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12 research outcomes, page 1 of 2
  • publication . Article . 2015
    Open Access English
    Authors:
    Liu, Zhong; Skamagki, Maria; Kim, Kitai; Zhao, Rui;
    Publisher: The Authors. Published by Elsevier Inc.
    Project: NIH | Hematopoietic potential o... (5R00HL093212-04), NIH | Analytic and Preparative ... (5P30AR048311-08), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | A new hypothesis: role of... (5R01AG043531-04), NIH | UAB Center for AIDS Resea... (5P30AI027767-20)

    Highlights • Reprogramming may be initiated and maintained solely by transcription factors • miRNA activity as a whole facilitates reprogramming • Canonical miRNAs may be dispensable for reprogramming

  • publication . Article . 2016
    Open Access English
    Authors:
    John Petrini; Jane Skok; Gunnar Schotta;
    Publisher: Elsevier
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | P95--LINKING DSB REPAIR A... (7R01GM059413-04)

    Graphical Abstract

  • publication . Article . 2013
    Open Access
    Authors:
    D’Hulst, Charlotte; Parvanova, Irena; Tomoiaga, Delia; Sapar, Maria L.; Feinstein, Paul;
    Publisher: Elsevier BV
    Project: NIH | Regulation of Odorant Rec... (1SC1GM088114-01A1), NIH | MOUSE GENETICS (2P30CA008748-43)

    Highlights • Fast aneuploidy detection of mESCs using quantitative real-time PCR • Simultaneous processing of multiple cell lines • Highly sensitive: identifies low percentage of aneuploidy within an ESC clone • Method can detect loss or gain of any chromosomal region o...

  • publication . Other literature type . Article . 2014
    Open Access
    Authors:
    Christian Brand; Thomas Reiner;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    AbstractNew intravital optical imaging technologies have revolutionized our understanding of mammalian biology and continue to evolve rapidly. However, there are only a limited number of imaging probes available to date. In this study, we investigated in mouse models of...

  • publication . Article . 2011
    Open Access English
    Authors:
    Yuichiro Takagi; Tsuyoshi Imasaki; Gang Cai; Kuang-Lei Tsai; Kentaro Yamada; Imre Berger; Francisco J. Asturias;
    Publisher: Biophysical Society. Published by Elsevier Inc.
    Project: NIH | Technical Assistance to S... (Y1GM1104-15-0-1), NSF | High Resolution Structura... (0843026), NIH | Gene Activation In Vitro (5R01GM036659-26), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of euk... (7R01GM067167-12)
  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    GIUSEPPE PETRALIA; David Collins; Giuseppe PETRALIA; STEFANO FANTI; Dow-Mu Koh;
    Publisher: European Association of Urology. Published by Elsevier B.V.
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Context Comparative reviews of whole-body magnetic resonance imaging (WB-MRI) and positron emission tomography/computed tomography (CT; with different radiotracers) have shown that metastasis detection in advanced cancers is more accurate than with currently used CT and...

  • publication . Other literature type . Article . 2015
    Open Access
    Authors:
    Geoffrey Hespe; Ira Savetsky; Daniel Cuzzone; Raghu Kataru;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of fibrosis an... (4R01HL111130-05)

    Obesity is a major risk factor for inflammatory dermatologic diseases, including atopic dermatitis and psoriasis. In addition, recent studies have shown that obesity impairs lymphatic function. As the lymphatic system is a critical regulator of inflammatory reactions, w...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Pau Castel; Pedram Razavi;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Unraveling resistance to ... (1R01CA190642-01A1), RCUK | Understanding signalling ... (MC_UU_12016/2)

    Castel et al. show that PDK1 activates SGK1 to phosphorylate and inhibit TSC2, contributing to maintenance of mTORC1 activity and resistance of PIK3CA-mutant cancer cells to PI3Kα inhibition. Targeting either PDK1 or SGK1 restores the sensitivity of these resistant canc...

  • publication . Article . 2016
    Open Access English
    Authors:
    Andrew W Bergen; Themistocles Assimes;
    Publisher: Elsevier
    Project: NIH | Inflammation Genes and Lu... (1R01CA127219-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | COORDINATING CENTER FOR W... (N01WH022110-014), NIH | ECOGENETICS OF LUNG CANCE... (1R01CA055769-01), NIH | GENETIC EPIDEMIOLOGY OF L... (7R01CA060691-03), NIH | Genetic and Molecular Epi... (5R01CA052689-13), NIH | Genetic Susceptibility fo... (1R01CA141716-01), NIH | Administrative Core (5U19CA148127-02), NIH | BIOMARKERS OF LUNG CANCER... (1R01ES006717-01A1)

    Highlights • Genetic by environment (e.g., cigarettes/day, CPD) interactions for lung cancer are understudied in non-European ancestry populations. • We analyzed interactions between nominal smoking quantity SNPs (n = 7156 discovery sample) and CPD and risk of lung canc...

  • publication . Article . Other literature type . 2012
    Open Access
    Authors:
    Prasad Devarajan; David A. Solá-Del Valle; Kiyoshi Mori; Catherine S. Forster;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    The rate of progression of chronic kidney disease (CKD) is difficult to predict using single measurements of serum creatinine or proteinuria. On the other hand, documented tubulointerstitial disease presages worsening CKD, but kidney biopsy is not practical for routine ...

12 research outcomes, page 1 of 2
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