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6 research outcomes, page 1 of 1
  • publication . Preprint . Research . Other literature type . 2019
    Open Access English
    Authors:
    Pradier, Melanie F.; Hyland, Stephanie L.; Stark, Stefan G.; Lehmann, Kjong; Vogt, Julia E.; Perez-Cruz, Fernando; Rätsch, Gunnar;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), EC | MLPM2012 (316861)

    <jats:title>Abstract</jats:title><jats:sec><jats:title>Motivation</jats:title><jats:p>Personalized medicine aims at combining genetic, clinical, and environmental data to improve medical diagnosis and disease treatment, tailored to each patient. This paper presents a Ba...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Bernhard Reis; Dana Pe'er; Craig Gedye; Vito Riccardo Tomaso Zanotelli; Maries van den Broek;
    Publisher: Elsevier BV
    Project: CIHR , NHMRC | Characterization of Ovari... (628939), NIH | MOUSE GENETICS (2P30CA008748-43), EC | LTFCOFUND2013 (609409), NIH | Integrative Cancer Genomi... (5R01CA164729-03), EC | SIGNALING 3D (336921), NIH | Single cell mapping of de... (7DP1HD084071-04)

    Applying mass cytometry for high-dimensional single-cell analysis depicts an in-depth atlas of the immune microenvironment in clear cell renal cell carcinoma patients, thereby linking immune compositions with clinical features.

  • publication . Other literature type . Article . 2018 . Embargo End Date: 09 Jan 2019
    Open Access
    Authors:
    Cline, Melissa S; Liao, Rachel G; Parsons, Michael T; Paten, Benedict; Alquaddoomi, Faisal; Antoniou, Antonis; Baxter, Samantha; Brody, Larry; Cook-Deegan, Robert; Coffin, Amy; ...
    Publisher: Apollo - University of Cambridge Repository
    Project: NIH | Building the Medical Info... (5R01HG008918-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | EMERGE III CENTRAL SEQUEN... (5U01HG008676-02), NIH | Visualization hub for gen... (5U24CA210974-02), NIH | Cloud Based Resource for ... (5U24CA180951-05), NIH | The Future of PharmGKB Fu... (3U41HG009649-01S1), NHMRC | Research Fellowship – Gen... (1061779), NIH | Global Infrastructure for... (5U24CA210999-03), CIHR , NIH | Center for Big Data in Tr... (3U54HG007990-03S3),...

    The BRCA Challenge is a long-term data-sharing project initiated within the Global Alliance for Genomics and Health (GA4GH) to aggregate BRCA1 and BRCA2 data to support highly collaborative research activities. Its goal is to generate an informed and current understandi...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Kamini Singh; Jianan Lin; Yi Zhong; Antonija Burčul; Prathibha Mohan; Man Jiang; Liping Sun; Vladimir Yong-Gonzalez; Agnes Viale; Justin R. Cross; ...
    Publisher: Rockefeller University Press
    Project: NIH | The genomic pathogenesis ... (5R01CA190384-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Towards The Chemotherapy-... (1R01CA183876-01), NIH | RNA Structurome in Post-T... (5R35GM124998-02), NIH | Exploring oncogenic trans... (5R01CA207217-03)

    Singh et al. show that MYC affects mRNA translation efficiency and start-site selection. Notable examples include the translation of mRNAs encoding most proteins of the electron transport chain and aberrant translation initiation site usage in the CD19 receptor that all...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Yansheng Liu; Holger Alexander Ebhardt;
    Publisher: Springer Science and Business Media LLC
    Project: EC | PrECISE (668858), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Pathway Commons: Research... (5U41HG006623-06), EC | PROTEOMICS4D (670821), NIH | Core_Training (2P41GM103504-06)

    Author summary Metastatic prostate cancer is often treated with pharmacological agents to prevent the tumor from expanding; however, despite advances in drug development patients often die of the disease. An international research team lead by Ruedi Aebersold (ETH Züric...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Andreas Prlic; Gustavo Glusman; Michael A Hicks; Peter Rose; Jianjiong Gao;
    Publisher: eScholarship, University of California
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Biomedical Data Translato... (3OT3TR002026-01S2)

    The translation of personal genomics to precision medicine depends on the accurate interpretation of the multitude of genetic variants observed for each individual. However, even when genetic variants are predicted to modify a protein, their functional implications may ...

6 research outcomes, page 1 of 1
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