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738 research outcomes, page 1 of 74
  • publication . Article . 2017
    Open Access English
    Authors:
    Yingxia Liu; Ziad Saleh; Yulin Song; Maria Chan; Xiang Li; Chengyu Shi; Xin Qian; Xiaoli Tang;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Segmentation of prostate Cone Beam CT (CBCT) images is an essential step towards real-time adaptive radiotherapy (ART). It is challenging for Calypso patients, as more artifacts generated by the beacon transponders are present on the images. We herein propose a novel wa...

  • publication . Article . 2017
    Open Access
    Authors:
    Olujide Arije;
    Publisher: American Society of Clinical Oncology (ASCO)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    <jats:sec><jats:title>Purpose</jats:title><jats:p> In low- and middle-income countries like Nigeria, women present with advanced breast cancer at an earlier age. Given the limited resources, development of screening programs that parallel resource capabilities of low- a...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Robert J. Motzer; Bernard Escudier; Thomas Powles; Christian Scheffold; Toni K. Choueiri;
    Publisher: Nature Publishing Group UK
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Background In the phase 3 METEOR trial (NCT01865747), cabozantinib significantly improved progression-free survival, overall survival, and objective response rate compared with everolimus in patients with advanced renal cell carcinoma (RCC) after prior antiangiogenic th...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Shan Tan; Clovis Tauber; Dimitris VISVIKIS; Vincent Jaouen;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Quantitative PET/CT Analy... (4R01CA172638-04)

    Abstract Introduction Automatic functional volume segmentation in PET images is a challenge that has been addressed using a large array of methods. A major limitation for the field has been the lack of a benchmark dataset that would allow direct comparison of the result...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Sanford Simon; David Requena;
    Publisher: Proceedings of the National Academy of Sciences
    Project: NIH | Cellular Pathogenesis of ... (5R56CA207929-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Intratumoral Heterogeneit... (5F31CA192835-03)

    <jats:p>A segmental deletion resulting in <jats:italic>DNAJB1–PRKACA</jats:italic> gene fusion is now recognized as the signature genetic event of fibrolamellar hepatocellular carcinoma (FL-HCC), a rare but lethal liver cancer that primarily affects adolescents and youn...

  • publication . Preprint . Other literature type . Article . 2019
    Open Access
    Authors:
    Elham Ahmadzadeh; N. Sumru Bayin; Xinli Qu; Aditi Singh; Linda Madisen; Daniel Stephen; Hongkui Zeng; Alexandra L. Joyner; Alberto Rosello-Diez;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Signaling pathways that r... (1R01NS092096-01), NIH | A novel genetic approach ... (5R21HD083860-02)

    <jats:title>Abstract</jats:title><jats:p>Thanks to many advances in genetic manipulation, mouse models have become very powerful in their ability to interrogate biological processes. In order to precisely target expression of a gene of interest to particular cell types,...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Shen, Ronglai; Seshan, Venkatraman E.;
    Publisher: Oxford University Press (OUP)
    Project: NIH | Statistical Strategies fo... (5R01CA163251-03), NIH | Defining a novel subtype ... (1R21CA195365-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms and Modulators... (5P01CA129243-07)

    Allele-specific copy number analysis (ASCN) from next generation sequencing (NGS) data can greatly extend the utility of NGS beyond the identification of mutations to precisely annotate the genome for the detection of homozygous/heterozygous deletions, copy-neutral loss...

  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Gutridge, Anna M.; Robins, Meridith T.; Cassell, Robert J.; Uprety, Rajendra; Mores, Kendall L.; Ko, Mee Jung; Pasternak, Gavril W.; Majumdar, Susruta; Rijn, Richard M.;
    Publisher: John Wiley and Sons Inc.
    Project: NIH | Development of G-protein ... (1R03DA045897-01), NIH | The influence of alcohol ... (1R21AA026675-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | G-protein-, beta-arrestin... (1R01AA025368-01A1), NIH | Chemistry and Biology of ... (1R01DA046487-01), NIH | Pharmacological Probes ba... (1R21DA045884-01), NIH | Synthesis and pharmacolog... (5R01DA006241-27), NIH | Opioidergic alkaloids fro... (1R21AA026949-01), NIH | Behavioral Pharmacology o... (2T32DA007242-26)

    Background and Purpose Mitragyna speciosa, more commonly known as kratom, is a plant that contains opioidergic alkaloids but is unregulated in most countries. Kratom is used in the self‐medication of chronic pain and to reduce illicit and prescription opioid dependence....

  • publication . Preprint . Article . Other literature type . 2016
    Open Access English
    Authors:
    Anton Henssen; Richard Koche; Luca Pinello;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Discovering disease-causa... (5K99HG008399-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Epigenetic regulation of ... (4K08DK093705-05), NIH | Aberrant activation of HG... (5K08CA160660-02)

    <jats:title>Abstract</jats:title><jats:p><jats:bold>Background.</jats:bold> Numerous human genes encode potentially active DNA transposases or recombinases, but our understanding of their functions remains limited due to shortage of methods to profile their activities o...

  • publication . Article . 2018
    Open Access English
    Authors:
    Ann Abraham; Rosa Ahn; Alexandra Woodbridge; Erin Madden; Salomeh Keyhani; Deborah Korenstein;
    Publisher: Springer US
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | An Evaluation of Novel Do... (1R01HL116522-01A1), NIH | Comparative Effectiveness... (5R01HL114563-02)
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