Download Results
3 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Andrew R. Griswold; Daniel P. Ball; Abir Bhattacharjee; Ashley J. Chui; Sahana D. Rao; Cornelius Y. Taabazuing; Daniel A. Bachovchin;
    Publisher: American Chemical Society
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Characterizing the Mechan... (1R01AI137168-01)

    Inflammasomes are multiprotein complexes formed in response to pathogens. NLRP1 and CARD8 are related proteins that form inflammasomes, but the pathogen-associated signal(s) and the molecular mechanisms controlling their activation have not been established. Inhibitors ...

  • publication . Other literature type . Article . 2014
    Open Access
    Authors:
    Kendra K. Harris; Allison Fay; Han-Guang Yan; Pratima Kunwar; Nicholas D. Socci; Narender Pottabathini; Ramakrishna R. Juventhala; Hakim Djaballah; Michael S. Glickman;
    Publisher: American Chemical Society (ACS)
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | Vanderbilt-Emory-Cornell-... (5R25TW009337-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Immunology Research Train... (5T32CA009149-28)

    Bacterial antimicrobial resistance is an escalating public health threat, yet the current antimicrobial pipeline remains alarmingly depleted, making the development of new antimicrobials an urgent need. Here, we identify a novel, potent, imidazoline antimicrobial compou...

  • publication . Article . 2014
    Open Access English
    Authors:
    Gil Blum; Glorymar Ibáñez; Xiangjun Rao; David Shum; Constantin Radu; Hakim Djaballah; Judd C. Rice; Minkui Luo;
    Publisher: American Chemical Society
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Enzyme-engineering Approa... (1DP2OD007335-01), NIH | Molecular mechanisms of g... (1R01GM075094-01A2), NIH | Developing High Throughpu... (1R21NS071520-01A1), NIH | Profile substrates and in... (1R01GM096056-01)

    SETD8/SET8/Pr-SET7/KMT5A is the sole protein lysine methyltransferase (PKMT) known to monomethylate lysine 20 of histone H4 in vivo. SETD8’s methyltransferase activity has been implicated in many essential cellular processes including DNA replication, DNA damage respons...

3 research outcomes, page 1 of 1
Last index information