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3 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2020
    Open Access
    León‐Castillo, Alicia; Gilvazquez, Ester; Nout, Remi; Smit, Vincent THBM; McAlpine, Jessica N; McConechy, Melissa; Kommoss, Stefan; Brucker, Sara Y; Carlson, Joseph W; Epstein, Elisabeth; ...
    Publisher: Wiley
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Endometrial carcinoma (EC) molecular classification based on four molecular subclasses identified in The Cancer Genome Atlas (TCGA) has gained relevance in recent years due to its prognostic utility and potential to predict benefit from adjuvant treatment. While most EC...

  • publication . Other literature type . Article . 2016 . Embargo End Date: 24 Aug 2016
    Open Access English
    Iratxe Macias; Leire Arreal; Charles Lawrie; roger gomis; Violeta Serra; Maria Vivanco; Marco Piva; Giacomo Domenici; Ana Rosa Cortazar; Patricia Zúñiga García; ...
    Publisher: Apollo - University of Cambridge Repository
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), EC | CANCERMETAB (336343)

    Patient stratification has been instrumental for the success of targeted therapies in breast cancer. However, the molecular basis of metastatic breast cancer and its therapeutic vulnerabilities remain poorly understood. Here we show that PML is a novel target in aggress...

  • publication . Article . Other literature type . 2019
    Open Access English
    Francesco Maura; Andrea Degasperi; Ferran Nadeu; Daniel Leongamornlert; Helen Davies; Luiza Moore; Romina Royo; Bachisio Ziccheddu; Xose S. Puente; Herve Avet-Loiseau; ...
    Publisher: Nature Publishing Group
    Project: WT , NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Career Development Progra... (5P50CA100707-13), NIH | MOLECULAR MANIPULATION TO... (5I01BX001584-04), EC | bECOMiNG (817997)

    Analysis of mutational signatures is becoming routine in cancer genomics, with implications for pathogenesis, classification, prognosis, and even treatment decisions. However, the field lacks a consensus on analysis and result interpretation. Using whole-genome sequenci...

3 research outcomes, page 1 of 1
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