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9 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Pierre-Louis Loyher; Pauline Hamon; Marie Laviron; Aïda Meghraoui-Kheddar; Elena Goncalves; Zihou Deng; Sara Torstensson; Nadège Bercovici; Camille Baudesson de Chanville; Béhazine Combadière; ...
    Publisher: Rockefeller University Press
    Project: NIH | Lineages and pathophysiol... (5R01HL138090-02), NIH | MOUSE GENETICS (2P30CA008748-43), EC | RAIDS (304810), NIH | Macrophage development an... (1R01AI130345-01)

    Loyher et al. demonstrate that lung tumors are densely colonized by macrophages of various ontogenies. These distinct developmental origins dictate tumor-associated macrophages relative anatomical distributions, functions and responses to anti-cancer therapies.

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Francesco Maura; Niccoló Bolli; Nicos Angelopoulos; Kevin J. Dawson; Daniel Leongamornlert; Inigo Martincorena; Thomas J. Mitchell; Anthony Fullam; Santiago Gonzalez; Raphael Szalat; ...
    Publisher: HAL CCSD
    Project: NIH | MOLECULAR MANIPULATION TO... (5I01BX001584-04), NIH | MOUSE GENETICS (2P30CA008748-43), EC | bECOMiNG (817997), NIH | Career Development Progra... (5P50CA100707-13)

    The multiple myeloma (MM) genome is heterogeneous and evolves through preclinical and post-diagnosis phases. Here we report a catalog and hierarchy of driver lesions using sequences from 67 MM genomes serially collected from 30 patients together with public exome datase...

  • publication . Article . Other literature type . Preprint . 2019
    Open Access
    Authors:
    Edwige B. Garcin; Stéphanie Gon; Meghan R. Sullivan; Gregory J. Brunette; Anne De Cian; Jean-Paul Concordet; Carine Giovannangeli; Wilhelm G. Dirks; Sonja Eberth; Kara A. Bernstein; ...
    Publisher: Public Library of Science (PLoS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | The interplay between RAD... (5F31ES027321-02), NIH | Fluorescence microscopy f... (3R35GM118175-01S1), NIH | Deciphering the epistatic... (5F32GM110978-02), NIH | HOMOLOGY-DIRECTED DNA REP... (5R01CA185660-04)

    Deficiency in several of the classical human RAD51 paralogs [RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3] is associated with cancer predisposition and Fanconi anemia. To investigate their functions, isogenic disruption mutants for each were generated in non-transformed MCF1...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Sebastian Müller; Loew Damarys; Kevin Sullivan; Lisa Prendergast; Genevieve Almouzni;
    Publisher: HAL CCSD
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), EC | EPIGENESYS (257082), SFI | Assembly of centromeric c... (05/RP1/B793), SFI | Structure and assembly of... (12/IA/1370), EC | MODHEP (259743)

    International audience; The CENP-T/-W histone fold complex, as an integral part of the inner kinetochore, is essential for building a proper kinetochore at the centromere in order to direct chromosome segregation during mitosis. Notably, CENP-T/-W is not inherited at ce...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Ajay Gopal; Martin Hutchings; Ranjana Advani; PIER LUIGI ZINZANI;
    Publisher: HAL CCSD
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Biostatistics and Bioinfo... (2P50CA097274-06)

    International audience; In recent years, the number of approved and investigational agents that can be safely administered for the treatment of lymphoma patients for a prolonged period of time has substantially increased. Many of these novel agents are evaluated in earl...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Maxime Deforet; Leila Akkari;
    Publisher: HAL CCSD
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | The CSBC Research Center ... (3U54CA209975-01S1), NIH | Using extracellular metab... (4R00CA191021-03)

    <jats:p>The genetic and phenotypic diversity of cells within tumors is a major obstacle for cancer treatment. Because of the stochastic nature of genetic alterations, this intratumoral heterogeneity is often viewed as chaotic. Here we show that the altered metabolism of...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Shan Tan; Clovis Tauber; Dimitris VISVIKIS; Vincent Jaouen;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Quantitative PET/CT Analy... (4R01CA172638-04)

    Abstract Introduction Automatic functional volume segmentation in PET images is a challenge that has been addressed using a large array of methods. A major limitation for the field has been the lack of a benchmark dataset that would allow direct comparison of the result...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Boire, Adrienne; Brandsma, Dieta; Brastianos, Priscilla K; Le Rhun, Emilie; Ahluwalia, Manmeet; Junck, Larry; Glantz, Michael; Groves, Morris D; Lee, Eudocia Q; Lin, Nancy; ...
    Publisher: Oxford University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    markdownabstractAbstract Liquid biopsies collect and analyze tumor components in body fluids, and there is an increasing interest in the investigation of liquid biopsies as a surrogate for tumor tissue in the management of both primary and secondary brain tumors. Herein...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Scott Keeney; MEHMET ERMAN KARASU; Katja Wassmann;
    Publisher: Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Cyclins control the switch-like cell cycle transitions that orchestrate orderly duplication and segregation of genomes. Karasu et al. delineate an essential function for mouse cyclin B3 for anaphase onset in the first meiotic division of oocytes.

9 research outcomes, page 1 of 1
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