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818 research outcomes, page 1 of 82
  • publication . Article . 2017
    Open Access English
    Authors:
    Cho, Christina; Hsu, Meier; Barba, Pere; Maloy, Molly A.; Avecilla, Scott T.; Barker, Juliet N.; Castro-Malaspina, Hugo; Giralt, Sergio A.; Jakubowski, Ann A.; Koehne, Guenther; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14)

    Altres ajuts: This research was supported in part by National Institutes of Health award number P01 CA23766 and NIH/NCI Cancer Center Support Grant P30 CA008748. The content is solely the responsibility of the authors and does not necessarily represent the official view...

  • publication . Other literature type . Article . 2014
    Open Access
    Authors:
    Peter Lewis; Lisa Sullivan;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Unraveling glutamine meta... (5K08CA181475-05), NIH | Role of IDH Mutations in ... (1R01CA168802-01A1), NIH | MOUSE GENETICS (2P30CA008748-43)

    Pediatric glioblastomas (GBM) are highly aggressive and lethal tumors. Recent sequencing studies have shown that ~30 % of pediatric GBM and ~80 % of diffuse intrinsic pontine gliomas show K27M mutations in the H3F3A gene, a variant encoding histone H3.3. H3F3A K27M muta...

  • publication . Article . 2015
    Open Access
    Authors:
    Robert Soslow; Jennifer Mueller;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Small cell carcinoma of the ovary, hypercalcemic type is an aggressive tumor generally affecting young women with limited treatment options. Mutations in SMARCA4, a catalytic subunit of the SWI/SNF chromatin remodeling complex, have recently been identified in nearly al...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Melody Smith;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Stem cell transplantation (SCT), an effective therapy for amyloid light chain (AL) amyloidosis patients, is associated with low treatment-related mortality (TRM) with appropriate patient selection and risk-adapted dosing of melphalan (RA-SCT). Consolidation after SCT in...

  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Yaohua Xue; Luciano Martelotto; Timour Baslan; Alberto Vides; Martha Solomon; Trang Thi Mai; Neelam Chaudhary; Greg J Riely; Bob T Li; Kerry Scott; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Elucidating the regulatio... (5K08CA191082-02)

    The principles governing evolution of tumors exposed to targeted therapy are poorly understood. Here we modeled the selection and propagation of BRAF amplification (BRAFamp) in patient-derived tumor xenografts (PDX) treated with a direct ERK inhibitor, alone or in combi...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Audrey Mauguen;
    Publisher: Springer Nature
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Statistical Strategies fo... (5R01CA163251-03)

    Background Recent evidence suggests that lobular carcinoma in situ (LCIS) can be a clonal precursor of invasive breast cancers of both the ductal and lobular phenotypes. We sought to confirm these findings with an extensive study of fresh frozen breast specimens from wo...

  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Andrea Ventura; Juan Camilo Correa; Doron Betel;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Background MicroRNAs (miRNAs) are potential biomarkers in various malignancies. We aim to characterize miRNA expression in intrahepatic cholangiocarcinoma (ICC) and identify circulating plasma miRNAs with potential diagnostic and prognostic utility. Methods Using deep-s...

  • publication . Other literature type . Preprint . Article . 2019
    Open Access
    Authors:
    Marcel Hohl; Aditya Mojumdar; Sarem Hailemariam; Vitaly Kuryavyi; Fiorella Ghisays; Kyle Sorenson; Matthew Chang; Barry S. Taylor; Dinshaw J. Patel; Peter M. Burgers; ...
    Publisher: bioRxiv
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | ROLES AND REGULATION OF P... (1P01CA087497-01), NIH | Rad50: Roles in chromo. s... (5R01GM056888-20), NIH | Mechanisms of DNA replica... (5R35GM118129-03), NSERC , CIHR

    Author summary A complex network of functions is required for suppressing tumorigenesis. These include processes that regulate cell growth and differentiation, processes that repair damage to DNA and thereby prevent cancer promoting mutations and signaling pathways that...

  • publication . Article . 2017
    Open Access
    Authors:
    Virmani, Pooja; Busam, Klaus; Myskowski, Patricia L.; Yang, Amy; Magro, Cynthia; Horwitz, Steven;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)
  • publication . Preprint . 2019
    Open Access English
    Authors:
    Tan, Jiaxing; Jing, Longlong; Huo, Yumei; Tian, Yingli; Akin, Oguz;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Lung segmentation in computerized tomography (CT) images is an important procedure in various lung disease diagnosis. Most of the current lung segmentation approaches are performed through a series of procedures with manually empirical parameter adjustments in each step...

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