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28 research outcomes, page 1 of 3
  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Amos, CI; Dennis, Joe; Wang, Z; Byun, J; Schumacher, FR; Gayther, SA; Casey, G; Hunter, DJ; Sellers, TA; Gruber, SB; ...
    Publisher: American Association for Cancer Research
    Project: NIH | MOLECULAR EPIDEMIOLOGY OF... (5R01CA081488-05), NIH | Discovery Expansion and R... (5U19CA148065-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Career Development (Ingle... (5P50CA116201-08), NIH | Breast Cancer Family Regi... (1UM1CA164920-01A1), NIH | Mayo Clinic SPORE in Ovar... (3P50CA136393-05S1), NIH | Follow-up of Ovarian Canc... (3U19CA148112-04S1), NIH | Mayo Comprehensive Cancer... (3P30CA015083-37S2), EC | RADIOGENFF (656144), NIH | Epidemiologic Studies (5U19CA148107-04),...

    Background: Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping microarray, the OncoArray. The...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Figlioli, Gisella; Bogliolo, Massimo; Catucci, Irene; Caleca, Laura; Lasheras, Sandra Viz; Pujol, Roser; Kiiski, Johanna I; Muranen, Taru A; Barnes, Daniel; Dennis, Joe; ...
    Publisher: HAL CCSD
    Project: EC | BIORISE (669026), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Center Support Gra... (3P30CA068485-21S4), NIH | Genetic Susceptibility An... (1Z01ES049033-10), NIH | Understanding Ethnic Diff... (5U01CA164973-04), NHMRC | Epidemiology of Chronic D... (209057), NIH | Automated Density Measure... (5R01CA177150-03), NIH | Risk and penetrance of mu... (5R01CA192393-02), NIH | Innovative Infrastructure... (5U01CA199277-02), EC | EUROFANCOLEN (305421),...

    Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a br...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Fara Brasó Maristany; Simone Filosto; Violeta Serra; Pascal Meier; Maggie Chon U Cheang; Richard Buus; Pau Castel; Anita Grigoriadis; Gris-Oliver A;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Triple-negative breast cancers (TNBCs) have poor prognosis and lack targeted therapies. Here we identified increased copy number and expression of the PIM1 proto-oncogene in genomic data sets of patients with TNBC. TNBC cells, but not nonmalignant mammary epithelial cel...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Francisco Sanchez-Vega; Andy Ni;
    Publisher: Cell Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Hellmann et al. examine non-small-cell lung cancers treated with combined PD-1 and CTLA-4 blockade using whole-exome sequencing and find that high tumor mutation burden is the strongest feature associated with improved objective response, durable benefit, and progressio...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Elvira Mass; Jeffery Molkentin; Simon Yona; Christoph Scheiermann; Andreas Margraf; Markus Sperandio;
    Publisher: Nature Publishing Group
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Macrophage development an... (1R01AI130345-01)

    Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which invade the developing embryo and persist by means of local self-renewal. However, the route and characteristics of YS macrophage trafficking during embryogenesis are incompletely und...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    P. Hammel; H.L. Kindler; M. Reni; E. Van Cutsem; T. Macarulla; M.J. Hall; J.O. Park; D. Hochhauser; D. Arnold; D.-Y. Oh; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    BACKGROUND: Patients with metastatic pancreatic cancer often have a detriment in health-related quality of life (HRQoL). In the randomized, double-blind, phase III POLO trial progression-free survival was significantly longer with maintenance olaparib, a poly(ADP-ribose...

  • publication . Article . 2016
    Open Access
    Authors:
    Permuth, J. B.; Reid, B.; Earp, M.; Chen, Y. A.; Monteiro, A. N. A.; Chen, Z.; Chenevix-Trench, G.; Fasching, P. A.; Beckmann, M. W.; Lambrechts, D.; ...
    Project: NIH | Epidemiology of Ovarian C... (5R01CA087538-02), NIH | Premenopausal Hormone Lev... (5R01CA067262-08), NIH | MOUSE GENETICS (2P30CA008748-43), NHMRC | Molecular Epidemiology of... (400281), NIH | Genetic Epidemiology of O... (5K07CA143047-02), NIH | ESTROGEN, DIET, GENETICS ... (5R01CA083918-04), NHMRC | Epidemiology of Chronic D... (209057), NIH | Mayo Clinic SPORE in Ovar... (3P50CA136393-05S1), NHMRC | Towards cancer control: P... (199600), NIH | COLLABORATIVE STUDY OF OV... (5R01CA058598-05),...

    RNA editing in mammals is a form of post-transcriptional modification in which adenosine is converted to inosine by the adenosine deaminases acting on RNA (ADAR) family of enzymes. Based on evidence of altered ADAR expression in epithelial ovarian cancers (EOC), we hypo...

  • publication . Other literature type . Article . 2016
    Open Access English
    Authors:
    Nitya Ramkumar; Wijnholds, J;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    During gastrulation of the mouse embryo, individual cells ingress in an apparently stochastic pattern during the epithelial-to-mesenchymal transition (EMT). Here we define a critical role of the apical protein Crumbs2 (CRB2) in the gastrulation EMT. Static and live imag...

  • publication . Article . 2020
    Open Access
    Authors:
    Oza, A. M.; Lorusso, D.; Aghajanian, C.; Oaknin, A.; Dean, A.; Colombo, N.; Weberpals, J. I.; Clamp, A. R.; Scambia, G.; Leary, A.; ...
    Publisher: American Society of Clinical Oncology (ASCO)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    <jats:sec><jats:title>PURPOSE</jats:title><jats:p> To investigate quality-adjusted progression-free survival (QA-PFS) and quality-adjusted time without symptoms or toxicity (Q-TWiST) in a post hoc exploratory analysis of the phase III ARIEL3 study of rucaparib maintenan...

  • publication . Article . 2020
    Open Access English
    Authors:
    Kevin Litchfield; James L. Reading; Emilia L. Lim; Hang Xu; Po Liu; Maise Al-Bakir; Yien Ning Sophia Wong; Andrew Rowan; Samuel A. Funt; Taha Merghoub; ...
    Publisher: Nature Publishing Group UK
    Project: EC | PLOIDYNET (607722), WT , NIH | MOUSE GENETICS (2P30CA008748-43), EC | PROTEUS (835297), RCUK | Lethal renal cell carcino... (MR/P014712/1), EC | THESEUS (617844), EC | CHROMAVISION (665233)

    Frameshift insertion/deletions (fs-indels) are an infrequent but highly immunogenic mutation subtype. Although fs-indels are degraded through the nonsense-mediated decay (NMD) pathway, we hypothesise that some fs-indels escape degradation and elicit anti-tumor immune re...

28 research outcomes, page 1 of 3
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