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2 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Jason Lewis; Nerissa Viola; Linden Wyatt; Mirkka P Sarparanta;
    Publisher: American Chemical Society (ACS)
    Project: NIH | pHLIP-based agents for pr... (1F32CA186721-01A1), NIH | Shared Instrument: Focus ... (1S10RR020892-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | PET Imaging of Cancer wit... (5R01CA138468-04), NIH | The Ivis Spectrum CT for ... (1S10OD016207-01), AKA | New radiolabeled molecula... (278056)

    pH (low) insertion peptides (pHLIP peptides) target acidic extracellular environments in vivo due to pH-dependent cellular membrane insertion. Two variants (Var3 and Var7) and wild-type (WT) pHLIP peptides have shown promise for in vivo imaging of breast cancer. Two pos...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Naga Vara Kishore Pillarsetty; Jason Lewis;
    Publisher: American Chemical Society (ACS)
    Project: NIH | Characterization of human... (2R42CA128362-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Bioorthogonal Strategies ... (1K25EB016673-01), NIH | Molecular Imaging: Traini... (1R25CA096945-01), NIH | Pretargeted Radioimmunoth... (4R00CA178205-02), NIH | Developing an Anti-sialyl... (5F32CA180452-03)

    A first-of-its-kind 18F pretargeted PET imaging approach based on the bioorthogonal inverse electron demand Diels–Alder (IEDDA) reaction between tetrazine (Tz) and trans-cyclooctene (TCO) is presented. As proof-of-principle, a TCO-bearing immunoconjugate of the anti-CA1...

2 research outcomes, page 1 of 1
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