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10 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Sasha Madronich; Carlotta Sacerdote; LIDIA SACCHETTO;
    Publisher: Wiley
    Project: NIH | UNC-CH Center for Environ... (5P30ES010126-11), NIH | Solar Exposure and Melano... (1R01CA112524-01), NIH | Melanoma RAS/BRAF Mutatio... (5R01CA112243-10), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | A MODEL FOR GENETIC SUSCE... (5U01CA083180-03), NIH | University of New Mexico ... (5UL1TR000041-05), NIH | Melanoma NRAS/BRAF Mutati... (5K07CA102096-04)

    Abstract Autophagy has been linked with melanoma risk and survival, but no polymorphisms in autophagy‐related (ATG) genes have been investigated in relation to melanoma progression. We examined five single‐nucleotide polymorphisms (SNPs) in three ATG genes (ATG5; ATG10;...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Elias Rodriguez-Fos; Anton Henssen; David Torrents; Ian C MacArthur; Richard Koche; Stephen Philip Jackson; Santiago Gonzalez Rosado;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | Clinical and Translationa... (3UL1TR000457-08S1), WT , NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Administrative Core (5P50CA140146-04)

    Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, including lethal rhabdoid tumors. Using assembly...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Jiang, Xia; Finucane, Hilary K; Schumacher, Fredrick R; Schmit, Stephanie L; Tyrer, Jonathan; Han, Younghun; Michailidou, Kyriaki; Lesseur, Corina; Kuchenbaecker, Karoline B; Dennis, Joe; ...
    Publisher: Nature Publishing Group
    Project: NIH | The Vanderbilt Institute ... (6UL1TR000445-11), NIH | Discovery and verificatio... (5R01CA189184-04), NHMRC | Markers of androgen actio... (450104), NIH | The Mitochondrial Genome ... (5R01CA149429-05), NIH | Cancer Risk Reduction and... (2R37CA070867-12), NIH | Genes contributing for ni... (5R01DA017932-07), NIH | Consortium Study to Ident... (5R01CA148667-05), NIH | Career Development (Ingle... (5P50CA116201-08), NIH | Breast &prostate cancer &... (1U01CA098216-01), NIH | Characterizing Genetic Su... (5U01CA098710-06),...

    Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of Europ...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Pascal Guenel; bernard peissel; mikael eriksson; Thilo Dörk; Anna Jakubowska; Anna Marie Mulligan; Paolo Radice; Sara Olson; Peter Kraft; Florian Heitz; ...
    Project: NIH | Long Term Multidisciplina... (5UM1CA186107-05), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Epidemiology Cohor... (5UM1CA167552-02), NHMRC | Translation of PALB2 gene... (1029974), NHMRC | Personalized clinical gen... (1061177), NIH | MHC-Restricted and MHC-No... (1P50CA159981-01A1), NIH | OVARIAN CANCER RISK AND S... (5K07CA080668-06), WT | Understanding the genetic... (090532), NIH | DIET, HORMONES AND RISK O... (3P01CA087969-03S1), EC | COGS (223175),...

    <p style="-webkit-font-smoothing: antialiased; box-sizing: border-box; margin: 0px auto 10px; line-height: 2.5rem;"><strong style="-webkit-font-smoothing: antialiased; box-sizing: border-box;">Background:</strong> The rarity of mutations in <em style="-webkit-font-smoot...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Professor Rosalind Eeles; Nicola Nicolai; Elizabeth Bancroft; Marta Cardoso; Lidia Feliubadalo; Manuel R. Teixeira; Gareth Evans; Judith Offman;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    Background: Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-antigen (PSA) in men with germline BRCA1/2 mutations. Objective: To report the utility of ...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Amos, CI; Dennis, Joe; Wang, Z; Byun, J; Schumacher, FR; Gayther, SA; Casey, G; Hunter, DJ; Sellers, TA; Gruber, SB; ...
    Publisher: American Association for Cancer Research
    Project: NIH | MOLECULAR EPIDEMIOLOGY OF... (5R01CA081488-05), NIH | Discovery Expansion and R... (5U19CA148065-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Career Development (Ingle... (5P50CA116201-08), NIH | Breast Cancer Family Regi... (1UM1CA164920-01A1), NIH | Mayo Clinic SPORE in Ovar... (3P50CA136393-05S1), NIH | Follow-up of Ovarian Canc... (3U19CA148112-04S1), NIH | Mayo Comprehensive Cancer... (3P30CA015083-37S2), EC | RADIOGENFF (656144), NIH | Epidemiologic Studies (5U19CA148107-04),...

    Background: Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping microarray, the OncoArray. The...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Brenda Birmann; Giulio Genovese; Robert Handsaker;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NWO | Cluster computing in gene... (2300131050), NIH | Fast and accurate phasing... (5R21HG009513-02), NIH | Methods for Genome-wide A... (5R01HG006399-05), NIH | Joint Center for Mendelia... (5UM1HG008900-04), NIH | Clinical Diagnostic Seque... (1R01HD081256-01A1), NIH | Orchestra: A high perform... (1S10RR028832-01), NIH | Statistical methods for s... (5R01MH101244-02), NIH | Multi-allelic copy number... (5R01HG006855-02), NIH | Fast and powerful extensi... (1F32HG007805-01),...

    The selective pressures that shape clonal evolution in healthy individuals are largely unknown. Here we investigate 8,342 mosaic chromosomal alterations, from 50 kb to 249 Mb long, that we uncovered in blood-derived DNA from 151,202 UK Biobank participants using phase-b...

  • publication . Article . Other literature type . 2020
    Open Access
    Authors:
    León‐Castillo, Alicia; Gilvazquez, Ester; Nout, Remi; Smit, Vincent THBM; McAlpine, Jessica N; McConechy, Melissa; Kommoss, Stefan; Brucker, Sara Y; Carlson, Joseph W; Epstein, Elisabeth; ...
    Publisher: Wiley
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Endometrial carcinoma (EC) molecular classification based on four molecular subclasses identified in The Cancer Genome Atlas (TCGA) has gained relevance in recent years due to its prognostic utility and potential to predict benefit from adjuvant treatment. While most EC...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Wu, Xiaoning; Scott, Helen; Carlsson, Sigrid V.; Sjoberg, Daniel D.; Cerundolo, Lucia; Lilja, Hans; Prevo, Remko; Rieunier, Guillaume; Macaulay, Valentine; Higgins, Geoffrey S.; ...
    Publisher: Wiley
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    Background\ud \ud Enhancer of zeste 2 (EZH2) promotes prostate cancer progression. We hypothesized that increased EZH2 expression is associated with postradiotherapy metastatic disease recurrence, and may promote radioresistance.\ud \ud \ud \ud Methods\ud \ud EZH2 expre...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Sridhar, Akshay; Ross, Gregory A.; Biggin, Philip C.;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    : Water is often found to mediate interactions between a ligand and a protein. It can play a significant role in orientating the ligand within a binding pocket and contribute to the free energy of binding. It would thus be extremely useful to be able to accurately predi...

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