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8 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Kelemen, Linda E; Earp, Madalene; Fridley, Brooke L; Chenevix-Trench, Georgia; Australian Ovarian Cancer Study Group,; Fasching, Peter A; Beckmann, Matthias W; Ekici, Arif B; Hein, Alexander; Lambrechts, Diether; ...
    Publisher: eScholarship, University of California
    Project: NIH | MOLECULAR EPIDEMIOLOGY OF... (5R01CA076016-04), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01CN025403-000), NIH | Epidemiology of Ovarian C... (5R01CA087538-02), NIH | INTERNAL COUNCIL FOR TOBA... (1R01CA087696-01), NIH | Obesity in ovarian cancer... (5K22CA138563-02), NIH | Haplotype-Based Genome Sc... (1R01CA114343-01A2), NIH | Risk Factors for Breast C... (5R01CA050385-18), NIH | The Progesterone Receptor... (1R03CA113148-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MHC-Restricted and MHC-No... (1P50CA159981-01A1),...

    95% CI = 1.03–1.24

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Professor Rosalind Eeles; Nicola Nicolai; Elizabeth Bancroft; Marta Cardoso; Lidia Feliubadalo; Manuel R. Teixeira; Gareth Evans; Judith Offman;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    Background: Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-antigen (PSA) in men with germline BRCA1/2 mutations. Objective: To report the utility of ...

  • publication . Article . 2017
    Open Access
    Authors:
    Gregory A. Ross; Hannah E. Bruce Macdonald; Christopher Cave-Ayland; Ana I. Cabedo Martinez; Jonathan W. Essex;
    Publisher: American Chemical Society (ACS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), RCUK | CCP-BioSim: Biomolecular ... (EP/J010189/1), RCUK | A Doctoral Training Centr... (EP/G03690X/1), RCUK | EPSRC Centre for Doctoral... (EP/L015722/1)

    The ability of grand canonical Monte Carlo (GCMC) to create and annihilate molecules in a given region greatly aids the identification of water sites and water binding free energies in protein cavities. However, acceptance rates without the application of biased moves c...

  • publication . Article . 2018
    Open Access English
    Authors:
    Vigdis Stefansdottir; Diana M Eccles; Elena Castro; Professor Rosalind Eeles; Nicola Nicolai; Hans Vasen; Elizabeth Bancroft; Jan Lubinski; Lidia Feliubadalo; Manuel R. Teixeira; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Background: Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Figlioli, Gisella; Bogliolo, Massimo; Catucci, Irene; Caleca, Laura; Lasheras, Sandra Viz; Pujol, Roser; Kiiski, Johanna I; Muranen, Taru A; Barnes, Daniel; Dennis, Joe; ...
    Publisher: HAL CCSD
    Project: EC | BIORISE (669026), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Center Support Gra... (3P30CA068485-21S4), NIH | Genetic Susceptibility An... (1Z01ES049033-10), NIH | Understanding Ethnic Diff... (5U01CA164973-04), NHMRC | Epidemiology of Chronic D... (209057), NIH | Automated Density Measure... (5R01CA177150-03), NIH | Risk and penetrance of mu... (5R01CA192393-02), NIH | Innovative Infrastructure... (5U01CA199277-02), EC | EUROFANCOLEN (305421),...

    Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a br...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Valentina Mercurio; lucie null; Magid Awadalla; stephane ederhy; Maeve Jones-O'Connor; Paaladinesh Thavendiranathan; Michael Mahmoudi; Malek Z. Hassan;
    Publisher: BioMed Central
    Project: NIH | Promoting Bim-driven apop... (5R01CA193970-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | STOP-CA: Statins to preve... (1R01HL130539-01A1), NIH | Clinical development of a... (1UH2CA207355-01A1), NIH | Cardiovascular Imaging in... (5K24HL113128-07), NIH | Abbreviated targeted ther... (1R01CA229851-01), NIH | Harvard Medical School Ce... (1P30AI060354-01), CIHR , NIH | Mechanisms of Cardiac Dys... (1R01HL137562-01A1)

    Background Influenza vaccination (FV) is recommended for patients with cancer. Recent data suggested that the administration of the FV was associated with an increase in immune-related adverse events (irAEs) among patients on immune checkpoint inhibitors (ICIs). Myocard...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Jiang, Xia; Finucane, Hilary K; Schumacher, Fredrick R; Schmit, Stephanie L; Tyrer, Jonathan; Han, Younghun; Michailidou, Kyriaki; Lesseur, Corina; Kuchenbaecker, Karoline B; Dennis, Joe; ...
    Publisher: Nature Publishing Group
    Project: NIH | The Vanderbilt Institute ... (6UL1TR000445-11), NIH | Discovery and verificatio... (5R01CA189184-04), NHMRC | Markers of androgen actio... (450104), NIH | The Mitochondrial Genome ... (5R01CA149429-05), NIH | Cancer Risk Reduction and... (2R37CA070867-12), NIH | Genes contributing for ni... (5R01DA017932-07), NIH | Consortium Study to Ident... (5R01CA148667-05), NIH | Career Development (Ingle... (5P50CA116201-08), NIH | Breast &prostate cancer &... (1U01CA098216-01), NIH | Characterizing Genetic Su... (5U01CA098710-06),...

    Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of Europ...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Pascal Guenel; bernard peissel; mikael eriksson; Thilo Dörk; Anna Jakubowska; Anna Marie Mulligan; Paolo Radice; Sara Olson; Peter Kraft; Florian Heitz; ...
    Project: NIH | Long Term Multidisciplina... (5UM1CA186107-05), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Epidemiology Cohor... (5UM1CA167552-02), NHMRC | Translation of PALB2 gene... (1029974), NHMRC | Personalized clinical gen... (1061177), NIH | MHC-Restricted and MHC-No... (1P50CA159981-01A1), NIH | OVARIAN CANCER RISK AND S... (5K07CA080668-06), WT | Understanding the genetic... (090532), NIH | DIET, HORMONES AND RISK O... (3P01CA087969-03S1), EC | COGS (223175),...

    <p style="-webkit-font-smoothing: antialiased; box-sizing: border-box; margin: 0px auto 10px; line-height: 2.5rem;"><strong style="-webkit-font-smoothing: antialiased; box-sizing: border-box;">Background:</strong> The rarity of mutations in <em style="-webkit-font-smoot...

8 research outcomes, page 1 of 1
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