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25 research outcomes, page 1 of 3
  • publication . Article . 2011
    Open Access English
    Authors:
    Yacine M. Amrani; Jonathan Gill; Armine Matevossian; Eric S. Alonzo; Chingwen Yang; Jae-Hung Shieh; Malcolm A. Moore; Christopher Y. Park; Derek B. Sant'Angelo; Lisa K. Denzin;
    Publisher: The Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Translational linkage str... (5F31CA130744-03)

    Hematopoietic stem cells (HSCs) self-renew to maintain the lifelong production of all blood populations. Here, we show that the proliferating cell nuclear antigen–associated factor (Paf) is highly expressed in cycling bone marrow HSCs and plays a critical role in hemato...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Green, Jesse A.; Arpaia, Nicholas; Schizas, Michail; Dobrin, Anton; Rudensky, Alexander Y.;
    Publisher: The Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Self Peptides Bound to MH... (5R37AI034206-18)

    The involvement of effector T cells and regulatory T (T reg) cells in opposing and promoting solid organ carcinogenesis, respectively, is viewed as a shifting balance between a breach versus establishment of tolerance to tumor or self-antigens. We considered that tumor-...

  • publication . Other literature type . Article . 2001
    Open Access
    Authors:
    Antonio Di Cristofano;
    Publisher: Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | SEARCH FOR EXPLOITABLE DI... (1P01CA064593-04)

    <jats:p>p62dok has been identified as a substrate of many oncogenic tyrosine kinases such as the chronic myelogenous leukemia (CML) chimeric p210bcr-abl oncoprotein. It is also phosphorylated upon activation of many receptors and cytoplamic tyrosine kinases. However, th...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Bharat Vaidyanathan; Ashutosh Chaudhry; William T. Yewdell; Davide Angeletti; Wei-Feng Yen; Adam K. Wheatley; Christopher A. Bradfield; Adrian B. McDermott; Jonathan W. Yewdell; Alexander Y. Rudensky; ...
    Publisher: Rockefeller University Press
    Project: NIH | ELUCIDATION OF IMMUNOGLOB... (5R01AI072194-04), NIH | Characterization of the A... (5R37ES005703-20), NIH | RNA-directed targeting of... (5R01AI124186-02), NIH | MOUSE GENETICS (2P30CA008748-43)

    Generation of cellular heterogeneity is an essential feature of the adaptive immune system. This is best exemplified during humoral immune response when an expanding B cell clone assumes multiple cell fates, including class-switched B cells, antibody-secreting plasma ce...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Matthew T. Sorbara; Krista Dubin; Eric R. Littmann; Thomas U. Moody; Emily Fontana; Ruth Seok; Ingrid M. Leiner; Ying Taur; Jonathan U. Peled; Marcel R.M. van den Brink; ...
    Publisher: Rockefeller University Press
    Project: NIH | Innate Immune Defense aga... (5R01AI095706-03), NIH | Systems Biology of Microb... (5U01AI124275-03), NIH | TNF Mediated Immune Defen... (5R01AI042135-09), NIH | MOUSE GENETICS (2P30CA008748-43), CIHR

    Klebsiella pneumoniae, Escherichia coli, and other members of the Enterobacteriaceae family are common human pathogens that have acquired broad antibiotic resistance, rendering infection by some strains virtually untreatable. Enterobacteriaceae are intestinal residents,...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Xiying Fan; Bruno Moltedo; Alejandra Mendoza; Alexey N. Davydov; Mehlika B. Faire; Linas Mazutis; Roshan Sharma; Dana Pe’er; Dmitriy M. Chudakov; Alexander Y. Rudensky;
    Publisher: Rockefeller University Press
    Project: NIH | Self Peptides Bound to MH... (5R37AI034206-18), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Function of Regulatory T ... (5F30AI122721-02)

    Fan et al. have identified a population of recirculating Treg cells with greater suppressive ability and a unique tissue distribution. Using single-cell RNA-seq, they place these Treg cells at the apex of the Treg developmental trajectory and show that similar cells may...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Kamini Singh; Jianan Lin; Yi Zhong; Antonija Burčul; Prathibha Mohan; Man Jiang; Liping Sun; Vladimir Yong-Gonzalez; Agnes Viale; Justin R. Cross; ...
    Publisher: Rockefeller University Press
    Project: NIH | The genomic pathogenesis ... (5R01CA190384-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Towards The Chemotherapy-... (1R01CA183876-01), NIH | RNA Structurome in Post-T... (5R35GM124998-02), NIH | Exploring oncogenic trans... (5R01CA207217-03)

    Singh et al. show that MYC affects mRNA translation efficiency and start-site selection. Notable examples include the translation of mRNAs encoding most proteins of the electron transport chain and aberrant translation initiation site usage in the CD19 receptor that all...

  • publication . Other literature type . Article . 2006
    Open Access
    Authors:
    Hediye Erdjument-Bromage; Paul Tempst;
    Publisher: Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Role of PKCDelta in B cel... (5R01AI050867-02)

    <jats:p>B cell life depends critically on the cytokine B cell–activating factor of the tumor necrosis factor family (BAFF). Lack of BAFF signaling leads to B cell death and immunodeficiency. Excessive BAFF signaling promotes lupus-like autoimmunity. Despite the great im...

  • publication . Article . 2017
    Open Access English
    Authors:
    Charalambos Kaittanis; Chrysafis Andreou; Haley Hieronymus; Ninghui Mao; Catherine A. Foss; Matthias Eiber; Gregor Weirich; Palak Panchal; Anuradha Gopalan; Juan Zurita; ...
    Publisher: The Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | PEG-like Multimodal Nanop... (5R01EB017699-03), NIH | Exploring PSMA Biology in... (1R01CA212379-01A1), NIH | The Ivis Spectrum CT for ... (1S10OD016207-01)

    Kaittanis et al. show that the processing of glutamated folates by prostate-specific membrane antigen induces the activation of metabotropic glutamate receptors and initiation of PI3K–Akt signaling in prostate cancer.

  • publication . Article . 1998
    Open Access
    Authors:
    Hamada, Tsuneyoshi; Möhle, Robert; Hesselgesser, Joseph; Hoxie, James; Nachman, Ralph L.; Moore, Malcolm A.S.; Rafii, Shahin;
    Publisher: Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | CHEMOKINE RECEPTORS AND I... (5R01HL061849-03), NIH | ENDOTHELIUM REGULATION OF... (5R01HL058707-04)

    <jats:p>Although thrombopoietin has been shown to promote megakaryocyte (MK) proliferation and maturation, the exact mechanism and site of platelet formation are not well defined. Studies have shown that MKs may transmigrate through bone marrow endothelial cells (BMEC),...

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