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7 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    David Brown;
    Publisher: Springer
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Breast adenomyoepitheliomas (AMEs) are rare epithelial-myoepithelial neoplasms that may occasionally produce myxochondroid matrix, akin to pleomorphic adenomas (PAs). Regardless of their anatomic location, PAs often harbor rearrangements involving HMGA2 or PLAG1. We hav...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Smita Krishnaswamy; Nevena Zivanovic; Roshan Sharma; Dana Pe’er; Bernd Bodenmiller;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Integrative Cancer Genomi... (5R01CA164729-03), NIH | Single cell mapping of de... (7DP1HD084071-04)

    Cellular regulatory networks are not static, but continuously reconfigure in response to stimuli via alterations in protein abundance and confirmation. However, typical computational approaches treat them as static interaction networks derived from a single time point. ...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Bernhard Reis; Dana Pe'er; Craig Gedye; Vito Riccardo Tomaso Zanotelli; Maries van den Broek;
    Publisher: Elsevier BV
    Project: CIHR , NHMRC | Characterization of Ovari... (628939), NIH | MOUSE GENETICS (2P30CA008748-43), EC | LTFCOFUND2013 (609409), NIH | Integrative Cancer Genomi... (5R01CA164729-03), EC | SIGNALING 3D (336921), NIH | Single cell mapping of de... (7DP1HD084071-04)

    Applying mass cytometry for high-dimensional single-cell analysis depicts an in-depth atlas of the immune microenvironment in clear cell renal cell carcinoma patients, thereby linking immune compositions with clinical features.

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Peter Ly; Dana Pe'er; Charles Swanton; Don W Cleveland; Ashley Laughney; Nicolai Birkbak; Rajasekhar Vinagolu; Bryan Ngo;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Cell Division Errors as a... (5K99CA218871-02), NIH | MOUSE GENETICS (2P30CA008748-43), NSF | CAREER:The role of nuclea... (1254846), NIH | Phosphoinositides and Can... (5R35CA197588-02), NIH | Nuclear mechanics and mec... (7R01HL082792-06), NIH | Social, Cultural and Cont... (1R03CA150580-01)

    Chromosomal instability is a hallmark of cancer that results from ongoing errors in chromosome segregation during mitosis. Although chromosomal instability is a major driver of tumour evolution, its role in metastasis has not been established. Here we show that chromoso...

  • publication . Other literature type . Article . 2017 . Embargo End Date: 01 Jun 2017
    Open Access
    Authors:
    Kevin P O'Rourke; Evangelia Loizou; Geulah Livshits; Emma M Schatoff; Timour Baslan; Eusebio Manchado; Janelle Simon; Paul B Romesser; Benjamin Leach; Teng Han; ...
    Publisher: Nature Publishing Group
    Project: NIH | A scalable platform for t... (1R01CA195787-01), SNSF | GENETICS AND EPIGENETICS ... (P2BEP3_152100), NIH | Modeling metastatic color... (5F30CA200110-02), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Defining the genetic requ... (5K22CA181280-02), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    Colorectal cancer (CRC) is a leading cause of death in the developed world, yet facile preclinical models that mimic the natural stages of CRC progression are lacking. Through the orthotopic engraftment of colon organoids we describe a broadly usable immunocompetent CRC...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Boire, Adrienne; Brandsma, Dieta; Brastianos, Priscilla K; Le Rhun, Emilie; Ahluwalia, Manmeet; Junck, Larry; Glantz, Michael; Groves, Morris D; Lee, Eudocia Q; Lin, Nancy; ...
    Publisher: Oxford University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    markdownabstractAbstract Liquid biopsies collect and analyze tumor components in body fluids, and there is an increasing interest in the investigation of liquid biopsies as a surrogate for tumor tissue in the management of both primary and secondary brain tumors. Herein...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Kasthuri Kannan; Michael Platten; David T. W. Jones; FELICE GIANGASPERO; Marina Ryzhova; Lukas Chavez; Andrey Korshunov; Ori Staszewski; Michael D. Taylor; Matthias Karajannis; ...
    Project: NIH | Multidisciplinary Subspec... (5T32CA163185-04), NIH | MOUSE GENETICS (2P30CA008748-43)

    Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging—with substantia...

7 research outcomes, page 1 of 1
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