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10 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Shuchi Agrawal Singh; Mads Lerdrup; Ana-Luisa R Gomes; Harmen JG van de Werken; Jens Vilstrup Johansen; Robin Andersson; Albin Sandelin; Kristian Helin; Klaus Hansen;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), WT

    textabstractThe PLZF transcription factor is essential for osteogenic differentiation of hMSCs; however, its regulation and molecular function during this process is not fully understood. Here, we revealed that the ZBTB16 locus encoding PLZF, is repressed by Polycomb (P...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Jiang, Xia; Finucane, Hilary K; Schumacher, Fredrick R; Schmit, Stephanie L; Tyrer, Jonathan; Han, Younghun; Michailidou, Kyriaki; Lesseur, Corina; Kuchenbaecker, Karoline B; Dennis, Joe; ...
    Publisher: Nature Publishing Group
    Project: NIH | The Vanderbilt Institute ... (6UL1TR000445-11), NIH | Discovery and verificatio... (5R01CA189184-04), NHMRC | Markers of androgen actio... (450104), NIH | The Mitochondrial Genome ... (5R01CA149429-05), NIH | Cancer Risk Reduction and... (2R37CA070867-12), NIH | Genes contributing for ni... (5R01DA017932-07), NIH | Consortium Study to Ident... (5R01CA148667-05), NIH | Career Development (Ingle... (5P50CA116201-08), NIH | Breast &prostate cancer &... (1U01CA098216-01), NIH | Characterizing Genetic Su... (5U01CA098710-06),...

    Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of Europ...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Pascal Guenel; bernard peissel; mikael eriksson; Thilo Dörk; Anna Jakubowska; Anna Marie Mulligan; Paolo Radice; Sara Olson; Peter Kraft; Florian Heitz; ...
    Project: NIH | Long Term Multidisciplina... (5UM1CA186107-05), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Epidemiology Cohor... (5UM1CA167552-02), NHMRC | Translation of PALB2 gene... (1029974), NHMRC | Personalized clinical gen... (1061177), NIH | MHC-Restricted and MHC-No... (1P50CA159981-01A1), NIH | OVARIAN CANCER RISK AND S... (5K07CA080668-06), WT | Understanding the genetic... (090532), NIH | DIET, HORMONES AND RISK O... (3P01CA087969-03S1), EC | COGS (223175),...

    <p style="-webkit-font-smoothing: antialiased; box-sizing: border-box; margin: 0px auto 10px; line-height: 2.5rem;"><strong style="-webkit-font-smoothing: antialiased; box-sizing: border-box;">Background:</strong> The rarity of mutations in <em style="-webkit-font-smoot...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Torben Heick Jensen; William Garland; Kristian Helin;
    Publisher: Elsevier
    Project: EC | EURECA (339953), NIH | MOUSE GENETICS (2P30CA008748-43), EC | DNAmethAML (749362)

    ZFC3H1 targets pA+ RNA for decay by the nuclear RNA exosome. Garland et al. report a disruptive relationship between excess RNA and PRC2 upon depletion of ZFC3H1 in mouse ESCs. In such conditions, RNA is bound by PRC2 components, which show reduced binding to chromatin ...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Glubb, Dylan M; Johnatty, Sharon E; Quinn, Michael CJ; O'Mara, Tracy A; Tyrer, Jonathan; Gao, Bo; Fasching, Peter A; Beckmann, Matthias W; Lambrechts, Diether; Vergote, Ignace; ...
    Publisher: Impact Journals
    Project: EC | COGS (223175), NIH | Inflammation and Ovarian ... (5R01CA095023-03), NIH | Regulatory T Cell Functio... (5R01CA126841-04), NIH | Discovery Expansion and R... (5U19CA148065-04), NHMRC | Australasian Biospecimen ... (628903), NIH | MOLECULAR EPIDEMIOLOGY OF... (5R01CA076016-04), NIH | Mayo Clinic SPORE in Ovar... (3P50CA136393-05S1), NHMRC | Towards cancer control: P... (199600), NIH | COLLABORATIVE STUDY OF OV... (5R01CA058598-05), NIH | The Mitochondrial Genome ... (5R01CA149429-05),...

    We previously identified associations with ovarian cancer outcome at five genetic loci. To identify putatively causal genetic variants and target genes, we prioritized two ovarian outcome loci (1q22 and 19p12) for further study. Bioinformatic and functional genetic anal...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Ostrom, Quinn T.; Kinnersley, Ben; Wrensch, Margaret R.; Eckel-Passow, Jeanette E.; Armstrong, Georgina; Rice, Terri; Chen, Yanwen; Wiencke, John K.; McCoy, Lucie S.; Hansen, Helen M.; ...
    Publisher: Nature Publishing Group UK
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | BRAIN TUMOR SPORT GRANT (5P50CA097257-12), NIH | Genetic and Molecular Epi... (5R01CA052689-13), NIH | Clinical and Translationa... (3UL1RR024131-03S3), NIH | Baylor College of Medicin... (3P30CA125123-09S3), WT , NIH | International Case Contro... (1R01CA139020-01A1), NIH | CALIFORNIA COORDINATED CA... (1U58DP003862-01), NIH | Biomarkers of survival in... (5R01CA126831-04)

    <p>Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) ha...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Figlioli, Gisella; Bogliolo, Massimo; Catucci, Irene; Caleca, Laura; Lasheras, Sandra Viz; Pujol, Roser; Kiiski, Johanna I; Muranen, Taru A; Barnes, Daniel; Dennis, Joe; ...
    Publisher: HAL CCSD
    Project: EC | BIORISE (669026), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Center Support Gra... (3P30CA068485-21S4), NIH | Genetic Susceptibility An... (1Z01ES049033-10), NIH | Understanding Ethnic Diff... (5U01CA164973-04), NHMRC | Epidemiology of Chronic D... (209057), NIH | Automated Density Measure... (5R01CA177150-03), NIH | Risk and penetrance of mu... (5R01CA192393-02), NIH | Innovative Infrastructure... (5U01CA199277-02), EC | EUROFANCOLEN (305421),...

    Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a br...

  • publication . Article . Other literature type . 2020
    Open Access
    Authors:
    Kim, Sarah H.; Da Cruz Paula, Arnaud; Basili, Thais; Dopeso, Higinio; Bi, Rui; Pareja, Fresia; da Silva, Edaise M.; Gularte-Mérida, Rodrigo; Sun, Zhen; Fujisawa, Sho; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Sclerosing stromal tumor (SST) of the ovary is a rare type of sex cord-stromal tumor (SCST), whose genetic underpinning is currently unknown. Here, using whole-exome, targeted capture and RNA-sequencing, we report recurrent FHL2-GLI2 fusion genes in 65% (17/26) of SSTs ...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Claus Garbe; Per thor Straten; Gennaro Ciliberto; Connie Duong;
    Publisher: BMC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Abstract Major advances have been made in the treatment of cancer with targeted therapy and immunotherapy; several FDA-approved agents with associated improvement of 1-year survival rates became available for stage IV melanoma patients. Before 2010, the 1-year survival ...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Kelemen, Linda E; Earp, Madalene; Fridley, Brooke L; Chenevix-Trench, Georgia; Australian Ovarian Cancer Study Group,; Fasching, Peter A; Beckmann, Matthias W; Ekici, Arif B; Hein, Alexander; Lambrechts, Diether; ...
    Publisher: eScholarship, University of California
    Project: NIH | MOLECULAR EPIDEMIOLOGY OF... (5R01CA076016-04), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01CN025403-000), NIH | Epidemiology of Ovarian C... (5R01CA087538-02), NIH | INTERNAL COUNCIL FOR TOBA... (1R01CA087696-01), NIH | Obesity in ovarian cancer... (5K22CA138563-02), NIH | Haplotype-Based Genome Sc... (1R01CA114343-01A2), NIH | Risk Factors for Breast C... (5R01CA050385-18), NIH | The Progesterone Receptor... (1R03CA113148-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MHC-Restricted and MHC-No... (1P50CA159981-01A1),...

    95% CI = 1.03–1.24

10 research outcomes, page 1 of 1
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