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19 research outcomes, page 1 of 2
  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Elisabeth F. P. Peterse; Reinier G. S. Meester; Rebecca L. Siegel; Jennifer C. Chen; Andrea Dwyer; Dennis J. Ahnen; Robert A. Smith; Ann G. Zauber; Iris Lansdorp-Vogelaar;
    Project: NIH | Comparative Modeling of C... (5U01CA199335-03), NIH | MOUSE GENETICS (2P30CA008748-43)

    BACKGROUND In 2016, the Microsimulation Screening Analysis‐Colon (MISCAN‐Colon) model was used to inform the US Preventive Services Task Force colorectal cancer (CRC) screening guidelines. In this study, 1 of 2 microsimulation analyses to inform the update of the Americ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Shuchi Agrawal Singh; Mads Lerdrup; Ana-Luisa R Gomes; Harmen JG van de Werken; Jens Vilstrup Johansen; Robin Andersson; Albin Sandelin; Kristian Helin; Klaus Hansen;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), WT

    textabstractThe PLZF transcription factor is essential for osteogenic differentiation of hMSCs; however, its regulation and molecular function during this process is not fully understood. Here, we revealed that the ZBTB16 locus encoding PLZF, is repressed by Polycomb (P...

  • publication . Article . 2019
    Open Access English
    Authors:
    Ross L. Levine; Peter J.M. Valk;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Risk-stratification of acute myeloid leukemia (AML) based on recurrent somatic abnormalities has evolved substantially in recent years, as illustrated by the current 2017 European LeukemiaNet (ELN) risk stratification.[1][1] These 2017 ELN AML risk stratification recomm...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    marco zappa; Arnauld VILLERS; Anssi Auvinen;
    Publisher: Wiley
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Modeling prostate cancer ... (5U01CA157224-03), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10), NIH | Prospective validation of... (5R01CA160816-02)

    BACKGROUND: Prostate-specific antigen (PSA) screening and concomitant treatment can be implemented in several ways. The authors investigated how the net benefit of PSA screening varies between common practice versus “good practice.”. METHODS: Microsimulation screening a...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Pascal Guenel; bernard peissel; mikael eriksson; Thilo Dörk; Anna Jakubowska; Anna Marie Mulligan; Paolo Radice; Sara Olson; Peter Kraft; Florian Heitz; ...
    Project: NIH | Long Term Multidisciplina... (5UM1CA186107-05), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Epidemiology Cohor... (5UM1CA167552-02), NHMRC | Translation of PALB2 gene... (1029974), NHMRC | Personalized clinical gen... (1061177), NIH | MHC-Restricted and MHC-No... (1P50CA159981-01A1), NIH | OVARIAN CANCER RISK AND S... (5K07CA080668-06), WT | Understanding the genetic... (090532), NIH | DIET, HORMONES AND RISK O... (3P01CA087969-03S1), EC | COGS (223175),...

    <p style="-webkit-font-smoothing: antialiased; box-sizing: border-box; margin: 0px auto 10px; line-height: 2.5rem;"><strong style="-webkit-font-smoothing: antialiased; box-sizing: border-box;">Background:</strong> The rarity of mutations in <em style="-webkit-font-smoot...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Professor Rosalind Eeles; Nicola Nicolai; Elizabeth Bancroft; Marta Cardoso; Lidia Feliubadalo; Manuel R. Teixeira; Gareth Evans; Judith Offman;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    Background: Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-antigen (PSA) in men with germline BRCA1/2 mutations. Objective: To report the utility of ...

  • publication . Article . 2018
    Open Access English
    Authors:
    Vigdis Stefansdottir; Diana M Eccles; Elena Castro; Professor Rosalind Eeles; Nicola Nicolai; Hans Vasen; Elizabeth Bancroft; Jan Lubinski; Lidia Feliubadalo; Manuel R. Teixeira; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Background: Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis ...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Kim, Jun Hyun; Grosbart, Malgorzata; Anand, Roopesh; Wyman, Claire; Cejka, Petr; Petrini, John H.J.;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Functional analysis of Ch... (1F32GM105296-01)

    Summary: The Mre11 complex (Mre11, Rad50, and Nbs1) is integral to both DNA repair and ataxia telangiectasia mutated (ATM)-dependent DNA damage signaling. All three Mre11 complex components are essential for viability at the cellular and organismal levels. To delineate ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Figlioli, Gisella; Bogliolo, Massimo; Catucci, Irene; Caleca, Laura; Lasheras, Sandra Viz; Pujol, Roser; Kiiski, Johanna I; Muranen, Taru A; Barnes, Daniel; Dennis, Joe; ...
    Publisher: HAL CCSD
    Project: EC | BIORISE (669026), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Center Support Gra... (3P30CA068485-21S4), NIH | Genetic Susceptibility An... (1Z01ES049033-10), NIH | Understanding Ethnic Diff... (5U01CA164973-04), NHMRC | Epidemiology of Chronic D... (209057), NIH | Automated Density Measure... (5R01CA177150-03), NIH | Risk and penetrance of mu... (5R01CA192393-02), NIH | Innovative Infrastructure... (5U01CA199277-02), EC | EUROFANCOLEN (305421),...

    Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a br...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Kubik-Huch, Rahel A.; Vilgrain, Valérie; Krestin, Gabriel P.; Reiser, Maximilian F.; Attenberger, Ulrike I.; Muellner, Ada U.; Hess, Christopher P.; Hricak, Hedvig;
    Publisher: Springer Berlin Heidelberg
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Women in Focus: Be Inspired was a unique programme held at the 2019 European Congress of Radiology that was structured to address a range of topics related to gender and healthcare, including leadership, mentoring and the generational progression of women in medicine. I...

19 research outcomes, page 1 of 2
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