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14 research outcomes, page 1 of 2
  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Liselle Guiang; Lei Shi; Alexis Dziedziech; Wenhu Zhan; Pradeep K Singh;
    Publisher: National Academy of Sciences
    Project: NIH | Species selective dipepti... (5R21AI101393-02), NIH | Identification of the tar... (1R21AI094167-01A1), NIH | Resistance of Malaria Par... (5R01AI075045-07), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Novel Inhibitors of Malar... (1R21AI123794-01A1), NSF | cGMP signalling in Plasmo... (1146221)

    Significance Protozoal proteasome is a validated target for antimalarial drug development, but species selectivity of reported inhibitors is suboptimal. Here we identify inhibitors with improved selectivity for malaria proteasome β5 subunit over each active subunit of h...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Cristina Bernadó Morales; Carles Monterrubio; Timothy L. Lochmann; Violeta Serra; Mikhail Dozmorov; Ming Tan; Joaquin Arribas; Konstantinos Floros; Jennifer Koblinski;
    Publisher: Proceedings of the National Academy of Sciences
    Project: NIH | Assessing BIM expression ... (1K22CA175276-01), NIH | CORE--PLANNING AND EVALUA... (5P30CA016059-20), NIH | MOUSE GENETICS (2P30CA008748-43)

    Significance In HER2-amplified breast cancers, HER2 inhibitors have been very successful as adjuvant therapy but not as monotherapy. Here, we demonstrate that coamplification of a HER2 intronic miRNA causes intrinsic resistance to HER2 inhibitors by indirectly down-regu...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Maxime Deforet; Leila Akkari;
    Publisher: HAL CCSD
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | The CSBC Research Center ... (3U54CA209975-01S1), NIH | Using extracellular metab... (4R00CA191021-03)

    <jats:p>The genetic and phenotypic diversity of cells within tumors is a major obstacle for cancer treatment. Because of the stochastic nature of genetic alterations, this intratumoral heterogeneity is often viewed as chaotic. Here we show that the altered metabolism of...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Mark Rubin; Dr. Judith Balmaña; Pasquale Rescigno; Joaquin Mateo;
    Publisher: National Academy of Sciences NAS
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Clinical Development of T... (5P50CA097186-13), EC | SPICE (648670), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10), NIH | SPORE in Prostate Cancer (5P50CA090381-05), NIH | Towards Understanding Pro... (5R01CA125612-04), NIH | A Precision Medicine Appr... (5P50CA186786-02)

    Heterogeneity in the genomic landscape of metastatic prostate cancer has become apparent through several comprehensive profiling efforts, but little is known about the impact of this heterogeneity on clinical outcome. Here, we report comprehensive genomic and transcript...

  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Hisham Bazzi;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), WT

    Regulated mesoderm migration is necessary for the proper morphogenesis and organ formation during embryonic development. Cell migration and its dependence on the cytoskeleton and signaling machines have been studied extensively in cultured cells; in contrast, remarkably...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Christopher Lima; Shaun Olsen; Michaelyn C. Lux; Zachary Hann;
    Publisher: Proceedings of the National Academy of Sciences
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Rational Design of Adenyl... (5R01GM100477-08), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Structural studies of RNA... (1R35GM118080-01), NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), NIH | Structural and Functional... (5R01GM079196-07), NIH | Structural Studies of SUM... (5R01GM065872-12)

    Significance Posttranslational protein modification by ubiquitin (Ub) regulates aspects of biology, including protein turnover and the cell cycle. Proteins and enzymes that promote Ub conjugation are therapeutic targets because they are sometimes dysregulated in cancer,...

  • publication . Other literature type . Preprint . Article . 2018
    Open Access
    Authors:
    Paul Greengard; George Liao; Peng Xu;
    Publisher: Proceedings of the National Academy of Sciences
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Predoctoral Training in P... (1T32GM073546-01A1), NIH | MECHANISMS FOR SELECTIVE ... (1R01AG047781-01), NIH | Substrate Feedback Mechan... (1RF1AG057593-01), NIH | Mechanism and Synergy of ... (5R01NS096275-03)

    Significance γ-Secretase cleaves multiple transmembrane proteins, but little is known about how it controls its substrate specificity. γ-Secretase activating protein (GSAP) has been reported to differentially activate γ-secretase for APP and Notch cleavages. The mechani...

  • publication . Article . 2018
    Open Access English
    Authors:
    Pujuan Deng; Yuqiao Zhou; Junyi Jiang; Haojie Li; Wei Tian; Yinghua Cao; Yan Qin; Jaehoon Kim; Robert G. Roeder; Dinshaw J. Patel; ...
    Publisher: National Academy of Sciences
    Project: NIH | Mechanisms of p53 target ... (5R01CA129325-03), NIH | Nuclear Receptor Coactiva... (5R01DK071900-04), NIH | MOUSE GENETICS (2P30CA008748-43)

    Significance The polymerase-associated factor 1 (PAF1) complex is a general transcription elongation factor of RNA polymerase II, which not only regulates various stages of the transcription cycle but also broadly influences gene expression through modulating chromatin ...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Sanford Simon; David Requena;
    Publisher: Proceedings of the National Academy of Sciences
    Project: NIH | Cellular Pathogenesis of ... (5R56CA207929-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Intratumoral Heterogeneit... (5F31CA192835-03)

    <jats:p>A segmental deletion resulting in <jats:italic>DNAJB1–PRKACA</jats:italic> gene fusion is now recognized as the signature genetic event of fibrolamellar hepatocellular carcinoma (FL-HCC), a rare but lethal liver cancer that primarily affects adolescents and youn...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Paul B. Romesser; Amanda S. Kim; Jeho Jeong; Allison Mayle; Lukas E. Dow; Scott W. Lowe;
    Publisher: Proceedings of the National Academy of Sciences
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | A scalable platform for t... (1R01CA195787-01), NIH | MSK Paul Calabresi Career... (5K12CA184746-02), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04)

    Significance Currently, there are no therapies available to mitigate intestinal damage after radiation injury. Efforts to study and design new therapies are hampered by a lack of models that can be readily adopted to study therapeutic targets. Here we describe a preclin...

14 research outcomes, page 1 of 2
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