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5 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Marianna Thordardottir; Sigrún Helga Lund; Ebba K Lindqvist;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | AGES STUDY-THE REYKJAVIK ... (N01AG012100-017)

    The AGES-Reykjavik Study was funded by NIH contract N01-AG-012100, the Intramural Research Program of the National Institute on Aging, by the Icelandic Heart Association, and the Icelandic Parliament. This work was supported by the Icelandic Centre for Research, RANNIS ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Professor Rosalind Eeles; Nicola Nicolai; Elizabeth Bancroft; Marta Cardoso; Lidia Feliubadalo; Manuel R. Teixeira; Gareth Evans; Judith Offman;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    Background: Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-antigen (PSA) in men with germline BRCA1/2 mutations. Objective: To report the utility of ...

  • publication . Article . 2018
    Open Access English
    Authors:
    Vigdis Stefansdottir; Diana M Eccles; Elena Castro; Professor Rosalind Eeles; Nicola Nicolai; Hans Vasen; Elizabeth Bancroft; Jan Lubinski; Lidia Feliubadalo; Manuel R. Teixeira; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Background: Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Figlioli, Gisella; Bogliolo, Massimo; Catucci, Irene; Caleca, Laura; Lasheras, Sandra Viz; Pujol, Roser; Kiiski, Johanna I; Muranen, Taru A; Barnes, Daniel; Dennis, Joe; ...
    Publisher: HAL CCSD
    Project: EC | BIORISE (669026), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Center Support Gra... (3P30CA068485-21S4), NIH | Genetic Susceptibility An... (1Z01ES049033-10), NIH | Understanding Ethnic Diff... (5U01CA164973-04), NHMRC | Epidemiology of Chronic D... (209057), NIH | Automated Density Measure... (5R01CA177150-03), NIH | Risk and penetrance of mu... (5R01CA192393-02), NIH | Innovative Infrastructure... (5U01CA199277-02), EC | EUROFANCOLEN (305421),...

    Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a br...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Jiang, Xia; Finucane, Hilary K; Schumacher, Fredrick R; Schmit, Stephanie L; Tyrer, Jonathan; Han, Younghun; Michailidou, Kyriaki; Lesseur, Corina; Kuchenbaecker, Karoline B; Dennis, Joe; ...
    Publisher: Nature Publishing Group
    Project: NIH | The Vanderbilt Institute ... (6UL1TR000445-11), NIH | Discovery and verificatio... (5R01CA189184-04), NHMRC | Markers of androgen actio... (450104), NIH | The Mitochondrial Genome ... (5R01CA149429-05), NIH | Cancer Risk Reduction and... (2R37CA070867-12), NIH | Genes contributing for ni... (5R01DA017932-07), NIH | Consortium Study to Ident... (5R01CA148667-05), NIH | Career Development (Ingle... (5P50CA116201-08), NIH | Breast &prostate cancer &... (1U01CA098216-01), NIH | Characterizing Genetic Su... (5U01CA098710-06),...

    Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of Europ...

5 research outcomes, page 1 of 1
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