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11 research outcomes, page 1 of 2
  • publication . Other literature type . Article . 2016 . Embargo End Date: 24 Aug 2016
    Open Access English
    Authors:
    Iratxe Macias; Leire Arreal; Charles Lawrie; roger gomis; Violeta Serra; Maria Vivanco; Marco Piva; Giacomo Domenici; Ana Rosa Cortazar; Patricia Zúñiga García; ...
    Publisher: Apollo - University of Cambridge Repository
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), EC | CANCERMETAB (336343)

    Patient stratification has been instrumental for the success of targeted therapies in breast cancer. However, the molecular basis of metastatic breast cancer and its therapeutic vulnerabilities remain poorly understood. Here we show that PML is a novel target in aggress...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Francesco Maura; Andrea Degasperi; Ferran Nadeu; Daniel Leongamornlert; Helen Davies; Luiza Moore; Romina Royo; Bachisio Ziccheddu; Xose S. Puente; Herve Avet-Loiseau; ...
    Publisher: Nature Publishing Group
    Project: WT , NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Career Development Progra... (5P50CA100707-13), NIH | MOLECULAR MANIPULATION TO... (5I01BX001584-04), EC | bECOMiNG (817997)

    Analysis of mutational signatures is becoming routine in cancer genomics, with implications for pathogenesis, classification, prognosis, and even treatment decisions. However, the field lacks a consensus on analysis and result interpretation. Using whole-genome sequenci...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Amos, CI; Dennis, Joe; Wang, Z; Byun, J; Schumacher, FR; Gayther, SA; Casey, G; Hunter, DJ; Sellers, TA; Gruber, SB; ...
    Publisher: American Association for Cancer Research
    Project: NIH | MOLECULAR EPIDEMIOLOGY OF... (5R01CA081488-05), NIH | Discovery Expansion and R... (5U19CA148065-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Career Development (Ingle... (5P50CA116201-08), NIH | Breast Cancer Family Regi... (1UM1CA164920-01A1), NIH | Mayo Clinic SPORE in Ovar... (3P50CA136393-05S1), NIH | Follow-up of Ovarian Canc... (3U19CA148112-04S1), NIH | Mayo Comprehensive Cancer... (3P30CA015083-37S2), EC | RADIOGENFF (656144), NIH | Epidemiologic Studies (5U19CA148107-04),...

    Background: Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping microarray, the OncoArray. The...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Sophie Morgani; Jennifer Nichols; Anna-Katerina Hadjantonakis;
    Publisher: BMC
    Project: WT , NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Morphogenesis of mammalia... (5R01DK084391-06)

    Abstract Pluripotency defines the propensity of a cell to differentiate into, and generate, all somatic, as well as germ cells. The epiblast of the early mammalian embryo is the founder population of all germ layer derivatives and thus represents the bona fide in vivo p...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Fittall, Matthew W; Mifsud, William; Pillay, Nischalan; Ye, Hongtao; Strobl, Anna-Christina; Verfaillie, Annelien; Demeulemeester, Jonas; Zhang, Lei; Berisha, Fitim; Tarabichi, Maxime; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), WT , EC | SIOMICS (747852), NIH | Administrative Core (5P50CA140146-04), EC | DECODE (703594)

    The transcription factor FOS has long been implicated in the pathogenesis of bone tumours, following the discovery that the viral homologue, v-fos, caused osteosarcoma in laboratory mice. However, mutations of FOS have not been found in human bone-forming tumours. Here,...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Obenauf, Anna C; Zou, Yilong; Ji, Andrew L; Vanharanta, Sakari; Shu, Weiping; Shi, Hubing; Kong, Xiangju; Bosenberg, Marcus C; Wiesner, Thomas; Rosen, Neal; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), FWF | The impact of stochastic ... (J 3013)

    Tumour cells respond to an effective, targeted drug treatment with BRAF, ALK or EGFR kinase inhibitors by inducing a complex network of secreted signals that promote tumour growth, dissemination and metastasis of drug-resistant cancer cell clones, and increase the survi...

  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Bick, Ulrich; Trimboli, Rubina M; Athanasiou, Alexandra; Balleyguier, Corinne; Baltzer, Pascal AT; Bernathova, Maria; Borbély, Krisztina; Brkljacic, Boris; Carbonaro, Luca A; Clauser, Paola; ...
    Publisher: Springer Berlin Heidelberg
    Project: NWO | XCiDE: Crossing the Combu... (2300153186), NIH | MOUSE GENETICS (2P30CA008748-43), EC | HYPMED (667211), EC | CANCER SCAN (828978)

    We summarise here the information to be provided to women and referring physicians about percutaneous breast biopsy and lesion localisation under imaging guidance. After explaining why a preoperative diagnosis with a percutaneous biopsy is preferred to surgical biopsy, ...

  • publication . Other literature type . Article . 2018 . Embargo End Date: 09 Jan 2019
    Open Access
    Authors:
    Cline, Melissa S; Liao, Rachel G; Parsons, Michael T; Paten, Benedict; Alquaddoomi, Faisal; Antoniou, Antonis; Baxter, Samantha; Brody, Larry; Cook-Deegan, Robert; Coffin, Amy; ...
    Publisher: Apollo - University of Cambridge Repository
    Project: NIH | Building the Medical Info... (5R01HG008918-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | EMERGE III CENTRAL SEQUEN... (5U01HG008676-02), NIH | Visualization hub for gen... (5U24CA210974-02), NIH | Cloud Based Resource for ... (5U24CA180951-05), NIH | The Future of PharmGKB Fu... (3U41HG009649-01S1), NHMRC | Research Fellowship – Gen... (1061779), NIH | Global Infrastructure for... (5U24CA210999-03), CIHR , NIH | Center for Big Data in Tr... (3U54HG007990-03S3),...

    The BRCA Challenge is a long-term data-sharing project initiated within the Global Alliance for Genomics and Health (GA4GH) to aggregate BRCA1 and BRCA2 data to support highly collaborative research activities. Its goal is to generate an informed and current understandi...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Elias Rodriguez-Fos; Anton Henssen; David Torrents; Ian C MacArthur; Richard Koche; Stephen Philip Jackson; Santiago Gonzalez Rosado;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | Clinical and Translationa... (3UL1TR000457-08S1), WT , NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Administrative Core (5P50CA140146-04)

    Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, including lethal rhabdoid tumors. Using assembly...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Reznik, Ed; Miller, Martin; Şenbabaoğlu, Yasin; Riaz, Nadeem; Sarungbam, Judy; Tickoo, Satish K; Al-Ahmadie, Hikmat A; Lee, William; Seshan, Venkatraman E; Hakimi, A Ari; ...
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MSKCC Center for Translat... (5U24CA143840-04)

    Mutations, deletions, and changes in copy number of mitochondrial DNA (mtDNA), are observed throughout cancers. Here, we survey mtDNA copy number variation across 22 tumor types profiled by The Cancer Genome Atlas project. We observe a tendency for some cancers, especia...

11 research outcomes, page 1 of 2
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