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7 research outcomes, page 1 of 1
  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Jiang, Xia; Finucane, Hilary K; Schumacher, Fredrick R; Schmit, Stephanie L; Tyrer, Jonathan; Han, Younghun; Michailidou, Kyriaki; Lesseur, Corina; Kuchenbaecker, Karoline B; Dennis, Joe; ...
    Publisher: Nature Publishing Group
    Project: NIH | The Vanderbilt Institute ... (6UL1TR000445-11), NIH | Discovery and verificatio... (5R01CA189184-04), NHMRC | Markers of androgen actio... (450104), NIH | The Mitochondrial Genome ... (5R01CA149429-05), NIH | Cancer Risk Reduction and... (2R37CA070867-12), NIH | Genes contributing for ni... (5R01DA017932-07), NIH | Consortium Study to Ident... (5R01CA148667-05), NIH | Career Development (Ingle... (5P50CA116201-08), NIH | Breast &prostate cancer &... (1U01CA098216-01), NIH | Characterizing Genetic Su... (5U01CA098710-06),...

    Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of Europ...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Alison P. Klein; Brian M. Wolpin; Harvey A. Risch; Rachael Z. Stolzenberg-Solomon; Evelina Mocci; Mingfeng Zhang; Federico Canzian; Erica J. Childs; Jason W. Hoskins; Ashley Jermusyk; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Womens Health Study: Cont... (1R01HL080467-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Vitamin D, Related Genes ... (2R01CA098661-06A2), NIH | Experimental Pathology (5P30CA016087-32), NIH | Pancreatic Cancer Genetic... (5R01CA097075-05), NIH | TRIAL OF ASPIRIN AND VITA... (5R01HL043851-08), NIH | PANCREATIC CANCER CASE CO... (3R01CA059706-01A1S1), NIH | Cancer Epidemiology Cohor... (5UM1CA167552-02), NIH | CALIFORNIA COORDINATED CA... (1U58DP003862-01), NIH | The Womens Health Study: ... (1RC1HL099355-01),...

    In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Glubb, Dylan M; Johnatty, Sharon E; Quinn, Michael CJ; O'Mara, Tracy A; Tyrer, Jonathan; Gao, Bo; Fasching, Peter A; Beckmann, Matthias W; Lambrechts, Diether; Vergote, Ignace; ...
    Publisher: Impact Journals
    Project: EC | COGS (223175), NIH | Inflammation and Ovarian ... (5R01CA095023-03), NIH | Regulatory T Cell Functio... (5R01CA126841-04), NIH | Discovery Expansion and R... (5U19CA148065-04), NHMRC | Australasian Biospecimen ... (628903), NIH | MOLECULAR EPIDEMIOLOGY OF... (5R01CA076016-04), NIH | Mayo Clinic SPORE in Ovar... (3P50CA136393-05S1), NHMRC | Towards cancer control: P... (199600), NIH | COLLABORATIVE STUDY OF OV... (5R01CA058598-05), NIH | The Mitochondrial Genome ... (5R01CA149429-05),...

    We previously identified associations with ovarian cancer outcome at five genetic loci. To identify putatively causal genetic variants and target genes, we prioritized two ovarian outcome loci (1q22 and 19p12) for further study. Bioinformatic and functional genetic anal...

  • publication . Preprint . Article . Other literature type . 2019
    Open Access
    Authors:
    Menchero, Sergio; Lopez-Izquierdo, Antonio; Rollan, Isabel; Sainz de Aja, Julio; Andreu, Maria Jose; Kang, Minjung; Adan, Javier; Benedito, Rui; Rayon, Teresa; Hadjantonakis, Anna-Katerina; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms driving cell f... (1R01HD094868-01), NIH | Morphogenesis of mammalia... (5R01DK084391-06), EC | AngioGenesHD (638028)

    The Notch signalling pathway plays fundamental roles in diverse developmental processes in metazoans, where it is important in driving cell fate and directing differentiation of various cell types. However, we still have limited knowledge about the role of Notch in earl...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    null null; Massimo Squatrito; Paolo Codega; Ingo Mellinghoff;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Molecular Mechanisms of I... (1R01NS080944-01), NIH | Molecular Mechanisms of D... (5R35NS105109-02)

    The epidermal growth factor receptor (EGFR) signalling is regulated at multiple levels. Here the authors show that the importin RanBP6 acts as a tumor suppressor in Glioblastoma and  regulates EGFR signalling through promoting translocation of STAT3 to the nuclei and re...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Figlioli, Gisella; Bogliolo, Massimo; Catucci, Irene; Caleca, Laura; Lasheras, Sandra Viz; Pujol, Roser; Kiiski, Johanna I; Muranen, Taru A; Barnes, Daniel; Dennis, Joe; ...
    Publisher: HAL CCSD
    Project: EC | BIORISE (669026), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Center Support Gra... (3P30CA068485-21S4), NIH | Genetic Susceptibility An... (1Z01ES049033-10), NIH | Understanding Ethnic Diff... (5U01CA164973-04), NHMRC | Epidemiology of Chronic D... (209057), NIH | Automated Density Measure... (5R01CA177150-03), NIH | Risk and penetrance of mu... (5R01CA192393-02), NIH | Innovative Infrastructure... (5U01CA199277-02), EC | EUROFANCOLEN (305421),...

    Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a br...

  • publication . Article . 2020
    Open Access English
    Authors:
    Thomas Reiner; Susanne Kossatz; Giacomo Pirovano; Carlos Pérez-Medina;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | PET nanoreporter image-gu... (1R01CA220234-01A1), NIH | Development of a Novel Pe... (5F32EB025050-02), NIH | Radioiodinated Multifunct... (1R01CA204441-01A1)

    The immune function within the tumor microenvironment has become a prominent therapeutic target, with tumor-associated macrophages (TAMs) playing a critical role in immune suppression. We propose an 89Zr-labeled high-density lipoprotein (89Zr-HDL) nanotracer as a means ...

7 research outcomes, page 1 of 1
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