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24 research outcomes, page 1 of 3
  • publication . Article . 2008
    Open Access
    Authors:
    David Shechter; Paul Tempst; Haitao Li;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    DNA double-stranded breaks present a serious challenge for eukaryotic cells. The inability to repair breaks leads to genomic instability, carcinogenesis and cell death. During the double-strand break response, mammalian chromatin undergoes reorganization demarcated by H...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Jianjiong Gao;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | The cBioPortal for Cancer... (1U24CA220457-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Clinical Scholars Biomedi... (2T32CA009512-29A1), NIH | Exploring second-tier pos... (1F32GM123659-01), NIH | Core 3: Quantitative Prot... (1P01CA196539-01)

    Mutations in epigenetic pathways are common oncogenic drivers. Histones, the fundamental substrates for chromatin-modifying and remodelling enzymes, are mutated in tumours including gliomas, sarcomas, head and neck cancers, and carcinosarcomas. Classical ‘oncohistone’ m...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Bruno Costa-Silva; Tang-Long Shen; Angela Di Giannatale; Sophia Ceder; Hector Peinado; Rajasekhar Vinagolu;
    Publisher: eScholarship, University of California
    Project: NIH | Characterization and Func... (1U01CA169538-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Exosome-mediated Transfer... (5R01CA169416-03)

    © 2015 Macmillan Publishers Limited. All rights reserved. Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour c...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Steven Albanese; Andrew Intlekofer; John Chodera;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Role of IDH Mutations in ... (1R01CA168802-01A1), NIH | Synergistic role of signa... (1R35CA197594-01A1), NIH | Investigating L-2-hydroxy... (5K08CA201483-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Analysis of TET2 function... (5K08CA181507-03), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04)

    Somatic mutations in the isocitrate dehydrogenase 2 gene (IDH2) contribute to the pathogenesis of acute myeloid leukaemia (AML) through the production of the oncometabolite 2-hydroxyglutarate (2HG)1–8. Enasidenib (AG-221) is an allosteric inhibitor that binds to the IDH...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Robert Liefke;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Histone demethylases and ... (5R01CA118487-10), NIH | High-Resolution Analysis ... (5R01HG003985-09)

    The Polycomb repressive complex 2 (PRC2) mainly mediates transcriptional repression and has essential roles in various biological processes including the maintenance of cell identity and proper differentiation. Polycomb-like (PCL) proteins, such as PHF1, MTF2 and PHF19,...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Stanislav Dikiy; Rachel Niec;
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Self Peptides Bound to MH... (5R37AI034206-18)

    Adaptive immune responses are tailored to different types of pathogens through differentiation of naive CD4 T cells into functionally distinct subsets of effector T cells (T helper 1 (TH1), TH2, and TH17) defined by expression of the key transcription factors T-bet, GAT...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Shohei Koide; Stephen Long;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOLECULAR GENETIC ANALYSI... (5F32GM012006-03), NIH | Bridge 1: Conformational ... (2U54GM087519-06), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14)

    The X-ray structure of the integral membrane protein isoprenylcysteine carboxyl methyltransferase suggests mechanisms by which it recognizes both water-soluble and membrane-bound reactants to catalyze the methylation of RAS and other CAAX proteins at the membrane-cytoso...

  • publication . Other literature type . Article . 2014
    Open Access
    Authors:
    Andrea Ventura; Danilo Maddalo; Joana A. Vidigal;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    The CRISPR/Cas system has been used to induce the Eml4–Alk chromosomal inversion in mice, a characteristic chromosomal rearrangement seen in human non-small cell lung cancers; the mice developed lung cancer and responded to the ALK inhibitor crizotinib, which is used to...

  • publication . Article . Other literature type . 2008
    Open Access
    Authors:
    xiangting wang; Paul Tempst;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | TRANSCRIPTIONAL COREGULAT... (5R01CA052599-12), NIH | INTEGRATION OF TRANSCRIPT... (5R01HL059694-05)

    DNA damage induces expression of a non-coding RNA, which acts like a ligand to recruit a specific RNA-binding protein, TLS. This protein in turn represses transcription of the gene to which the non-coding RNA is tethered by inhibiting a histone acetyltransferase coactiv...

  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Masanori Okaniwa; ZHAN YAO;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of Metastasis ... (5P01CA094060-07), NIH | Orexin/Hypocretin Recepto... (7P50AA017072-07)

    Inhibitors of the mTOR kinase are in clinical trials for the treatment of cancer; here, mutations in mTOR that can lead to drug resistance are investigated and the results are used to design a new class of mTOR inhibitors that can overcome this resistance. Inhibitors of...

24 research outcomes, page 1 of 3
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