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13 research outcomes, page 1 of 2
  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Michal Neeman; Willem Mulder; Carlos Pérez-Medina; Jun Tang; Menno de Winther; Max Senders; francois fay; Thomas Reiner; Nicole van der Wel;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Nanoparticles for Molecul... (9R01EB009638-05A2), NWO | EFFECT Exploiting Filtere... (2300149327), NIH | PET/MRI to study nanother... (1R01HL125703-01), NIH | Anti-inflammatory nanopar... (1R01HL118440-01A1), EC | NANOATHERO (309820)

    Hyaluronan is a biologically active polymer, which can be formulated into nanoparticles. In our study, we aimed to probe atherosclerosis-associated inflammation by using hyaluronan nanoparticles and to determine whether they can ameliorate atherosclerosis. Hyaluronan na...

  • publication . Article . 2016
    Open Access English
    Authors:
    Alena M Gallegos; Huizhong Xiong; Ingrid M Leiner; Bože Sušac; Michael S Glickman; Eric G Pamer; Jeroen W J van Heijst;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Regulation of the CD4 T c... (5F32AI074248-02), NIH | CD4 T Cell Responses to M... (1R01AI080619-01A1)

    The T cell antigen receptor (TCR) is unique in that its affinity for ligand is unknown before encounter and can vary by orders of magnitude. How the immune system regulates individual T cells that display very different reactivity to antigen remains unclear. Here we fou...

  • publication . Article . 2018
    Open Access English
    Authors:
    van der Velden, Bas H. M.; Sutton, Elizabeth J.; Carbonaro, Luca A.; Pijnappel, Ruud M.; Morris, Elizabeth A.; Gilhuijs, Kenneth G. A.;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    To assess whether contralateral parenchymal enhancement reproduces as an independent biomarker for patient survival in an independent patient cohort from a different cancer institution. This is a HIPAA-compliant IRB approved retrospective study. Patients with ER-positiv...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Pascal Guenel; bernard peissel; mikael eriksson; Thilo Dörk; Anna Jakubowska; Anna Marie Mulligan; Paolo Radice; Sara Olson; Peter Kraft; Florian Heitz; ...
    Project: NIH | Long Term Multidisciplina... (5UM1CA186107-05), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Epidemiology Cohor... (5UM1CA167552-02), NHMRC | Translation of PALB2 gene... (1029974), NHMRC | Personalized clinical gen... (1061177), NIH | MHC-Restricted and MHC-No... (1P50CA159981-01A1), NIH | OVARIAN CANCER RISK AND S... (5K07CA080668-06), WT | Understanding the genetic... (090532), NIH | DIET, HORMONES AND RISK O... (3P01CA087969-03S1), EC | COGS (223175),...

    <p style="-webkit-font-smoothing: antialiased; box-sizing: border-box; margin: 0px auto 10px; line-height: 2.5rem;"><strong style="-webkit-font-smoothing: antialiased; box-sizing: border-box;">Background:</strong> The rarity of mutations in <em style="-webkit-font-smoot...

  • publication . Article . 2016
    Open Access
    Authors:
    Vriend, Lianne E. M.; Prakash, Rohit; Chen, Chun-Chin; Vanoli, Fabio; Cavallo, Francesca; Zhang, Yu; Jasin, Maria; Krawczyk, Przemek M.;
    Publisher: Oxford University Press (OUP)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Double-strand break repai... (5R01GM054668-08)

    Abstract DNA double-strand breaks (DSBs) are known to be powerful inducers of homologous recombination (HR), but single-strand breaks (nicks) have also been shown to trigger HR. Both DSB- and nick-induced HR (nickHR) are exploited in advanced genome-engineering approach...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Kasthuri Kannan; Michael Platten; David T. W. Jones; FELICE GIANGASPERO; Marina Ryzhova; Lukas Chavez; Andrey Korshunov; Ori Staszewski; Michael D. Taylor; Matthias Karajannis; ...
    Project: NIH | Multidisciplinary Subspec... (5T32CA163185-04), NIH | MOUSE GENETICS (2P30CA008748-43)

    Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging—with substantia...

  • publication . Article . 2017
    Open Access English
    Authors:
    Julius C. Fischer; Michael Bscheider; Gabriel Eisenkolb; Chia-Ching Lin; Alexander Wintges; Vera Otten; Caroline A. Lindemans; Simon Heidegger; Martina Rudelius; Sébastien Monette; ...
    Project: NIH | Strategies to enhance imm... (5R01HL069929-12), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | IL-22 in Thymic Regenerat... (5R01AI101406-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Strategies to Enhance Lym... (5R01AI080455-02), EC | CBM-INNATE (322865), NIH | Mucosal Immunity and Micr... (9R01AI100288-06A1)

    The molecular pathways that regulate the tissue repair function of type I interferon (IFN-I) during acute tissue damage are poorly understood. We describe a protective role for IFN-I and the RIG-I/MAVS signaling pathway during acute tissue damage in mice. Mice lacking m...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    P. Hammel; H.L. Kindler; M. Reni; E. Van Cutsem; T. Macarulla; M.J. Hall; J.O. Park; D. Hochhauser; D. Arnold; D.-Y. Oh; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    BACKGROUND: Patients with metastatic pancreatic cancer often have a detriment in health-related quality of life (HRQoL). In the randomized, double-blind, phase III POLO trial progression-free survival was significantly longer with maintenance olaparib, a poly(ADP-ribose...

  • publication . Article . 2020
    Open Access English
    Authors:
    Thomas Reiner; Susanne Kossatz; Giacomo Pirovano; Carlos Pérez-Medina;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | PET nanoreporter image-gu... (1R01CA220234-01A1), NIH | Development of a Novel Pe... (5F32EB025050-02), NIH | Radioiodinated Multifunct... (1R01CA204441-01A1)

    The immune function within the tumor microenvironment has become a prominent therapeutic target, with tumor-associated macrophages (TAMs) playing a critical role in immune suppression. We propose an 89Zr-labeled high-density lipoprotein (89Zr-HDL) nanotracer as a means ...

  • publication . Other literature type . Article . 2016
    Open Access English
    Authors:
    Nitya Ramkumar; Wijnholds, J;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    During gastrulation of the mouse embryo, individual cells ingress in an apparently stochastic pattern during the epithelial-to-mesenchymal transition (EMT). Here we define a critical role of the apical protein Crumbs2 (CRB2) in the gastrulation EMT. Static and live imag...

13 research outcomes, page 1 of 2
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