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14 research outcomes, page 1 of 2
  • publication . Article . Other literature type . 1998
    Open Access English
    Authors:
    Alpha Yap;
    Publisher: The Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Biochemistry and Regulati... (5R01GM052717-16)

    <jats:p>Cadherin cell–cell adhesion molecules form membrane-spanning molecular complexes that couple homophilic binding by the cadherin ectodomain to the actin cytoskeleton. A fundamental issue in cadherin biology is how this complex converts the weak intrinsic binding ...

  • publication . Other literature type . Article . 1999
    Open Access
    Authors:
    William Brieher;
    Publisher: Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Biochemistry and Regulati... (5R01GM052717-16)

    <jats:p>The regulation of cadherin-mediated adhesion at the cell surface underlies several morphogenetic processes. To investigate the role of cadherin regulation in morphogenesis and to begin to analyze the molecular mechanisms of cadherin regulation, we have screened ...

  • publication . Other literature type . Article . 2005
    Open Access
    Authors:
    Tomoyo Okada; Miguel Lopez-Lago; Filippo G. Giancotti;
    Publisher: Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Role of the Adaptor Prote... (2R01CA078901-06)

    <jats:p>Introduction of activated p21-activated kinase (PAK) is sufficient to release primary endothelial cells from contact inhibition of growth. Confluent cells display deficient activation of PAK and translocation of Rac to the plasma membrane at matrix adhesions. Ta...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Scott Keeney; MEHMET ERMAN KARASU; Katja Wassmann;
    Publisher: Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Cyclins control the switch-like cell cycle transitions that orchestrate orderly duplication and segregation of genomes. Karasu et al. delineate an essential function for mouse cyclin B3 for anaphase onset in the first meiotic division of oocytes.

  • publication . Other literature type . Article . 2008
    Open Access
    Authors:
    Aron Jaffe;
    Publisher: Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Rho GTPases and polarity ... (5R01GM081435-06)

    <jats:p>The establishment of apical–basal polarity within a single cell and throughout a growing tissue is a key feature of epithelial morphogenesis. To examine the underlying mechanisms, the human intestinal epithelial cell line Caco-2 was grown in a three-dimensional ...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Aaron Viny; Barbara Spitzer; Martin A. Rivas; Cem Meydan;
    Publisher: Rockefeller University Press
    Project: NIH | Chemical Modulation of Ch... (1K99CA190861-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Clinical Scholars Biomedi... (5T32CA009512-27)

    Viny et al. show that depletion of the cohesin subunit Smc3 affects HSC function through disruption of chromatin structure and that cohesin haploinsufficiency cooperates with Flt3-ITD to induce transformation of stem/progenitor cells and leukemia development.

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Juan Manuel Schvartzman; Craig B. Thompson; Lydia W.S. Finley;
    Publisher: Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Dynamic regulation of gene expression in response to changing local conditions is critical for the survival of all organisms. In metazoans, coherent regulation of gene expression programs underlies the development of functionally distinct cell lineages. The cooperation ...

  • publication . Article . 1997
    Open Access English
    Authors:
    Hediye Erdjument-Bromage;
    Publisher: The Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NSF | Automated Instrument for ... (9420123)

    <jats:p>We report the identification and characterization of ERS-24 (Endoplasmic Reticulum SNARE of 24 kD), a new mammalian v-SNARE implicated in vesicular transport between the ER and the Golgi. ERS24 is incorporated into 20S docking and fusion particles and disassembl...

  • publication . Article . 2017
    Open Access English
    Authors:
    Joshua Kavaler; Hong Duan; Rajaguru Aradhya; Luis F. de Navas; Brian Joseph; Boris Shklyar; Eric C. Lai;
    Publisher: The Rockefeller University Press
    Project: NIH | BEN factors are conserved... (5R01NS074037-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanism and regulation ... (2R01NS083833-06), NIH | Non-canonical miRNA bioge... (2R01GM083300-06)

    Large-scale knockout studies suggest that most miRNAs are phenotypically dispensable. However, Kavaler et al. show here that developmental specification toward a non-neuronal fate in the Drosophila melanogaster peripheral sensory organ lineage depends critically on mir-...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Jonathan N. Rosen; Mafalda Azevedo; David B. Soffar; Vitaly P. Boyko; Matthew B. Brendel; Victoria K. Schulman; Mary K. Baylies;
    Publisher: Rockefeller University Press
    Project: NIH | Drosophila Genomics Resou... (2P40OD010949-10A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms Regulating Myo... (3R01GM078318-03S1)

    Rosen et al. identify a role for the centrosomal protein Bsg25D/Ninein in nuclear positioning and microtubule organization in Drosophila muscle fibers. Genetic, cell biological, and atomic force microscopy analyses demonstrate that complex interactions between Bsg25D an...

14 research outcomes, page 1 of 2
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