of Vitamin D, Inflam... (5K07CA148894-02), NIH | ECOG-ACRIN Operations Cen... (3U10CA180820-02S3),...

    Purpose Observational studies have demonstrated increased colon cancer recurrence and mortality in states of excess energy balance, as denoted by factors including sedentary lifestyle, diabetes, increased dietary glycemic load, and increased intake of sugar-sweetened be...

  • publication . Article . 2017
    Open Access English
    Authors:
    Joseph Kanik;
    Publisher: Elsevier
    Project: NIH | Clinical and Translationa... (3UL1RR024996-03S2), NIH | STUDY OF EXPOSURES, BEHAV... (5R01CA137420-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Study of exposures and bi... (5R01CA197402-02)

    The data presented in this article are related to the research article entitled “Measuring differential treatment benefit across marker specific subgroups: the choice of outcome scale” (Satagopan and Iasonos, 2015) [1]. These data were digitally reconstructed from figur...

  • publication . Article . 2016
    Open Access
    Authors:
    Vickers, Andrew J.;
    Publisher: Springer Science and Business Media LLC
    Project: WT , NIH | MOUSE GENETICS (2P30CA008748-43), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    Ten years ago, one of the first papers published in Trials was a commentary entitled “Whose data set is it anyway?” The commentary pointed out that trialists routinely refused requests for data sharing and argued that this attitude was a community standard that had no r...

  • publication . Article . 2017
    Open Access
    Authors:
    Nori, Priya; Madaline, Theresa; Munjal, Iona; Bhar, Shubha; Guo, Yi; Seo, Susan K.; Porrovecchio, Andrea; Gancher, Elizabeth; Nosanchuk, Joshua; Pirofski, Liise-anne; ...
    Publisher: Oxford University Press (OUP)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>To impart principles of antimicrobial stewardship (AS) and infection prevention and control (IPC), we developed a curriculum tailored to the diverse aptitudes of learners at our med...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Professor Rosalind Eeles; Nicola Nicolai; Elizabeth Bancroft; Marta Cardoso; Lidia Feliubadalo; Manuel R. Teixeira; Gareth Evans; Judith Offman;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    Background: Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-antigen (PSA) in men with germline BRCA1/2 mutations. Objective: To report the utility of ...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Jessica Vincent; Carolina Adura; Pu Gao; Antonio Luz; Lodoe Lama; Yasutomi Asano; Rei Okamoto; Toshihiro Imaeda; Jumpei Aida; Katherine Rothamel; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Posttranscriptional regul... (5R01GM104962-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Chemistry Biology Interfa... (4T32GM065086-14), NIH | Deciphering Post-transcri... (1R35GM119569-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14)

    Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflammatory genes. Here the authors develop small molecule cGAS inhibitors, functionally characterize them and present the inhibitor and DNA bound cGAS cr...

1,223 research outcomes, page 1 of 123
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